Roles of Inflammasome in Cigarette Smoke-Related Diseases and Physiopathological Disorders: Mechanisms and Therapeutic Opportunities

Long, Yingjiao; Yan, Chen

doi:10.3389/fimmu.2021.720049

Cited by 18 publications

(14 citation statements)

References 65 publications

(139 reference statements)

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“…Although other air pollutants have been shown to activate NLRP3 inflammasome and mediate pulmonary, cardiovascular, and neurodegenerative diseases (Saresella et al 2016 ; Zheng et al 2018 ; Du et al 2019 ), the effect of CS on the activation/inhibition of NLRP3 is still controversial and under debate. For instance, NLRP3 has been found to be negatively modulated by CS exposure in human THP1 cells and in mice (Han et al 2017 ; Buscetta et al 2020 ), whereas other studies indicate NLRP3 activation upon CS insult in bronchial epithelial cells and other pathologies as atherosclerosis, vascular and bladder dysfunctions, or brain injury (Li et al 2019 ; Mehta et al 2020 ; Rumora et al 2020 ; Wu et al 2020 ; Ma et al 2021 ). To our knowledge, the effect of CS on assembly and activation of skin inflammasome has never been described yet.…”

Section: Discussionmentioning

confidence: 99%

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Prieux

Ferrara

Cervellati

et al. 2022

In Vitro Cell.Dev.Biol.-Animal

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Cigarette smoke (CS) alters cutaneous biological processes such as redox homeostasis and inflammation response that might be involved in promoting skin inflammatory conditions. Exposure to CS has also been linked to a destabilization of the NLRP3 inflammasome in pollution target tissues such as the lung epithelium, resulting in a more vulnerable immunological response to several exogenous and endogenous stimuli related to oxidative stress. Thus, CS has an adverse effect on host defense, increasing the susceptibility to develop lung infections and pathologies. In the skin, another direct target of pollution, inflammasome disorders have been linked to an increasing number of diseases such as melanoma, psoriasis, vitiligo, atopic dermatitis, and acne, all conditions that have been connected directly or indirectly to pollution exposure. The inflammasome machinery is an important innate immune sensor in human keratinocytes. However, the role of CS in the NLRP1 and NLRP3 inflammasome in the cutaneous barrier has still not been investigated. In the present study, we were able to determine in keratinocytes exposed to CS an increased oxidative damage evaluated by 4-HNE protein adduct and carbonyl formation. Of note is that, while CS inhibited NLRP3 activation, it was able to activate NLRP1, leading to an increased secretion of the proinflammatory cytokines IL-1β and IL-18. This study highlights the importance of the inflammasome machinery in CS that more in general, in pollution, affects cutaneous tissues and the important cross-talk between different members of the NLRP inflammasome family.

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Section: Discussionmentioning

confidence: 99%

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Prieux

Ferrara

Cervellati

et al. 2022

In Vitro Cell.Dev.Biol.-Animal

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“…The activation of these inflammasomes promotes pulmonary injury, contributing to the development of pulmonary fibrosis and inflammation [31]. However, other chemicals present in cigarette smoke, including nicotine and pollutants can also activate the NLRP3 inflammasome in human bronchial and alveolar epithelial cells [32][33][34].…”

Section: Inflammasomes In Lung Cancer Initiationmentioning

confidence: 99%

Inflammasomes driven inflammation in lung cancer revisited: a short review

Costa

Souza

Teixeira³

et al. 2023

Explor Immunol

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Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by inducing pulmonary inflammation. Among the complex features of inflammatory processes, the role of inflammasomes has attracted increasing attention due to their role in different stages of carcinogenesis. Inflammasomes are intracellular multiprotein complexes that when activated promote the maturation of interleukin-1beta (IL-1β) and IL-18, pro-inflammatory cytokines involved in the promotion, progression, epithelial-mesenchymal transition, metastasis, and resistance to therapy of lung cancer. In this way, this review summarizes the recent findings of inflammasome research in different stages of lung cancer, with a focus on non-small cell lung carcinoma (NSCLC), and highlights these multiprotein complexes as promising targets for cancer therapy.

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“…Arglabin inhibits the activation of NLRP3 inflammasome in macrophages, thus having an anti-inflammatory effect on atherosclerosis-prone mice by lowering serum levels of IL-1β [214]. NLRP3 inflammasomes are involved in cigarette-smoke-induced atherosclerosis [215]. Cigarette smoke activates NLRP3 inflammasome in monocytes, macrophages, and foam cells [216,217] Embolization of cholesterol crystals from atherosclerotic lesions of the major arteries causes the appearance of cholesterol-embolization syndrome, known as a systemic disease [218,219].…”

Section: Role Of Nlrp3 Inflammasome In Atherosclerosismentioning

confidence: 99%

Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field

Adam¹,

Șalaru

Prisacariu

et al. 2022

IJMS

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The atherosclerotic vascular disease is a cardiovascular continuum in which the main role is attributed to atherosclerosis, from its appearance to its associated complications. The increasing prevalence of cardiovascular risk factors, population ageing, and burden on both the economy and the healthcare system have led to the development of new diagnostic and therapeutic strategies in the field. The better understanding or discovery of new pathophysiological mechanisms and molecules modulating various signaling pathways involved in atherosclerosis have led to the development of potential new biomarkers, with key role in early, subclinical diagnosis. The evolution of technological processes in medicine has shifted the attention of researchers from the profiling of classical risk factors to the identification of new biomarkers such as midregional pro-adrenomedullin, midkine, stromelysin-2, pentraxin 3, inflammasomes, or endothelial cell-derived extracellular vesicles. These molecules are seen as future therapeutic targets associated with decreased morbidity and mortality through early diagnosis of atherosclerotic lesions and future research directions.

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Roles of Inflammasome in Cigarette Smoke-Related Diseases and Physiopathological Disorders: Mechanisms and Therapeutic Opportunities

Cited by 18 publications

References 65 publications

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Inflammasomes driven inflammation in lung cancer revisited: a short review

Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field

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