Abstract:Pattern-recognition receptors detect pathogen-associated molecular patterns to trigger downstream pathways leading to type I IFN and inflammatory cytokines production to defend pathogen infection. RIG-I-like receptors (RLRs) are key cytosolic sensors for recognizing viral RNA to trigger antiviral immunity. The underlying mechanisms linking RLR-mediated viral recognition to antiviral immunity remain to be further explored. Through our previous work, we uncovered an innate immune regulator termed TAPE (TBK1-Asso… Show more
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