Roles for E-cadherin cell surface regulation in cancer

Petrova, Yuliya; Schecterson, Leslayann; Gumbiner, Barry M.

doi:10.1091/mbc.e16-01-0058

Cited by 219 publications

(184 citation statements)

References 61 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…CHO cells are nonadhesive cells that completely lack Cadherin expression (39, 40). Examining the expression pattern of striatin in these cells revealed that, in contrast to Huh7 cells, striatin expression pattern is cytoplasmic and the high molecular striatin form is absent ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Striatin is a novel modulator of cell adhesion

et al. 2018

View full text Add to dashboard Cite

The adherens junctions (AJs) and tight junctions (TJs) provide critical adhesive contacts between neighboring epithelial cells and are crucial for epithelial adhesion, integrity, and barrier functions in a wide variety of tissues and organisms. The striatin protein family, which are part of the striatin interaction phosphatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles. We have previously shown that striatin colocalizes with the tumor suppressor protein adenomatous polyposis coli in the TJs of epithelial cells. Here we show that striatin affects junction integrity and cell migration, probably through a mechanism that involves the adhesion molecule E‐cadherin. Cells engaged in cell—cell adhesion expressed a high MW‐modified form of striatin that forms stable associations with detergent‐insoluble, membrane‐bound cellular fractions. In addition, striatin has recently been suggested to be a target of the poly (ADP‐ribose) polymerases Tankyrase 1, and we have found that striatin interacts with Tankyrase 1 and is subsequently poly‐ADP‐ribosylated. Taken together, our results suggest that striatin is a novel cell—cell junctional protein that functions to maintain correct cell adhesion and may have a role in establishing the relationship between AJs and TJs that is fundamental for epithelial cell—cell adhesion.—Lahav‐Ariel, L., Caspi, M., Nadar‐Ponniah, P. T., Zelikson, N., Hofmann, I., Hanson, K. K., Franke, W. W., Sklan, E. H., Avraham, K. B., Rosin‐Arbesfeld, R. Striatin is a novel modulator of cell adhesion. FASEB J. 33, 4729–4740 (2019). http://www.fasebj.org

show abstract

Section: Resultsmentioning

confidence: 99%

Striatin is a novel modulator of cell adhesion

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Cancer-associated germline mutations in the E-cadherin gene have been reported in patients with hereditary diffuse gastric cancer 69 . Some of these mutations reportedly affect the adhesive state of the cadherin by interfering with inside-out cadherin signaling, a mechanism whereby binding of intracellular catenins and their phosphorylation status 28 affects the overall conformation of the cadherin complex to induce strong adhesion 70 . Additionally, loss of heterozygosity in 16q22.1, the chromosomal region encoding E-cadherin ( CDH1 ), is frequent in lobular carcinoma of the breast, a subtype characterized by single cell invasion 71 .…”

Section: Cadherin Dysfunction In Cancermentioning

confidence: 99%

A central role for cadherin signaling in cancer

Kourtidis

Pence

et al. 2017

Experimental Cell Research

210

220

View full text Add to dashboard Cite

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion, tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of cell-cell contact, coalesces into macromolecular complexes to form the adherens junctions (AJs), and associates via accessory partners with a subcortical ring of actin to form the apical zonula adherens (ZA). As a master regulator of the epithelial phenotype, E-cadherin is essential for the overall maintenance and homeostasis of polarized epithelial monolayers. Its expression is regulated by a host of genetic and epigenetic mechanisms related to cancer, and its function is modulated by mechanical forces at the junctions, by direct binding and phosphorylation of accessory proteins collectively termed catenins, by endocytosis, recycling and degradation, as well as, by multiple signaling pathways and developmental processes, like the epithelial to mesenchymal transition (EMT). Nuclear signaling mediated by the cadherin associated proteins β-catenin and p120 promotes growth, migration and pluripotency. Receptor tyrosine kinase, PI3K/AKT, Rho GTPase, and HIPPO signaling, are all regulated by E-cadherin mediated cell-cell adhesion. Finally, the recruitment of the microprocessor complex to the ZA by PLEKHA7, and the subsequent regulation of a small subset of miRNAs provide an additional mechanism by which the state of epithelial cell-cell adhesion affects translation of target genes to maintain the homeostasis of polarized epithelial monolayers. Collectively, the data indicate that loss of E-cadherin function, especially at the ZA, is a common and crucial step in cancer progression.

show abstract

“…This appears to be the optimum arrangement concerning the transduction of forces with minimum energy costs. The role of E-cadh in molecular architecture of epithelia has been studied extensively in animal tissues, partially owing to its decisive play in human cancers 31 . In frog and fish embryos, as in others, cadherins are the main adhesion factors responsible for regulating the shape of the embryo and its role has been thoroughly described during epiboly and gastrulation 32– 34 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, due to the mechano-transduction activity coupled to the acto-myosin cytoskeleton remodeling, E-cadh is involved in processes such as cell division orientation in planar polarized epithelia 15 and collective cell migration 16 . Relevant as well is that E-cadh has been characterized as a potent suppressor of invasion and metastasis in epithelia 17 , which are usually located in direct contact with mutagenic and/or carcinogenic agents responsible for 85–90 % of human cancers 18 .…”

Section: Introductionmentioning

confidence: 99%

E-cadherin expression pattern during zebrafish embryonic epidermis development

2018

View full text Add to dashboard Cite

Background: E-cadherin is the major adhesion receptor in epithelial adherens junctions (AJs). On established epidermis, E-cadherin performs fine-tuned cell-cell contact remodeling to maintain tissue integrity, which is characterized by modulation of cell shape, size and packing density. In zebrafish, the organization and distribution of E-cadherin in AJs during embryonic epidermis development remain scarcely described. Methods: Combining classical immunofluorescence, deconvolution microscopy and 3D-segmentation of AJs in epithelial cells, a quantitative approach was implemented to assess the spatial and temporal distribution of E-cadherin across zebrafish epidermis between 24 and 72 hpf. Results: increasing levels of E-cadh protein parallel higher cell density and the appearance of hexagonal cells in the enveloping layer (EVL) as well as the establishments of new cell-cell contacts in the epidermal basal layer (EBL), being significantly between 31 and 48 hpf . Conclusions: Increasing levels of E-cadherin in AJs correlates with extensive changes in cell morphology towards hexagonal packing during the epidermis morphogenesis.

show abstract

Roles for E-cadherin cell surface regulation in cancer

Cited by 219 publications

References 61 publications

Striatin is a novel modulator of cell adhesion

Striatin is a novel modulator of cell adhesion

A central role for cadherin signaling in cancer

E-cadherin expression pattern during zebrafish embryonic epidermis development

Contact Info

Product

Resources

About