Roles ofMoringa oleiferaLeaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats

Abstract

It is common for food to be made more palatable through the use of the flavour enhancer monosodium glutamate, also known as vetsin powder. The purpose of the study described in this paper was to explore how vetsin-induced hepatic toxicity, DNA fragmentation, damage, and oxidative stress modifications could be mitigated with moringa leaf extract (MLE). To that end, 40 male rats were separated into four groups: normal control, positive control or MLE, vetsin, and vetsin combined with MLE. Results indicated that, compared to the control group, the levels of serum alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), liver malondialdehyde (MDA), DNA damage, injury, PCNA, and P53 expressions were significantly enhanced by the administration of vetsin (P < 0.05). However, the vetsin group had significantly reduced levels of albumin, globulin, total protein, liver glutathione (GSH), superoxide dismutase enzyme (SOD), catalase, and glutathione S-transferase (GST) enzyme activities (P < 0.05) by comparison to control. Meanwhile, modifications in liver functions, oxidative stress, DNA damage, liver injury, and PCNA expression were alleviated when vetsin was administered alongside MLE. The authors conclude that vetsin may have many side effects and that MLE can ameliorate biochemical changes, oxidative stress, hepatic injury, PCNA, and P53 alterations induced by vetsin administration.

Possible Mechanism of Aframomum Sceptrum Extracts Mediated Modulation of Renal Function after Monosodium Glutamate Exposure

“…1). This is consistent with similar reports of the ability of some plant materials (Piper longum Linn and Moringa oleifera) to mitigate renal and hepatic malfunction induced by MSG [42,43].…”

Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis

“…MSG caused histological alteration like tissue tightening in kidney of rodent model and also actuated damage in liver and kidney 8 . High dietary intake of MSG as flavor enhancer in rat stimulates liver toxicity by alteration of oxidative stress parameters associated with DNA fragmentation and proliferating cell nuclear antigen alterations 9 . Moreover, MSG in high fat diet is reported to promote kidney damage by altering the gut microbiota and this can leads to one of the noncommunicable disorder like chronic kidney disease 10 .…”

Evaluation of the ameliorative effects of Phyllanthus niruri on the deleterious insecticide imidacloprid in the vital organs of chicken embryos

“…In case of an inflamed pancreas, the quantity of amylase is disturbed. Different enzymes are used as biomarkers in organ function tests; the AST, ALT and gamma-glutamyl transferase (GGT) are biomarkers of liver damage [40] , these are increased in serum after hepatic injury or toxicity. Serum pancreatic amylase is mainly used to diagnose acute pancreatitis or a flare-up of chronic pancreatitis [41] .…”