Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome

Grulet, H.; Hécart, A.C.; Delemer, B.; Gross, Alan J.; Sulmont, V.; Leuténegger, M; Caron, Jean

doi:10.1111/j.1365-2265.1993.tb02144.x

Cited by 63 publications

(31 citation statements)

References 35 publications

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“…Interestingly, our study is also the first to show an association between VDR TaqI "CC" genotype and serum levels of LH. The molecular mechanism through which this polymorphism influences LH levels is not known at present; however, previous studies have shown significant associations between VDR gene variants and insulin resistance on one side [18], and insulin resistance and LH on the other [19]. Furthermore, it has been suggested a modulating role of 1, 25(OH) 2 D in the control of FSH secretion [20].…”

Section: Discussionmentioning

confidence: 98%

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Ranjzad

Mahban

Shemirani

et al. 2010

J Assist Reprod Genet

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Purpose The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Methods Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH) 2 D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed.Results The VDR TaqI "CC" genotype was associated with elevated serum levels of LH (p=0.011). There were significant associations between decreased levels of SHBG and both VDR BsmI "GG" (p=0.009) and ADIPOQ BsmI "CC" (p=0.016) genotypes. Furthermore, patients with CaSR Hin1I "TG" genotype showed higher HoMA-IR (p=0.008). All these associations remained significant after Bonferroni correction. In addition, phosphorus correlated negatively with estradiol (r=−0.298, P=0.026) and positively with glucose (r=0.287, P=0.032). Conclusions These data indicated for the first time that it is possible that the VDR and CASR gene variants through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS.

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Section: Discussionmentioning

confidence: 98%

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Ranjzad

Mahban

Shemirani

et al. 2010

J Assist Reprod Genet

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“…Both fasting 31,44,73,74 and glucose-stimulated 31,75 insulin concentrations are in fact significantly higher in obese than in non-obese PCOS subgroups. Accordingly, studies examining insulin sensitivity by using different methods such as the euglycemic hyperinsulinemic clamp technique, 44,75 the frequent sample intravenous glucose test (FSivGT) 31,74 and the insulin test 76 further demonstrated that obese PCOS women had significantly lower insulin sensitivity than their non-obese PCOS counterparts and, therefore, a more severe insulin-resistant state. The percentage of women affected by PCOS and obesity presenting glucose intolerance is rather high, ranging from 20 to 49%, 15 therefore substantially above the prevalence rates reported in premenopausal women in population-based studies.…”

Section: Androgen Abnormalitiesmentioning

confidence: 99%

Obesity and the polycystic ovary syndrome

et al. 2002

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The polycystic ovary syndrome (PCOS) is a condition characterized by hyperandrogenism and chronic oligo-anovulation. However, many features of the metabolic syndrome are inconsistently present in the majority of women with PCOS. Approximately 50% of PCOS women are overweight or obese and most of them have the abdominal phenotype. Obesity may play a pathogenetic role in the development of the syndrome in susceptible individuals. In fact, insulin possesses true gonadotrophic function and an increased insulin availability at the level of ovarian tissue may favour excess androgen synthesis. Obesity, particularly the abdominal phenotype, may be partly responsible for insulin resistance and associated hyperinsulinemia in women with PCOS. Therefore, obesity-related hyperinsulinemia may play a key role in favouring hyperandrogenism in these women. Other factors such as increased estrogen production rate, increased activity of the opioid system and of the hypothalamic-pituitary-adrenal axis, decreased sex hormone binding globulin synthesis and, possibly, high dietary lipid intake, may be additional mechanisms by which obesity favours the development of hyperandrogenism in PCOS. Irrespective of the pathogenetic mechanism involved, obese PCOS women have more severe hyperandrogenism and related clinical features (such as hirsutism, menstrual abnormalities and anovulation) than normal-weight PCOS women. This picture tends to be more pronounced in obese PCOS women with the abdominal phenotype.Body weight loss is associated with beneficial effects on hormones, metabolism and clinical features. A further clinical and endocrinological improvement can also be achieved by adding insulin-sensitizing agents and=or antiandrogens to weight reduction programmes. These obviously emphasize the role of obesity in the pathophysiology of PCOS.

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“…그러나, 다낭성난소증후군 환자에서 이러한 부 적절한 성선자극호르몬의 분비 이상은 모든 다낭성난소증후군 환자의 공통된 특성이 아니고 약 50-60% 이하에서 존재하는 것으로 보고되 어 왔다 [6,7].…”

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“…그러나 이러한 성선자극호르몬 분비 이상이 다낭성 난소증후군 환자에서 어떠한 역할을 하는 지에 관해서는 여전히 논란 이 있다. 몇몇 연구들에서 다낭성난소증후군 환자에서 LH 및 LH/FSH 비는 체질량지수, 체중, 인슐린 저항성(insulin resistance)과 음의 상관 관계를 보인다고 보고되어 왔다 [7,[11][12][13]. 반면, 다낭성난소증후군 환 자에서 부적절한 성선자극호르몬 분비는 인슐린 저항성이나 보상성의 고인슐린혈증의 결과가 아니며 독립적이라는 보고들도 있다 [14].…”

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Inappropriate gonadotropin secretion in polycystic ovary syndrome: The relationship with clinical, hormonal and metabolic characteristics

Shim

Hwang

Lim

et al. 2011

Korean J Obstet Gynecol

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ObjectiveTo evaluate the clinical, hormonal and metabolic characteristics according to luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in women with polycystic ovary syndrome (PCOS). MethodsA total of 225 women with PCOS were included in this study. They were divided into two groups according to LH/FSH ratio; group A (LH/FSH < 2, n=160) and group B (LH/FSH > 2, n=65). We compared clinical, hormonal and metabolic characteristics including age at menarche, body mass index (BMI), blood pressures, ovarian volume, and serum androgen levels between the two groups. Serum glucose and insulin levels, fasting glucose/insulin ratio, homeostatic model assessment of insulin resistance (HOMA-IR), and lipid profi les were also compared between the two groups. Pearson correlation coeffi cients were used to evaluate correlation between the LH/FSH ratio and various parameters. ResultsAge of menarche in the group B was signifi cantly later than that in the group A. BMI, waist-hip ratio and blood pressures were signifi cantly lower in the group B compared to those of the group A. Ovarian volume and serum levels of LH, estradiol, total testosterone, sex-hormone binding globulin, 17-hydroxyprogesterone (OHP), and high density lipoprotein were signifi cantly higher in the group B. Postprandial 2 hours glucose, insulin and HOMA-IR were signifi cantly higher in the group A. After adjustment of BMI, the LH/FSH ratio was signifi cantly positively correlated with age at menarche, ovarian volume, total testosterone levels, and 17-OHP levels. ConclusionThe inappropriate gonadotropin secretion may be negatively correlated with BMI, and positively with age of menarche and increased ovarian androgen production irrespective of BMI in women with PCOS. However, it may not be associated with metabolic characteristics.

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Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome

Abstract: PCOS was associated with a significant decrease of insulin sensitivity, independent of obesity. The correlation between LH and insulin sensitivity suggests a complementary action in PCOS.

Cited by 63 publications

References 35 publications

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

Obesity and the polycystic ovary syndrome

Inappropriate gonadotropin secretion in polycystic ovary syndrome: The relationship with clinical, hormonal and metabolic characteristics

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