Roles of estrogen receptor, progesterone receptor, p53 and p21 in pathogenesis of pelvic organ prolapse

Bai, Sang Wook; Chung, Doo Yong; Yoon, Jung Mi; Shin, Jong Seung; Kim, Sei Kwang; Park, Ki Hyun

doi:10.1007/s00192-005-1310-9

Cited by 31 publications

(20 citation statements)

References 20 publications

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“…Serum estradiol levels and ER are significantly lower (p < 0.01) in the uterine ligaments of women who had POP than in controls without POP before menopause (8). Also, decreased levels of estrogen and progesterone receptors have been described in postmenopausal POP women compared to asymptomatic ones (p < 0.0001) (9).…”

Section: Introductionmentioning

confidence: 94%

Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause

Shynlova

Bortolini²,

Alarab

2013

Int. braz j urol.

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Objectives: To analyze the expression of genes involved in extracellular matrix (ECM) biogenesis and remodeling in vaginal tissue of women with clinically normal pelvic floor support (defined as controls) according to the phase of menstrual cycle and postmenopausal women with and without pelvic organ prolapse (POP). Materials and Methods:This study examined the expression of matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and the Lysyl oxidase (LOX) family genes in the anterior vaginal wall of Caucasian women by real-time RT-PCR. Initially, mRNA expression was assessed in premenopausal controls in the secretory (group 1, n = 10) vs. proliferative (group 2, n = 8) phase of menstrual cycle. In addition, we compared premenopausal controls in the proliferative phase (group 2) vs. postmenopausal controls (group 3, n = 5). Finally, we analyzed postmenopausal controls (group 3) vs. postmenopausal women with advanced POP (group 4, n = 13). Results: According to the phase of menstrual cycle, MMP1 was significantly reduced (p = 0.003), whereas the expression of TIMP1 and LOXL4 was significantly up-regulated during proliferative phase (both p < 0.01) when compared to the secretory phase in premenopausal control women. Regarding menopausal status/ageing, all MMPs were down--regulated, while TIMP3, TIMP4 and LOXL2 were significantly up-regulated in postmenopausal control women when compared to premenopausal controls (p = 0.005, p = 0.01 and p < 0.001, correspondingly). TIMP4 and LOXL2 mRNA levels were significantly decreased in postmenopausal POP patients compared to asymptomatic postmenopausal controls (p < 0.01 for both). Conclusions: Our results indicate that ovarian cycle and age-related changes influence the expression of genes encoding proteins responsible for ECM metabolism in human vagina. Moreover, POP is associated with alteration in vaginal ECM components after menopause.

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Section: Introductionmentioning

confidence: 94%

Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause

Shynlova

Bortolini²,

Alarab

2013

Int. braz j urol.

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“…Few studies have been done to assess the tissue expression levels of sex steroid hormone receptors in patients with POP. Lower estrogen receptor expression in patients with POP have been found in combination with lower serum concentrations of estrogen [65,71]. In contrast, higher sex steroid hormone receptor expression in POP patients has also been described [72].…”

Section: The Fibroblast In Popmentioning

confidence: 99%

“…The role of estrogen in collagen metabolism in POP As estrogen deficiency is a known risk factor for POP [65], estrogen replacement therapy traditionally has been used to improve structural integrity of the pelvic tissue with favourable effects on urinary incontinence [66][67][68][69]. Previously, estrogen receptors (ER) were identified in the nuclei of connective tissue and of the smooth muscle cells of the bladder trigone, urethra, vaginal mucosa, levator ani stromal and uterosacral ligament.…”

Section: The Fibroblast In Popmentioning

confidence: 99%

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008

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Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level. The objective of this review is to test the hypothesis against recent literature. The method used was a review of literature. The association between POP and connective tissue metabolism is well established. However, the causality of this association is unclear. The characteristics of the pelvic floor connective tissue of POP patients relate to tissue repair. To resolve the question of cause and effect, the role of fibroblasts in producing the extracellular matrix should be clarified. With these data, the use of autologous or allogenic stem cells in the treatment of POP may come in sight. Recent literature supports the hypothesis of Jackson but does not resolve long-standing questions on the aetiology of POP.

