Roles of Mitochondrial DNA in Energy Metabolism

Lv, Jiapei; Bhatia, Madhav; Wang, Xiangdong

doi:10.1007/978-981-10-6674-0_6

Cited by 12 publications

(7 citation statements)

References 60 publications

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“…The main pathogenesis of vascular dementia (VD) includes chronic cerebral hypoperfusion ( Damodaran et al, 2019 ), synaptic disorders ( Sun, 2018 ), axonal abnormalities ( Kalaria, 2018 ), hippocampal neuron loss ( Jiang et al, 2019 ), and white matter vascular changes ( Hase et al, 2019 ), which ultimately lead to cognitive impairment and dementia. The mitochondria are the main organelles involved in ischemia ( Lv et al, 2017 ). Mitochondrial dysfunction in the brain plays an important role in the pathogenesis of VD.…”

Section: Discussionmentioning

confidence: 99%

Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review

Tuo

Yan²,

Linghu³

et al. 2023

Front. Pharmacol.

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Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022. Fourteen studies that followed the inclusion criteria were integrated, analyzed, and summarized. Several studies have shown that natural products can improve or reduce cognitive dysfunction by ameliorating mitochondrial dysfunction. These results suggest that natural products may serve as new therapeutic targets for neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review

Tuo

Yan²,

Linghu³

et al. 2023

Front. Pharmacol.

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“…Nuclear respiratory factor-1 (NRF-1) is a nuclear transcription factor that stimulates expression of nuclear genes to enhance mitochondrial respiratory function. Mitochondrial transcription factor A (TFAM), a DNA-binding protein, controls mitochondrial metabolism and dysfunction by regulating the transcription of its genome and organizing mitochondrial DNA (mtDNA) (18). PGC-1α activates TFAM by serving as a co-transcription factor of NRF-1, thereby regulating mitochondrial biogenesis (19).…”

Section: Mitochondrial Dynamics and Biogenesis Indicators May Serve A...mentioning

confidence: 99%

Mitochondrial dynamics and biogenesis indicators may serve as potential biomarkers for diagnosis of myasthenia gravis

Cai

Huiya

et al. 2022

Exp Ther Med

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Due to challenges in diagnosing myasthenia gravis (MG), identifying novel diagnostic biomarkers for this disease is essential. Mitochondria are key organelles that regulate multiple physiological functions, such as energy production, cell proliferation and cell death. In the present study, Mfn1/2, Opa1, Drp1, Fis1, AMPK, PGC-1α, NRF-1 and TFAM were compared between patients with MG and healthy subjects to identify potential diagnostic biomarkers for MG. Blood samples were collected from 50 patients with MG and 50 healthy subjects. The participants' demographic information and routine blood test results were recorded. Mitochondrial dynamics were evaluated and levels of Mfn1/2, Opa1, Drp1, Fis1, AMPK, PGC-1α, NRF-1 and TFAM were determined in peripheral blood mononuclear cells using western blotting and reverse transcription-quantitative PCR, respectively. Receiver operating characteristic curve analysis was used to evaluate the diagnostic accuracy of these indicators. The areas under the curve values of Mfn1/2, Opa1, Drp1, Fis1,AMPK, PGC-1α, NRF-1 and TFAM were 0.5408-0.8696. Compared with control subjects, mRNA expression levels of Mfn1/2, Opa1, AMPK, PGC-1α, NRF-1 and TFAM were lower, while those of Drp1 and Fis1 were higher in patients with MG. The protein expression levels of all these molecules were lower in patients with MG than in control subjects. These results suggested that mitochondrial dynamics and biogenesis indicators may be diagnostic biomarkers for MG.

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“…Mitochondria can be an important control driver in the production of cell energy regulated by the MtDNA. MtDNA acts as the command control center to schedule energetic productions and maintain cell metabolisms and molecular diversification within the mitochondria, responsible for the development of diseases (Sun et al 2017;Lv et al 2017). It is clear that the mitochondria function as the energy motor and control a series of organelle responses and signal pathways in CBT, while a large number of intracellular or extracellular elements can influence, regulate, or control the mitochondrial function.…”

Section: Thinking Of Mitochondrial Dnamentioning

confidence: 99%

The role of mitochondria in cellular toxicity as a potential drug target

Wang

Sun

2018

Cell Biol Toxicol

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Mitochondrial malfunction is related to aging and to the onset of many diseases, such as obesity/diabetes, cancer, and cardiovascular and neurodegenerative diseases. The molecular principles of biological and toxicological processes the mitochondria can regulate should be disease-specific, cell type-specific, and drug targetable. Mitochondrial biology and toxicology is evolving and undergoing a revolution through fast-developing biotechnologies garnering increasing attention due to the importance of targeted therapies. Mitochondrial energy production and metabolism are conducted via post-mitochondrial signaling, and are controlled by extra-mitochondrial pathways. Mitochondrial biology and toxicology has a history spanning over 30 years and is one of the main scientific focuses at Cell Biology and Toxicology. It is our aim to pioneer innovations of mitochondrial biology and toxicology to improve the understanding, highlight the latest development, and find mitochondria-based targets for therapies. It is expected to know how drugs can initiate mitochondrial dysfunction, the role of nuclear messages in regulating mitochondrial DNA (MtDNA), and how mitochondria communicate between or with other cells. Further studies are crucial to discover how mitochondria control the process of immune response, autophagy/mitophagy, genome activation, and cell interaction. It is also needed to innovate how the transcription is started and terminated within mitochondria, the cytosolic proteins and other organelles interact with mitochondria, and MtDNA regulates the function of mitochondrial respiratory megacomplexes.

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Roles of Mitochondrial DNA in Energy Metabolism

Cited by 12 publications

References 60 publications

Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review

Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review

Mitochondrial dynamics and biogenesis indicators may serve as potential biomarkers for diagnosis of myasthenia gravis

The role of mitochondria in cellular toxicity as a potential drug target

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