Roles of DevBCA-like ABC transporters in the physiology of Anabaena sp. PCC 7120

Shvarev, Dmitry; Maldener, Iris

doi:10.1016/j.ijmm.2019.04.005

Cited by 6 publications

(7 citation statements)

References 51 publications

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“…The hgl layer is made of heterocyst-specific glycolipids (HGLs) and is airtight, restricting oxygen from penetrating into the heterocyst, creating a microoxic environment which is essential for dinitrogen fixation by nitrogenase. 553 , 559 , 561 DevBCA forms a heterocyst-specific glycolipid exporter that is essential for the export and development of the hgl layer. To transfer glycolipids through the Gram-negative cell wall, DevBCA has to recruit a TolC-homologue protein called HgdD, that is encoded by the gene alr2887 .…”

Section: Classes Of Transporter Proteinsmentioning

confidence: 99%

“…Similarly, at least eight separate PAPs appear to dock to the OMF HgdD in Anabaena sp. PCC 7120 553 ( Figure 33 B).…”

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins (Mfps)mentioning

confidence: 99%

“…(B) In Anabaena sp. PCC 7120, 553 the OMF HgdD partners with at least eight different PAP–transporter pairs. Notably, while the tripartite assemblies in Anabaena are dominated by MacB and ABC transporters, the RND-based assemblies are predominantly represented in Salmonella.…”

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins (Mfps)mentioning

confidence: 99%

“…Similarly, at least eight separate PAPs appear to dock to the OMF HgdD in Anabaena sp. PCC 7120 553 (Figure 33B). The existence of a wide range of PAPs that are able to interact with a single OMF indicates that the primacy of the determinants of substrate specificity resides with the specific PAP−transporter pair, although the OMF may provide some limited substrate differentiation.…”

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins...mentioning

confidence: 99%

“…A large group of MacB-like transporters have been described in the multicellular cyanobacteria such as Anabaena and Nostoc (for recent reviews please consult Shvarev and Maldener , ) that have been found to associate with diverse functions covering heterocyst development and diazotrophic growth (e.g., HgdBCD system, DevBCA system, All0809/8/7); iron metabolism (All2652/1); as well as drug resistance (Alr4280/1/2 and Alr3647/8/9). , These systems seem to utilize a single OMF HgdD (see section and associated Figure A for details). One of the better studied examples includes the DevBCA-HgdD. − The pump component genes are devB (alr3710) , coding for the PAP protein; devC (alr3711) , coding for TMD; and devA (alr3712) , coding for the NBD, respectively, and they are positioned on a single operon.…”

Section: Classes Of Transporter Proteinsmentioning

confidence: 99%

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Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

et al. 2021

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Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative organisms are diverse in function, energization, and structural organization. They form continuous conduits spanning both the inner and the outer membrane and are composed of three principal components—the energized inner membrane transporters (belonging to ABC, RND, and MFS families), the outer membrane factor channel-like proteins, and linking the two, the periplasmic adaptor proteins (PAPs), also known as the membrane fusion proteins (MFPs). In this review we summarize the recent advances in understanding of structural biology, function, and regulation of these systems, highlighting the previously undescribed role of PAPs in providing a common architectural scaffold across diverse families of transporters. Despite being built from a limited number of basic structural domains, these complexes present a staggering variety of architectures. While key insights have been derived from the RND transporter systems, a closer inspection of the operation and structural organization of different tripartite systems reveals unexpected analogies between them, including those formed around MFS- and ATP-driven transporters, suggesting that they operate around basic common principles. Based on that we are proposing a new integrated model of PAP-mediated communication within the conformational cycling of tripartite systems, which could be expanded to other types of assemblies.

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Section: Classes Of Transporter Proteinsmentioning

confidence: 99%

“…Similarly, at least eight separate PAPs appear to dock to the OMF HgdD in Anabaena sp. PCC 7120 553 ( Figure 33 B).…”

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins (Mfps)mentioning

confidence: 99%

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins (Mfps)mentioning

confidence: 99%

Section: Periplasmic Adaptor Proteins (Paps)/membrane Fusion Proteins...mentioning

confidence: 99%

Section: Classes Of Transporter Proteinsmentioning

confidence: 99%

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Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

et al. 2021

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SFB 766: 12 years of research on the bacterial cell envelope

Stegmann

Wagner

Schwarz

2019

International Journal of Medical Microbiology

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ABC transporter slr0982 affects response of Synechocystis sp. PCC 6803 to oxidative stress caused by methyl viologen

Luo

Jiao

et al. 2022

Research in Microbiology

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Roles of DevBCA-like ABC transporters in the physiology of Anabaena sp. PCC 7120

Cited by 6 publications

References 51 publications

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

SFB 766: 12 years of research on the bacterial cell envelope

ABC transporter slr0982 affects response of Synechocystis sp. PCC 6803 to oxidative stress caused by methyl viologen

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