Role of α-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats

Banudevi, Sivanantham; Giribabu, K.; Venkataraman, P.; Vignesh, C; Aruldhas, M. M.; Arunakaran, J.

doi:10.1016/j.fct.2006.07.017

Cited by 80 publications

(40 citation statements)

References 51 publications

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“…The negative effects of the POP exposure on hepatic α-tocopherol concentrations reported in the present study are in accordance with results from previous studies of mink and Greenland sledge dogs exposed to POPs in their diet (Kirkegaard et al, 2010;Käkelä et al, 1999). Furthermore, inverse associations between PCB burdens and hepatic α-tocopherol have been documented in experimental studies with rodents (Banudevi et al, 2006;Mantyla and Ahotupa, 1993;Twaroski et al, 2001a). In a field study on beluga whales (Delphinapterus leucas), inverse relationships between total PCB concentrations and hepatic α-tocopherol concentrations have been reported (Desforges et al, 2013).…”

Section: Tocopherolsupporting

confidence: 82%

“…POPs may also initiate formation of reactive oxygen species by inducing Cyp-enzymes and oxidation of both endogenous and exogenous substances (Palace et al, 2001(Palace et al, , 1996bTwaroski et al, 2001b). Vitamin E has a dominating role in the antioxidant system of vertebrates (Palace and Werner, 2006), and it has been shown that vitamin E protects against oxidative stress caused by PCB induction of the aryl hydrocarbon receptor and thus Cyp1A upregulation (Banudevi et al, 2006;Slim et al, 1999). It is therefore possible that low hepatic and plasma α-tocopherol concentrations in the POP exposed foxes compared to the controls is due to increased utilisation of α-tocopherol to counteract (or neutralize) the POP induced free radicals (Kirkegaard et al, 2010).…”

Section: Tocopherolmentioning

confidence: 99%

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Concentrations of vitamin A, E, thyroid and testosterone hormones in blood plasma and tissues from emaciated adult male Arctic foxes (Vulpes lagopus) dietary exposed to persistent organic pollutants (POPs)

Rogstad

Sonne

Villanger

et al. 2017

Environmental Research

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A B S T R A C TThe aim of the present study was to investigate the relationships and effects of oral POP exposure on retinol (vitamin A), α-tocopherol (vitamin E), thyroid hormones and testosterone in emaciated adult farmed Arctic foxes. Eight brother-pairs were exposed to either a diet containing naturally POP-contaminated minke whale blubber (Balaenoptera acutorostrata) (n=8), or a control diet containing pig (Sus scrofa) fat as the primary fat source (n=8) for 22 months. In the whale blubber containing feed the ∑POPs concentration was 802 ng/g w.w. and it was 24 ng/g w.w. in control feed. The liver mass was significantly higher and the ratio of FT4 (free thyroxine):FT3 (free triiodothyronine) was significantly lower in the POP exposed group as compared to the control group given feed with pig fat (both p < 0.05). The exposed group revealed lower plasma and liver concentrations of α-tocopherol compared to the control group (both p < 0.05). These results indicate that plasma FT4:FT3 ratio and plasma and liver α-tocopherol are valuable biomarker endpoints for chronic oral POP exposure in wild Arctic foxes. Based on this we suggest that plasma FT4:FT3 ratio and plasma and liver α-tocopherol are valuable biomarker endpoints for chronic POP exposure in wildlife Arctic foxes and that these perturbations may affect their health status.

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Section: Tocopherolsupporting

confidence: 82%

Section: Tocopherolmentioning

confidence: 99%

Concentrations of vitamin A, E, thyroid and testosterone hormones in blood plasma and tissues from emaciated adult male Arctic foxes (Vulpes lagopus) dietary exposed to persistent organic pollutants (POPs)

Rogstad

Sonne

Villanger

et al. 2017

Environmental Research

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“…The compounds, tocopherols and tocotrienols, which belong to the same family of vitamin E have been shown to act as neuroprotective agents in neuronal apoptosis induced by oxidative stress (Sen et al 2000;Osakada et al 2003Osakada et al , 2004. Epidemiological studies (Sano et al 1997; Morris et al 1998) and animal studies (Alvarado et al 2006;Banudevi et al 2006) have argued for the benefits of taking vitamin E and C and eating antioxidant-rich diets, respectively. But results from clinical studies in humans, however, have been controversial.…”

Section: Introductionmentioning

confidence: 97%

Is Vitamin E Toxic to Neuron Cells?

