Abstract:Although mounting evidence suggests a role for G12 proteins, Gα12 and Gα13, in tumor progression, a direct role of G12 proteins has not been determined. This study aims to elucidate the molecular mechanism for tumorigenic/invasive potential of Gα12/13 in MCF10A human breast epithelial cells. Here we report, for the first time, that Gα12/13 induce upregulation of matrix metalloproteinase(MMP)‐2 leading to the invasive/migratory phenotypes in MCF10A cells. We further show that p53 is an important transcription f… Show more
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