Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour

O’Mara, Shane M.; Sanchez-Vives, Maria V.; Brotons-Mas, Jorge R.; O’Hare, Eugene

doi:10.1016/j.pnpbp.2009.03.040

Cited by 125 publications

(122 citation statements)

References 60 publications

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“…The Sub remains under-investigated, although the neuroanatomical, neurophysiological, and functional properties of the Sub have been summarized (Swanson et al, 1987;Witter, 2006;O'Mara et al, 2009). …”

Section: Cytoarchitectonicsmentioning

confidence: 99%

“…CA1 and Sub may participate in sequence coding and separation over time. Each may serve actions in a different time domain: ongoing processing being mediated by CA1-entorhinal networks, and longer-lasting processes that require temporal linkage between events, by Sub (Hampson et al, 2000;Lörincz and Buzsaki, 2000;O'Mara et al, 2009). The latter likely includes a reentrance loop through EC (Naber et al, 2001b;Kloosterman et al, 2004).…”

Section: The Concept Of Serial and Parallel Information Processingmentioning

confidence: 99%

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Hippocampal Formation

Cappaert

Strien

Witter

2015

The Rat Nervous System

118

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Section: Cytoarchitectonicsmentioning

confidence: 99%

Section: The Concept Of Serial and Parallel Information Processingmentioning

confidence: 99%

Hippocampal Formation

Cappaert

Strien

Witter

2015

The Rat Nervous System

118

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“…The prelimbic and infralimbic cortical areas are important for executive function including the integration of internal physiological states with salient environmental cues to guide behavior (Heidbreder and Groenewegen 2003;Kesner and Churchwell 2011) and may transmit information about emotional saliency to both the aPVT and pPVT. The ventral subiculum, a poorly understood allocortical area that has also been linked to cognitive modulation of emotions and motivation (Fanselow and Dong 2010;O'Mara et al 2009;Bannerman et al 2004;McNaughton 2006), is in position to specifically influence the aPVT. Indeed, reports showing that neurons in the PVT are activated in rats after being exposed to cues signaling sweetened water reward (Igelstrom et al 2010) or placed in a context associated with a taste aversion (Yasoshima et al 2007), drug reward (Brown et al 1992;Rhodes et al 2005;Dayas et al 2008;Hamlin et al 2009) and footshock (Yasoshima et al 2007;Beck and Fibiger 1995) are consistent with the hypothesis that information about emotional saliency or some aspects of cognitive processes associated with emotionally charged events is transmitted from cortical areas to the PVT.…”

Section: Functional Considerationsmentioning

confidence: 99%

Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus

2011

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The paraventricular nucleus of the thalamus (PVT) is part of a group of midline and intralaminar thalamic nuclei implicated in arousal and attention. Recent research points to anatomical and functional differences between the anterior (aPVT) and posterior PVT (pPVT). The present study re-examines the main sources of brain inputs to the aPVT and pPVT in the rat following iontophoretic injections of the retrograde tracer cholera toxin B (CTb) in the PVT. The location and the number of retrogradely labeled neurons in different regions of the brain were examined to determine which brain areas are likely to exert a strong influence on the aPVT and pPVT. The largest number of labeled neurons was found in layer 6 of the prelimbic, infralimbic and posterior insular cortices following injections in the pPVT. In contrast, the largest number of labeled neurons following injections of CTb in the aPVT was found to be in the hippocampal subiculum and the prelimbic cortex. Other areas of the brain including the reticular nucleus of the thalamus, periaqueductal gray, parabrachial nucleus and dorsomedial nucleus of the hypothalamus were found to contain a more moderate number of neurons following injections of CTb in either the aPVT or pPVT. The results of the present tracing study clearly show that more neurons in the prefrontal cortex and subiculum project to the PVT than neurons from the hypothalamus and brainstem. These results highlight the potential importance of top-down modulation of PVT mechanisms and behavioral functions.

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“…The subiculum is in a pivotal position leading the output of the hippocampal formation. Indeed, subicular lesions in the rat do not affect a general navigational-directional strategy, but impair the integration of spatial information provided by extramaze cues in water maze tasks (Oswald and Good 2000;O'Mara et al 2009). The dorsal striatum is known to be involved in the acquisition and expression of response learning by mediating egocentric behavior (Gold 2004;Packard 2009).…”

Section: Spatial Learning Is Related To Transient Kv4 Up-regulationmentioning

confidence: 99%

Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats

Truchet¹,

Manrique²,

Sréng³

et al. 2012

Learn. Mem.

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Kv4 channels regulate the backpropagation of action potentials (b-AP) and have been implicated in the modulation of longterm potentiation (LTP). Here we showed that blockade of Kv4 channels by the scorpion toxin AmmTX3 impaired reference memory in a radial maze task. In vivo, AmmTX3 intracerebroventricular (i.c.v.) infusion increased and stabilized the EPSP-spike (E-S) component of LTP in the dentate gyrus (DG), with no effect on basal transmission or short-term plasticity. This increase in E-S potentiation duration could result from the combination of an increase in excitability of DG granular cells with a reduction of GABAergic inhibition, leading to a strong reduction of input specificity. Radioactive in situ hybridization (ISH) was used to evaluate the amounts of Kv4.2 and Kv4.3 mRNA in brain structures at different stages of a spatial learning task in naive, pseudoconditioned, and conditioned rats. Significant differences in Kv4.2 and Kv4.3 mRNA levels were observed between conditioned and pseudoconditioned rats. Kv4.2 and Kv4.3 mRNA levels were transiently up-regulated in the striatum, nucleus accumbens, retrosplenial, and cingulate cortices during early stages of learning, suggesting an involvement in the switch from egocentric to allocentric strategies. Spatial learning performance was positively correlated with the levels of Kv4.2 and Kv4.3 mRNAs in several of these brain structures. Altogether our findings suggest that Kv4 channels could increase the signal-to-noise ratio during information acquisition, thereby allowing a better encoding of the memory trace.

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Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour

Cited by 125 publications

References 60 publications

Hippocampal Formation

Hippocampal Formation

Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus

Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats

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