et al. 2009

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Besides acting as potent free radical scavengers, tocopherols and tocotrienols have been known to have non-antioxidant properties such as the involvement of alpha-tocopherol (alphaT) in PKC pathway and the anti-cancer properties of gamma-tocotrienol (gammaT3). This study aims to elucidate whether protective effects shown by alphaT and gammaT3 in H(2)O(2)-induced neuron cultures have anti-apoptotic or pro-apoptotic tendency toward the initiation of neuronal apoptosis. H(2)O(2) is used to induce apoptosis in primary cerebellar neuron cultures which is attenuated by pretreatment of alphaT or gammaT3 at concentrations < or =10 microM. Similar to our previous work, gammaT3 was found to be neurotoxic at concentrations > or =100 microM, whereas alphaT showed no neurotoxicity. Cellular uptake of gammaT3 was higher than that of alphaT. Treating cells simultaneously with either gammaT3 or alphaT and with then H(2)O(2) led to higher expression of Bax and Bcl-2 than in neurons exposed to H(2)O(2) alone. Analysis of Bcl-2/Bax ratio as 'survival index' showed that both pretreatment of gammaT3 and alphaT followed by H(2)O(2) increase the 'survival index' of Bcl-2/Bax ratio compared to H(2)O(2)-treated cells, while treatment of gammaT3 alone decrease the ratio compared to unchanged Bcl2/Bax ratio of similar treatment with alphaT alone. Similar treatment of gammaT3 decreased p53 expression and activates p38 MAPK phosphorylation, whereas alphaT did not alter its expression compared to H(2)O(2)-treated cells. Treating neurons with only gammaT3 or alphaT increased the expression of Bax, Bcl-2, p53, and p38 MAPK compared to control with gammaT3 exerting stronger expression for proteins involved than alphaT. In conclusion, low doses of gammaT3 and alphaT confer neuroprotection to H(2)O(2)-treated neurons via their antioxidant mechanism but gammaT3 has stronger pro-apoptosis tendency than alphaT by activating molecules involved in the neuronal apoptotic pathway in the absence of H(2)O(2).

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“…Furthermore, the damage to fish DNA caused by PFDoA used in the present study might also have occurred due to the production of ROS. ROS such as hydroxyl radical (OH À ), superoxide anion (O 2 À ) and hydrogen peroxide (H 2 O 2 ), have been shown to produce damage such as strand breakage in DNA, enzyme inactivation and sometimes apoptosis (Peña-Llopis et al, 2003;Banudevi et al, 2006). Thus, it is possible that PFDoA could cause alterations in DNA of O. latipes resulting in formation of comets.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of perfluorododecanoic acid (PFDoA) in Japanese medaka

Ayanda

Yang

Zhang

et al. 2018

Knowl. Manag. Aquat. Ecosyst.

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-This study investigated the cytotoxic and genotoxic potential of perfluorododecanoic acid (PFDoA), a perfluorinated carboxylic chemical (PFC) that has broad applications and distribution in the environment in Japanese medaka, Oryzias latipes. Micronucleus (MN) test and Comet assay were used for the toxicity study. Three groups of fish were exposed to 0.1 mg/L, 0.5 mg/L and 2.5 mg/L concentration of the chemical for 28 days. Another group served as control. Sampling of the fish blood and liver were done after days 1, 4, 7, 14, 21 and 28 for analysis of different erythrocyte abnormalities and damage to DNA using the MN test and Comet assay respectively. Results showed that there was a significant time and concentration dependent increase (p < 0.05) in percent tail length of DNA and frequency of erythrocyte abnormalities. Nuclear abnormalities observed include micronucleus, fragmented apoptotic cells, lobed nuclei, and bean-shaped cells. Increase in induction of erythrocyte abnormalities and percent tail length of DNA peaked at days 14 and 7, respectively, after which there was a gradual decline. The results indicate that sub-chronic exposure of PFDoA to Japanese medaka caused DNA damage with a simultaneous induction of different erythrocyte abnormalities.

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Role of α-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats

Cited by 80 publications

References 51 publications

Concentrations of vitamin A, E, thyroid and testosterone hormones in blood plasma and tissues from emaciated adult male Arctic foxes (Vulpes lagopus) dietary exposed to persistent organic pollutants (POPs)

Concentrations of vitamin A, E, thyroid and testosterone hormones in blood plasma and tissues from emaciated adult male Arctic foxes (Vulpes lagopus) dietary exposed to persistent organic pollutants (POPs)

Is Vitamin E Toxic to Neuron Cells?

Cytotoxic and genotoxic effects of perfluorododecanoic acid (PFDoA) in Japanese medaka

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