“…Oxygen transfer is often considered a limiting factor in such aerobic processes, due to the low solubility of oxygen in the liquid medium (Suresh et al, 2009). The k L a of oxygen is an essential parameter to determine the efficiency of bioreactors and to obtain a successful scale-up (García-Cabrera et al, 2021;Sohail et al, 2008). It is important to mention when determining the k L a and when using this as a scaling criterion, it can have allowed error variations of up to 40% in totally aerobic systems (Linek and Vacek, 1981).…”