Roles of long noncoding RNAs in aging and aging complications

Jin, Ling; Song, Qirui; Zhang, Weili; Geng, Bin; Cai, Jun

doi:10.1016/j.bbadis.2018.09.021

Cited by 26 publications

(18 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Upon ageing, no specific changes in isoform expression could be observed at this resolution but the long-read data did show increased expression of lncRNAs. Highly tissue-specific changes in lncRNAs expression in aged human tissues has been reported 33 and abnormally elevated expression of some lncRNAs seem to relate to telomere shortening and senescence 34 . Similarly, an overall increase in intron retention was observed.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells

Mincarelli

Uzun

Wright

et al. 2021

Preprint

View full text Add to dashboard Cite

Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed progenitor, marked by changes in gene expression. However, many of these approaches neglect isoform level information, and thus do not capture the extent and effect of alternative splicing within the system. Here, we present the first integrated short- and long-read single-cell RNA-seq of haematopoietic stem and progenitor cells. We demonstrate that over half of genes detected in standard short-read single-cell analyses are expressed as multiple, often functionally distinct, isoforms. This includes many transcription factors and key cytokine receptors, and in particular the Thrombopoietin receptor Mpl, which displays complex isoform expression patterns between individual hematopoietic stem cells. The dataset further reveals novel signatures of hematopoietic ageing, including a global increase in lncRNA expression. Strikingly, the long-read sequencing enables us to observe aberrant expression of full-length VJ-rearranged immunoglobulin kappa transcripts in aged haematopoietic stem cells, prior to lymphoid commitment. Integrating single cell and cell-type specific isoform landscape in normal and aged hematopoiesis provides a new reference for accurate molecular profiling of heterogeneous tissues, as well as novel insights into transcriptional complexity, cell-type specific splicing events and effects of ageing.

show abstract

Section: Discussionmentioning

confidence: 99%

Comprehensive single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells

Mincarelli

Uzun

Wright

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The third main element of epigenetic regulation, non-coding RNAs, with broad two categories, short non-coding RNAs (sncRNA) and long non-coding RNAs (lncRNAs), is reported to display some disrupted functions with aging [74][75][76][77]. Mainly, micro RNAs (miRNA) and lncRNAs were studied for their age-related aspects and, in fact, the majority of miRNAs were shown to be downregulated with age [78][79][80].…”

Section: Epigenetic Mechanisms In Cancer Transformation and Agingmentioning

confidence: 99%

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

et al. 2020

View full text Add to dashboard Cite

The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer. In this review, we present problems associated with the diet and nutrition in the elderly undergoing active cancer therapy and provide some information on epigenetic aspects of aging and cancer transformation. Nutritional interventions modulating the epigenetic profile, including caloric restriction and basal diet with modifications (elimination diet, supplementary diet) are discussed as the ways to improve the efficacy of cancer therapy and maintain the quality of life of older adults with cancer.

show abstract

“…For the examination of neurodegenerative diseases in clinical settings, lncRNAs hold great potential since brain lncRNAs can be detected in peripheral fluids [ 213 ] and can thus be explored as biomarkers for both following disease progression and evaluating the outcome of therapeutic regimes. It is also possible that the study of the regenerative potential of the peripheral nervous system, where several lncRNAs are expressed during the regenerative period that follows injury [ 214 ], will provide new targets that could be leveraged for driving the repair of the damaged central nervous system or possibly to revert some of the changes observed in aging [ 215 ].…”

Section: Discussionmentioning

confidence: 99%

Brain Long Noncoding RNAs: Multitask Regulators of Neuronal Differentiation and Function

2021

View full text Add to dashboard Cite

The extraordinary cellular diversity and the complex connections established within different cells types render the nervous system of vertebrates one of the most sophisticated tissues found in living organisms. Such complexity is ensured by numerous regulatory mechanisms that provide tight spatiotemporal control, robustness and reliability. While the unusual abundance of long noncoding RNAs (lncRNAs) in nervous tissues was traditionally puzzling, it is becoming clear that these molecules have genuine regulatory functions in the brain and they are essential for neuronal physiology. The canonical view of RNA as predominantly a ‘coding molecule’ has been largely surpassed, together with the conception that lncRNAs only represent ‘waste material’ produced by cells as a side effect of pervasive transcription. Here we review a growing body of evidence showing that lncRNAs play key roles in several regulatory mechanisms of neurons and other brain cells. In particular, neuronal lncRNAs are crucial for orchestrating neurogenesis, for tuning neuronal differentiation and for the exact calibration of neuronal excitability. Moreover, their diversity and the association to neurodegenerative diseases render them particularly interesting as putative biomarkers for brain disease. Overall, we foresee that in the future a more systematic scrutiny of lncRNA functions will be instrumental for an exhaustive understanding of neuronal pathophysiology.

show abstract

Roles of long noncoding RNAs in aging and aging complications

Cited by 26 publications

References 91 publications

Comprehensive single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells

Comprehensive single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

Brain Long Noncoding RNAs: Multitask Regulators of Neuronal Differentiation and Function

Contact Info

Product

Resources

About