Roles and mechanisms of Kinesin-6 KIF20A in spindle organization during cell division

Wu, Wenda; Yu, Kun; Zhong, Ning; Xiao, Yu; She, Zhen‐Yu

doi:10.1016/j.ejcb.2018.12.002

Cited by 29 publications

(24 citation statements)

References 82 publications

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“…11 Accordingly, KIF20A was considered a tumour-associated antigen, and its overexpression correlated with the oncogenesis and prognosis of cancers. 12,13 Cancer cells overexpressed KIF20A can be recognized by hosts to initiate immune response, thereby KIF20-derived peptides could be used as a novel immunotherapy agent. 5,14 Several clinical trials using KIF20A vaccine had been performed.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

Retracted: KIF20A silence inhibits the migration, invasion and proliferation of non‐small cell lung cancer and regulates the JNK pathway

Xie

Gao

et al. 2019

Clin Exp Pharma Physio

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Lung cancer is the most frequently-occurring tumour and the leading cause of cancer-related death worldwide. 1 As the predominant type of lung cancer, non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. 2 More than 90% of NSCLC patients are triggered by tumour progression, especially distant metastasis, 3 and metastasis has been a critical contributor to mortality rate. 4 Therefore, exploring potential therapeutic targets of NSCLC metastasis is required for more effective clinical therapies. The kinesin family (KIF) contains 14 super families ranging from kinesin-1 to kinesin-14. Kinesin family member 20A (KIF20A), locates on chromosome 5q31.2 and belongs to kinesin family-6, sharing a highly conserved motor domain with other kinesin family members. 5 KIF20A was up-regulated in malignant tumours but barely expressed in normal organs except the testis and thymus. 6 In 2005, for the first

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Section: R E T R a C T E Dmentioning

confidence: 99%

Retracted: KIF20A silence inhibits the migration, invasion and proliferation of non‐small cell lung cancer and regulates the JNK pathway

Xie

Gao

et al. 2019

Clin Exp Pharma Physio

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“…KIF20A is a member of the kinesin-6 subfamily, and is crucial for cytokinesis and spindle assembly. Its expression pattern is linked to tumor development and prognosis [ 47 ]. KIF2C is responsible for the majority of microtubule plus-end depolymerizing activity in mitotic cells.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Hub Genes and Pathways In Esophageal Carcinoma Based on NCBI’s Gene Expression Omnibus (GEO) Database: A Bioinformatics Analysis

Yu-Jing

Tang

2020

Med Sci Monit

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Background Esophageal carcinoma (ESCA) is a health challenge with poor prognosis and limited treatment options. Our aim is to screen for hub genes and pathways associated with ESCA pathology as diagnostic or therapeutic targets. Material/Methods We downloaded 2 ESCA-related datasets from the Gene Expression Omnibus (GEO) database. Subsequently, differentially expressed genes (DEGs) of ESCA were determined by statistical analysis. Both Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using online analytic tools. Network analysis was employed to construct a protein-protein interaction (PPI) network and to filter hub genes. We evaluated the expression level and impact of hub genes on survival of ESCA patients using the OncoLoc webserver. Results A total of 210 DEGs were identified. The GO analysis showed that the DEGs were enriched in cell division. The KEGG pathway analysis showed DEGs that were enriched in cell cycle regulation, known cancer pathways, the PI3K-Akt signaling pathway, and the cGMP-PKG signaling pathway. The top 10 hub genes were markedly upregulated in ESCA tissue compared with normal esophageal tissue. Moreover, the expression level of the hub genes was different at different pathological stages of ESCA. Further prognostic analysis identified that the top 10 hub genes were related to late survival of ESCA patients, while exhibiting few associations with early survival time. Conclusions The signaling pathways involving the DEGs probably represent the pathological mechanism underlying ESCA. The hub genes were associated with survival of ESCA patients, and as such have the potential to serve as diagnostic indicators and therapeutic targets.

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“…After the knock-out of Kif20 a , it was shown that STS cells became stuck in the G2 phase in this study. In tumors, Kif20 a expression increased significantly, it promoted the growth of tumors and tumor cell lines, and was related to carcinogenesis and aggressiveness 19 . The present study demonstrated that Kif20 a was upregulated in STSs, promoted the growth of STSs, similar to most tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The N-terminal domain mediates motor activity, the coiled coil domain interacts with partner proteins and participates in dimerization. The C-terminal tail domain can also interact with partner proteins and contributes to vesicle transport 19 . The present study found that Kif20 a is isolated in the nucleus during G2 phase, thus preventing the cross-linking and depolymerization of cytoplasmic microtubules 20 .…”

Section: Discussionmentioning

confidence: 99%

Knockdown of Kif20a inhibits growth of tumors in soft tissue sarcoma in vitro and in vivo

Zhu¹,

Jin²,

Zhang³

et al. 2020

J. Cancer

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Kif20a (Kinesin Family Member 20A), plays a role in cell mitosis, cell migration and intracellular transport. Numerous studies have demonstrated that Kif20a is abnormally highly expressed in a variety of tumors and shows poor prognosis. Soft tissue sarcoma (STS) represents a group of malignant tumors with poor prognosis. The role of Kif20a in STSs has not been systematically studied. In the present study, bioinformatics analysis, in vitro and in vivo experiments were conducted to investigate the function of Kif20a in STSs. In bioinformatics analysis higher KIf20a expression indicated a poor prognosis. Functional enrichment analysis indicated that Kif20a may be related to cell cycle, p53 and other signaling pathways. In vitro experiments showed that after the down-regulation of Kif20a, cell proliferation, migration and invasion were decreased, while apoptosis was increased. In vivo experiments revealed that Kif20a affected the proliferation of tumors in tumor-bearing mice. In summary, our findings revealed that Kif20a performs an important role in STS, indicating that it is a potential prognostic biomarker and potentially representing a therapeutic target for the disease.

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Roles and mechanisms of Kinesin-6 KIF20A in spindle organization during cell division

Cited by 29 publications

References 82 publications

Retracted: KIF20A silence inhibits the migration, invasion and proliferation of non‐small cell lung cancer and regulates the JNK pathway

Retracted: KIF20A silence inhibits the migration, invasion and proliferation of non‐small cell lung cancer and regulates the JNK pathway

Integrated Analysis of Hub Genes and Pathways In Esophageal Carcinoma Based on NCBI’s Gene Expression Omnibus (GEO) Database: A Bioinformatics Analysis

Knockdown of Kif20a inhibits growth of tumors in soft tissue sarcoma in vitro and in vivo

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