Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors

Wang, Ai-ting; Liang, Desheng; Liu, Yujie; Qi, Xian

doi:10.1016/j.biomaterials.2015.02.077

Cited by 102 publications

(54 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The modified block copolymers were amphiphiles, which self-assembled into polymeric micelles in aqueous solution. The quantitative micellization was measured by critical micelle concentration (CMC), which indicated the stability of micelles [32]. The CMCs of mPEG-PCL, mPEG-PCL-CIN, mPEG-PCL-COU and mPEG-PCL-CHR micelles were 2.92, 1.13, 1.08, 0.98 µg/mL (Table 1), respectively.…”

Section: Resultsmentioning

confidence: 99%

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

et al. 2015

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

et al. 2015

View full text Add to dashboard Cite

“…10,11 Many strategies aiming at effective reversal of MDR have been investigated through the co-delivery of chemotherapeutic agents and P-gp inhibitor by nanoparticles. 6,[12][13][14][15] For example, Wang et al 16 reported that polymeric micelles co-encapsulated with PTX and tacrolimus (a P-gp inhibitor) (P-F/M) could improve intracellular concentration of PTX and showed much stronger cytotoxicity against PTX-resistant human ovarian cancer A2780/PTX cells than PTX-loaded micelles. Unfortunately, the P-gp inhibitor actions in a concentration-dependent manner and the simultaneous release…”

Section: Introductionmentioning

confidence: 99%

pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

Huo¹,

Zhu²,

Niu³

et al. 2017

IJN

View full text Add to dashboard Cite

Multidrug resistance (MDR) remains a major challenge for providing effective chemotherapy for many cancer patients. To address this issue, we report an intelligent polymer-based drug co-delivery system which could enhance and accelerate cellular uptake and reverse MDR. The nanodrug delivery systems were constructed by encapsulating disulfiram (DSF), a P-glyco-protein (P-gp) inhibitor, into the hydrophobic core of poly(ethylene glycol)- block -poly( l -lysine) (PEG- b -PLL) block copolymer micelles, as well as 2,3-dimethylmaleic anhydride (DMA) and paclitaxel (PTX) were grafted on the side chain of l -lysine simultaneously. The surface charge of the drug-loaded micelles represents as negative in plasma (pH 7.4), which is helpful to prolong the circulation time, and in a weak acid environment of tumor tissue (pH 6.5–6.8) it can be reversed to positive, which is in favor of their entering into the cancer cells. In addition, the carrier could release DSF and PTX successively inside cells. The results of in vitro studies show that, compared to the control group, the DSF and PTX co-loaded micelles with charge reversal exhibits more effective cellular uptake and significantly increased cytotoxicity of PTX to MCF-7/ADR cells which may be due to the inhibitory effect of DSF on the efflux function of P-gp. Accordingly, such a smart pH-sensitive nanosystem, in our opinion, possesses significant potential to achieve combinational drug delivery and overcome drug resistance in cancer therapy.

show abstract

“…Moreover, TPGS has been used as an excipient for overcoming multidrug resistance (MDR) and as an inhibitor of P-gp. 17 A nonionic surfactant called Solutol HS 15 (polyoxyethylene esters of 12-hydroxystearic acid) is structurally made by fusing fatty acids and end-capped methoxy polyethylene glycol (mPEG), which are connected via chemically and biologically labile linkers. Solutol HS 15 is a new type of amphiphilic surfactant showing high performance, low toxicity, and excellent biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

Yan¹,

Zhang²,

Jia³

et al. 2016

IJN

View full text Add to dashboard Cite

Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with d -α-tocopheryl polyethylene glycol succinate and Solutol HS 15 (BTSM) has been developed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small-cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of ~62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BTSM displayed a more potent anti-proliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration was 7.83 vs 20.37 µg/mL, respectively. The antitumor efficacy test in nude mice showed that BTSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues. The imaging study for in vivo targeting demonstrated that the mixed micelles formulation achieved effective and targeted drug delivery. Therefore, BTSM might be a potential antitumor formulation.

show abstract

Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors

Cited by 102 publications

References 52 publications

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

Contact Info

Product

Resources

About

Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors

Cited by 102 publications

References 52 publications

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

D-&alpha;-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

Contact Info

Product

Resources

About

D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation