Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes

Lü, Huiling; Wang, Hongwei; Wen, Yujun; Zhang, Muxun; Huang, Lin

doi:10.3748/wjg.v12.i11.1747

Cited by 61 publications

(35 citation statements)

References 27 publications

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“…As expected, adiponectin and leptin were correlated with L/A ratio negatively and positively, respectively. Resistin is another protein secreted by adipocytes and leads to insulin resistance in vitro and in vivo, constituting a possible link between obesity and diabetes (28). In the present study, we found markedly higher serum resistin levels in T2DM patients compared to controls.…”

Section: Discussionsupporting

confidence: 65%

See 1 more Smart Citation

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu

Kebapçı

Kara

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BMI), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.

show abstract

Section: Discussionsupporting

confidence: 65%

“…There were no correlations with age, DM duration, glucose, insulin and HbA1c levels (28,29). Hyperresistinemia would contribute to the pathogenesis of hypertension in patients with T2DM (31).…”

Section: Discussionmentioning

confidence: 83%

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu

Kebapçı

Kara

et al. 2012

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Decreased adiponectin levels in type 2 diabetes may be one of the reasons to cause insulin resistance [23]. The HOMA model is used to quantify insulin resistance and beta-cell function from fasting plasma insulin and glucose concentrations [24].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the serum visfatin and adiponectin levels in patients with type 2 diabetes mellitus

Kara¹,

Uslu²,

Kebapçı³

et al. 2014

Turk J Bioch

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“…In our study, serum resistin strongly correlated with rat insulin sensitivity and resistin was positively correlated with insulin, suggesting that insulin could not inhibit resistin secretion in vivo. A number of factors can regulate resistin secretion, such as glucose, epinephrine, and somatropin [27,30] . Therefore, insulin may regulate resistin although it is not the major regulator.…”

Section: Discussionmentioning

confidence: 99%

A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance

Liu¹,

Fan²,

Qiu³

et al. 2008

WJG

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AIM:To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro . METHODS:Supernatant resistin was measured during differentiation of 3T3-L1 preadipocytes. L6 rat myoblasts and hepatoma cell line H4IIE were used to confirm the cellular function of resistin. Diet-induced obese rats were used as an insulin resistance model to study the relationship of resistin with insulin resistance. RESULTS:Resistin expression and secretion were enhanced during differentiation 3T3-L1 preadipocytes. This cellular differentiation stimulated resistin expression and secretion, but was suppressed by insulin. Resistin also induced insulin resistance in H4IIE hepatocytes and L6 myoblasts. In diet-induced obese rats, serum resistin levels were negatively correlated with insulin sensitivity, but not with serum insulin. 95-100

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Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes

Abstract: Plasma adiponectin and resistin are associated with the disorder of metabolism of glucose and lipid in diabetes. The relationship between these hormone and insulin sensitivity suggests that they may take part in the development of insulin resistance of type 2 diabetes.

Cited by 61 publications

References 27 publications

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Evaluation of the serum visfatin and adiponectin levels in patients with type 2 diabetes mellitus

A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance

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