Roles and Potential Clinical Applications of Intermediate Filament Proteins in Brain Tumors

Quick, Quincy A.; Paul, Madhumita; Skalli, Omar

doi:10.1016/j.spen.2014.12.005

Cited by 21 publications

(21 citation statements)

References 84 publications

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“…Cytoskeletal proteins play a key role in motility, invasion and proliferation (27). In this study we investigated the cytoskeletal spectraplakin protein, MACF1, as a potential diagnostic and prognostic marker and have evaluated its potential to be a target for glioblastoma therapy.…”

Section: Discussionmentioning

confidence: 99%

Microtubule actin cross-linking factor 1, a novel target in glioblastoma

Afghani

Mehta

Wang

et al. 2016

International Journal of Oncology

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Genetic heterogeneity is recognized as a major contributing factor of glioblastoma resistance to clinical treatment modalities and consequently low overall survival rates. This genetic diversity results in variations in protein expression, both intratumorally and between individual glioblastoma patients. In this regard, the spectraplakin protein, microtubule actin cross-linking factor 1 (MACF1), was examined in glioblastoma. An expression analysis of MACF1 in various types of brain tumor tissue revealed that MACF1 was predominately present in grade III-IV astroctyomas and grade IV glioblastoma, but not in normal brain tissue, normal human astrocytes and lower grade brain tumors. Subsequent genetic inhibition experiments showed that suppression of MACF1 selectively inhibited glioblastoma cell proliferation and migration in cell lines established from patient derived xenograft mouse models and immortalized glioblastoma cell lines that were associated with downregulation of the Wnt-signaling mediators, Axin1 and β-catenin. Additionally, concomitant MACF1 silencing with the chemotherapeutic agent temozolomide (TMZ) used for the clinical treatment of glioblastomas cooperatively reduced the proliferative capacity of glioblastoma cells. In conclusion, the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas.

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Section: Discussionmentioning

confidence: 99%

Microtubule actin cross-linking factor 1, a novel target in glioblastoma

Afghani

Mehta

Wang

et al. 2016

International Journal of Oncology

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“…Recent studies have highlighted novel functions for other intermediate filament proteins within the cells of the nervous system, under normal and pathological conditions [30,31]. These proteins are Synemin (SYNM), Syncoilin (SYNC), and GFAP.…”

Section: Neuronal Cytoskeletonmentioning

confidence: 99%

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

Muñoz-Lasso

Romá‐Mateo

Pallardó

et al. 2020

Cells

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Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the molecular mechanisms underlying neurological diseases and allow us to see beyond our current knowledge for the development of new treatments. The neuronal cytoskeleton can be described as an organelle formed by the three-dimensional lattice of the three main families of filaments: actin filaments, microtubules, and neurofilaments. This organelle organizes well-defined structures within neurons (cell bodies and axons), which allow their proper development and function through life. Here, we will provide an overview of both the basic and novel concepts related to those cytoskeletal proteins, which are emerging as potential targets in the study of the pathophysiological mechanisms underlying neurological disorders.

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“…Cytoskeletal linker proteins play crucial roles in tumor cell motility, invasion and proliferation . Afghani et al .…”

Section: Pathological Characteristic Of Microtubule Actin Cross‐linkimentioning

confidence: 99%

“…(34)(35)(36)(37)(38)(39) Cytoskeletal linker proteins play crucial roles in tumor cell motility, invasion and proliferation. (40) Afghani et al (41) investigated the role of MACF1 in glioblastoma and concluded that MACF1 acted as a latent diagnostic and prognostic indicator of GBM. Downregulation of MACF1 with the interference of a short sequence of RNA inhibited the migration and proliferation of glioblastoma cells.…”

Section: Pathological Characteristic Of Microtubule Actin Cross-linkimentioning

confidence: 99%

Microtubule actin cross‐linking factor 1, a novel potential target in cancer

Miao

Ali

et al. 2017

Cancer Science

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Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, deregulation of the cell cycle as well as resistance to apoptosis. The spectraplakin protein microtubule actin cross‐linking factor 1 (MACF1) plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF1 initiates the tumor cell proliferation, and migration and metastasis in numerous cancers, such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF1 and its critical role in different human cancers. This will be helpful for researchers to investigate the novel functional role of MACF1 in human cancers and as a potential target to enhance the efficacy of therapeutic treatment modalities.

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Roles and Potential Clinical Applications of Intermediate Filament Proteins in Brain Tumors

Cited by 21 publications

References 84 publications

Microtubule actin cross-linking factor 1, a novel target in glioblastoma

Microtubule actin cross-linking factor 1, a novel target in glioblastoma

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

Microtubule actin cross‐linking factor 1, a novel potential target in cancer

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