Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

Meng, Shumei; Cao, Jun; Feng, Qin; Peng, Jinghua; Hu, Yiyang

doi:10.1155/2013/801457

Cited by 427 publications

(348 citation statements)

References 67 publications

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“…The first two DE mentioned have very valuable biological properties, of which the most important are: antioxidant, antiaggregatory, anti-inflammatory, immunostimulating, and anticancer activities (Nakatani et al 2000;Sato et al 2011;Meng et al 2013). Neochlorogenic acid (an isomer of chlorogenic acid) also shows similar properties (Dewick 1997;Thurow 2012).…”

Section: Introductionmentioning

confidence: 99%

High production of bioactive depsides in shoot and callus cultures of Aronia arbutifolia and Aronia × prunifolia

2018

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Methanolic extracts from calluses and shoots of Aronia arbutifolia and Aronia × prunifolia cultivated in vitro were quantitatively analysed for phenolic acids by DAD-HPLC. The cultures were grown on ten variants of Murashige-Skoog medium variants enriched with various concentrations of growth regulators (GRs), BA and NAA, in the concentration range 0.1-3.0 mg/L. The analysed extracts were confirmed to contain from four to six compounds (depsides-chlorogenic acid, neochlorogenic acid, and rosmarinic acid, and also protocatechuic acid, p-hydroxybenzoic acid, and 3,4-dihydroxyphenylacetic acid). The total amounts of the metabolites varied considerably, depending on the amounts of the GRs in the tested medium variants, and increased in the callus and shoot extracts, respectively, up to 1.7 and 3.2 times (A. arbutifolia), and 2.2 and 2.7 times (A. × prunifolia). Maximum total amounts were confirmed in shoot extracts of both plants (approx. 200 and 600 mg/100 g DW, respectively). The main compounds in A. arbutifolia cultures were the depsides-chlorogenic acid, rosmarinic acid, and neochlorogenic acid (max. 91.94, 77.03, 32.57 mg/100 g DW, respectively). The same depsides dominated quantitatively in the cultures of A. × prunifolia (max. 131.82, 206.62 and 257.39 mg/100 g DW, respectively).

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Section: Introductionmentioning

confidence: 99%

High production of bioactive depsides in shoot and callus cultures of Aronia arbutifolia and Aronia × prunifolia

2018

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“…It was demonstrated that chlorogenic acid had a stimulating effect on glucose uptake in skeletal muscle through the activation of AMPK. This compound also suppressed glucose production and reduced fatty acid synthesis in hepatic cells 29,30 . The lipophilic phytochemicals also played an antidiabetic role.…”

Section: Discussionmentioning

confidence: 89%

Anti-hyperglycaemic and anti-hyperlipidaemic effects of black and red rice in streptozotocin-induced diabetic rats

Tantipaiboonwong¹,

Pintha²,

Chaiwangyen³

et al. 2017

ScienceAsia

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Increasing numbers of diabetic patients, especially those with type II, can link their condition to changes in eating habits. Black rice and red rice are not only a source of carbohydrate but also rich sources of antioxidants, especially proanthocyanidins and anthocyanins. This study determines the effect consuming a black rice extract (BRE) or a red rice extract (RRE) on streptozotocin-induced diabetic rats. Blood levels of glucose, triglycerides, and cholesterol in the diabetic group were determined and compared to that of the control group. The results demonstrate that consumption of BRE, 50 mg/kg body weight (BW), or RRE, 100 mg/kg BW, could significantly reduce the blood glucose level of the diabetic rats after eight weeks. Consumption of BRE, 100 mg/kg BW or RRE, 50 mg/kg BW, also clearly decreased the triglyceride level. The cholesterol level in the diabetic group fed with BRE or RRE decreased as well. Thus daily consumption of black rice, red rice, or having their extracts in food supplements may prevent the onset of diabetes.

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“…We reasoned that better candidates to avoid intraluminal AGE formation by fructose would be known dietary compounds, especially those with poor absorption which get concentrated in the lumen. Chlorogenic acids are a family of esters formed between certain trans cinnamic acids and (−)-quinic acid and are major phenolics compounds in coffee, strawberries, pineapple, apple, sunflower, blueberries [37][38][39][40] . We and others have shown a potent effect of these compounds as glycation inhibitors in model systems under intracellular conditions [27,[41][42].…”

Section: Discussionmentioning

confidence: 99%

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

Gugliucci

Bains

Caccavello

2017

Preprint

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Background: One mechanism by which fructose could exert deleterious effect in metabolism and inflammation is via its potency vis-à-vis de Maillard reaction. We employed simulated stomach and duodenum digestion of ovalbumin to test the hypothesis that indeed AGEs are formed by fructose during simulated digestion of an ubiquitous food protein with intrinsic allergenic potential and under model physiological conditions. Methods: OVA was subjected to simulated gastric and intestinal digestion using standard models, in presence of fructose or glucose (0-100 mM). Peptide fractions were analyzed by fluorescence spectroscopy and intensity at Excitation: λ370 nm, Emission: λ 440nm. Results: AGE adducts form between fructose and OVA which can be found in peptide fractions (< 5 kDa) at times (30 min) and concentration ranges (10 mM) plausibly found in the intestines, whereas no reaction occurs with glucose. The reaction is inhibited by chlorogenic acid at concentrations compatible with those found in the gut. The reaction is inhibited by AG, a specific antiglycation agent. Conclusion: Our proof of principle study shows that fructose-AGE formation on an ubiquitous allergenic protein indeed occurs in one hour and thereby may pave the way for the study of yet another mechanism by Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

Cited by 427 publications

References 67 publications

High production of bioactive depsides in shoot and callus cultures of Aronia arbutifolia and Aronia × prunifolia

High production of bioactive depsides in shoot and callus cultures of Aronia arbutifolia and Aronia × prunifolia

Anti-hyperglycaemic and anti-hyperlipidaemic effects of black and red rice in streptozotocin-induced diabetic rats

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

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