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“…Grup içi preoperatif / postoperatif sistosel ve rektosel oranlarına bakıldığında; gerek TAH grubunda, gerekse de TAH±BSO grubunda da anlamlı bir fark izlenmedi (Tablo 3). (10) . Yine ilginç olarak, 2003 yılında Lang ve ark.…”

Section: Introductionunclassified

Histerektomi ile Birlikte Yapilan Bilateral Salpingooferektomiye Bagli Hipoostrojeneizmin Sistorektosel Gelisimine Etkisi

Pekcan

Kokanalı²,

Taşçı³

et al. 2018

GMJ

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ÖZETAmaç: Total abdominal histerektomi (TAH) ile birlikte uygulanan bilateral salpingooferektomi (BSO) operasyonunun postoperatif iyatrojenik olarak gelişen hipoöstrojenemiye bağlı olarak sistosel ya da rektosel gelişimine etkisi olup olmadığını araştırmak. Yöntem: Bu retrospektif çalışmaya 1 Temmuz 2014 -1 Temmuz 2015 tarihleri arasında prolapsus dışı benign nedenlerle TAH±BSO uygulanan hastalar dahil edildi. Hastalarla ilgili preoperatif veriler hastane kayıtlarından toplandı. En az postoperatif bir yılını tamamlayan, 50 tane TAH ve 50 tane TAH±BSO uygulanan hastalara ulaşıldı ve jinekolojik muayeneleri yapıldı. Bulgular: TAH grubundaki hastaların yaş ortalaması (48.08±2.23 yıl) ve menapoz sıklığı (44%) TAH±BSO grubundaki yaş ortalaması (51.46±3.78 yıl) ve menapoz varlığı (90%) değerlerine göre anlamlı derecede daha azdı. Gruplar arasında pre ve postoperatif sistosel ve rektosel dereceleri bakımından istatistiki bir fark yoktu. Benzer şekilde her iki grup içinde pre ve postoperatif sistosel ve rektosel dereceleri açısından da anlamlı bir fark tesbit edilmedi. Ayrıca postoperatif gerek sistosel gerekse de rektosel derecesinde artışa neden olabilecek olası faktörlerin çoklu regresyon analizi sonucunda hastalara ooferektomi uygulanmasının her iki durum için anlamlı birer faktör olarak tesbit edilmedi. Sonuç: TAH ile birlikte yapılan BSO operasyonu sonrası gelişen hipoöstrojenizm postoperatif kısa dönemde sistosel ve rektosel gelişiminde etkin bir faktör değildir. ABSTRACT Aim: The objective of this study was to investigate the effect of total abdominal hysterectomy (TAH) combined with bilateral salpingooferectomy(BSO) due to hypoestrogenism on cystocele or rectocele development in postoperative period. Materials and Method: This retrospective study included patients who underwent TAH ± BSO for non-prolapse benign causes between 01 July 2014 and 01 July 2015. Preoperative data related to the patients were collected from hospital records. Patients who completed at least one postoperative year, 50 patients with TAH and 50 patients with TAH ± BSO were reached and gynecologic examinations were performed. Results: The mean age of the patients in the TAH group (48.08 ± 2.23 years) and the frequency of menopause (44%) were significantly lower than in the TAH ± BSO group (51.46 ± 3.78 years) and menopausal status (90%). There was no statistical difference between the groups in terms of pre-and postoperative cystocele and rectocele grades. Similarly, there was no significant difference between both groups in terms of pre-and postoperative cystocele and rectocele grades. In addition, multiple regression analysis of possible factors that may cause an increase in postoperative cystocele or rectoceles did not reveal a significant factor for either case of oophorectomy. Conclusion: Hipoestrogenism following the BSO operation with TAH is not an effective factor in the development of cystocele and rectocele in the postoperative short period.

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Roles of estrogen receptor, progesterone receptor, p53 and p21 in pathogenesis of pelvic organ prolapse

Cited by 31 publications

References 20 publications

Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause

Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

Histerektomi ile Birlikte Yapilan Bilateral Salpingooferektomiye Bagli Hipoostrojeneizmin Sistorektosel Gelisimine Etkisi

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