Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Arbour, Nathalie; Prat, Alexandre

doi:10.1002/9781118732748.ch3

Cited by 2 publications

(2 citation statements)

References 76 publications

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“…MS is driven by autoreactive T cells originating either from memory T cells reactivated by contacts with antigens in the environment or from naïve T cells educated at the cervical lymph nodes against myelin or neuronal antigens by Antigen Presenting Cells (APCs) such as Dendritic Cells (DCs). After priming, these CNS-specific reactive CD4 + and CD8 + T cells cross the Blood-Brain Barrier (BBB) and are reactivated by APCs inside the parenchyma [46]. Their migration across the BBB is a crucial and precise step.…”

Section: Cellular Mechanisms Interaction and Dynamic Of Cellsmentioning

confidence: 99%

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

et al. 2023

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Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the central nervous system (CNS), characterized by the loss of myelin within the white matter and cortical fibers, axonopathy, and inflammatory responses leading to consequent sensory-motor and cognitive deficits of patients. While complete resolution of the disease is not yet a reality, partial tissue repair has been observed in patients which offers hope for therapeutic strategies. To address the molecular and cellular events of the pathomechanisms, a variety of animal models have been developed to investigate distinct aspects of MS disease. Recent advances of multiscale intravital imaging facilitated the direct in vivo analysis of MS in the animal models with perspective of clinical transfer to patients. This review gives an overview of MS animal models, focusing on the current imaging modalities at the microscopic and macroscopic levels and emphasizing the importance of multimodal approaches to improve our understanding of the disease and minimize the use of animals.

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Section: Cellular Mechanisms Interaction and Dynamic Of Cellsmentioning

confidence: 99%

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

et al. 2023

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“…16 T cells are the major driving factor of experimental autoimmune encephalitis, a murine MS model; the success of therapies that limit T cell access to the CNS also supports cell-mediated immunity. 17 Moreover, the recent success of B cell-depleting therapies in MS treatment has also suggested a more prominent role of the humoral response in MS pathology. 18 Furthermore, B cells have been shown to activate autoreactive T cells that target the brain.…”

Section: Pathophysiologymentioning

confidence: 99%

Effects of COVID-19 on Multiple Sclerosis Relapse: A Comprehensive Review

Topolski

Soti

2022

Int J Med Stud

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Multiple Sclerosis is a chronic inflammatory disease. It is characterized by demyelinating lesions throughout the central nervous system. Patients suffering from multiple sclerosis constitute a vulnerable population to coronavirus disease-2019. This review focuses on the effects of coronavirus disease-2019 on relapse and symptom exacerbation in multiple sclerosis patients and their treatment. It highlights how the blood-brain barrier may be compromised by severe acute respiratory syndrome coronavirus 2, allowing inflammatory mediators and lymphocytes to infiltrate the central nervous system. This may increase the risk of relapse in multiple sclerosis patients. Also, in patients who did not have a prior history of multiple sclerosis, coronavirus disease-2019 has been found to impact multiple sclerosis onset and pathogenesis. However, more comprehensive research is required to fully understand the interplay between multiple sclerosis and coronavirus disease-2019.

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Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Cited by 2 publications

References 76 publications

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

Effects of COVID-19 on Multiple Sclerosis Relapse: A Comprehensive Review

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