Roles of lithogenic bile and cystic duct occlusion in the pathogenesis of acute cholecystitis

Roslyn, Joel J.; DenBesten, Lawrence; Thompson, Jesse E.; Silverman, Barry F.

doi:10.1016/0002-9610(80)90428-6

Cited by 69 publications

(43 citation statements)

References 13 publications

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“…The advantage of CBDL over other models of acute inflammation of the gallbladder, such as cystic duct ligation [18], is that there is no chemical or physical manipulation of the gallbladder which may cause artifactual results [4]. As shown in this and our previous study [5], CBDL in the guinea pig causes acute inflammation which increases progressively in severity from days 1 to 3 postligation.…”

Section: Discussionmentioning

confidence: 74%

Effect of Acalculous Cholecystitis on Gallbladder Neuromuscular Transmission and Contractility

Parkman

James

Bogar

et al. 2000

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 74%

Effect of Acalculous Cholecystitis on Gallbladder Neuromuscular Transmission and Contractility

Parkman

James

Bogar

et al. 2000

Journal of Surgical Research

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“…On the other hand, small CBD stones in association with a non-dilated CBD are more likely to originate from the GB. If cholecystectomy is not performed in such patients, acute cholecystitis development due to cystic duct obstruction by a gallstone is a risk during the process of passage [37,38] . The same assumption can be applied to patients with a low total bilirubin level who were found to develop acute cholecystitis more frequently.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of acute cholecystitis after endoscopic common bile duct stone removal

Ryu¹,

Park

Yoon³

et al. 2006

WJG

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have a higher risk of acute cholecystitis and are possible candidates for prophylactic cholecystectomy. INTRODUCTIONEndoscopic sphincterotomy is the treatment of choice for patients with common bile duct (CBD) stones. The high success rate and safety of this modality have been well established by a number of studies [1][2][3][4][5] . Because gallstones may pass from the gallbladder (GB) into the CBD, calculous GB is considered to be one of the risk factors for the recurrence of bile duct stones after sphincterotomy [4,6] . Some studies have compared the results of the wait-andsee policy and prophylactic cholecystectomy to prevent biliary complications but arrived at contradictory results [7][8][9] . Thus, it still remains controversial as to whether subsequent laparoscopic cholecystectomy is indicated in patients with concurrent GB stones. Most studies have focused on the identification of predictors of CBD stone recurrence, which can be treated again endoscopically without surgery; however, the development of acute cholecystitis is a definite indication of cholecystectomy. So the risk factors of subsequent acute cholecystitis are more important than those of recurrent CBD stones in terms of the decision concerning prophylactic cholecystectomy. However, few studies have identified the risk factors of acute cholecystitis after endoscopic CBD stone removal in patients with GB in situ. The aims of this study were to assess the risks of biliary symptom recurrence and to identify the risk factors of acute cholecystitis in patients with GB in situ who have received endoscopic CBD stone removal. MATERIALS AND METHODS PatientsThe medical records of patients with GB in situ who Abstract AIM: To evaluate the risk factors of acute cholecystitis after endoscopic common bile duct (CBD) stone removal.PO Box 2345, Beijing 100023, China World J Gastroenterol 2006 February 14; 12(6): 956-960 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com © 2006 The WJG Press. All rights reserved. RAPID COMMUNICATION METHODS:A total 100 of patients who underwent endoscopic CBD stone removal with gallbladder (GB) in situ without subsequent cholecystectomy from January 2000 to July 2004 were evaluated retrospectively. The following factors were considered while evaluating risk factors for the development of acute cholecystitis: age, gender, serum bilirubin level, GB wall thickening, cystic duct patency, presence of a GB stone, CBD diameter, residual stone, lithotripsy, juxtapapillary diverticulum, presence of liver cirrhosis or diabetes mellitus, a presenting illness of cholangitis or pancreatitis, and procedure-related complications. RESULTS:During a mean 18-mo follow-up, 28 (28%) patients developed biliary symptoms; 17 (17%) acute cholecystitis and 13 (13%) CBD stone recurrence. Of patients with acute cholecystitis, 15 (88.2%) received laparoscopic cholecystectomy and 2 (11.8%) open cholecystectomy. All recurrent CBD stones were successfully removed endoscopically. The mean time elapse to acute cholecystitis was 1...

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“…Acute cholecystitis occurs secondary to cholelithiasis in greater than 90% of cases due to prolonged obstruction of the cystic duct, typically in a gallbladder filled with bile supersaturated with cholesterol [1,2]. Acalculous cholecystitis accounts for the remaining cases.…”

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confidence: 99%

Functional evaluation of cystic duct patency with Gd-EOB-DTPA MR imaging: an alternative to hepatobiliary scintigraphy for diagnosis of acute cholecystitis?

et al. 2011

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Roles of lithogenic bile and cystic duct occlusion in the pathogenesis of acute cholecystitis

Cited by 69 publications

References 13 publications

Effect of Acalculous Cholecystitis on Gallbladder Neuromuscular Transmission and Contractility

Effect of Acalculous Cholecystitis on Gallbladder Neuromuscular Transmission and Contractility

Risk factors of acute cholecystitis after endoscopic common bile duct stone removal

Functional evaluation of cystic duct patency with Gd-EOB-DTPA MR imaging: an alternative to hepatobiliary scintigraphy for diagnosis of acute cholecystitis?

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