Role of zinc metalloprotease (ZMPSTE24) in porcine reproductive and respiratory syndrome virus (PRRSV) replication in vitro

Katwal, Pratik; Aftab, Shamiq; Nelson, Eric; Hildreth, Michael B.; Li, Shitao; Wang, Xiuqing

doi:10.1007/s00705-022-05529-0

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZMPSTE24 has been previously shown to defend cells against entry of many, but not all, enveloped viruses ( 5 , 29 , 30 , 54 , 55 ). In the present study, we have extended the range of viruses against which ZMPSTE24 protects to include coronaviruses.…”

Section: Discussionmentioning

confidence: 99%

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Shilagardi¹,

Spear²,

Abraham

et al. 2022

mBio

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Shilagardi¹,

Spear²,

Abraham

et al. 2022

mBio

View full text Add to dashboard Cite

show abstract

“…ZMPSTE24 is another host zinc finger motif containing protein, which shows antiviral activity against many enveloped viruses, including influenza virus, Vesicular stomatitis virus (VSV), Vaccinia virus, Porcine reproductive and respiratory syndrome virus (PRRSV) and arenaviruses ( Fu et al, 2017 ; Katwal et al, 2022 ; Stott-Marshall and Foster, 2022 ). A recent report demonstrates that ZMPSTE24 inhibits infection of SARS-CoV-2-spike pseudotyped lentivirus, suggesting its antiviral function against the SARS-CoV-2.…”

Section: Antiviral Function Of Zinc-containing Host Proteinsmentioning

confidence: 99%

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar,

Ansari,

Narayanan

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Viral hepatitis is a major public health concern globally. World health organization aims at eliminating viral hepatitis as a public health threat by 2030. Among the hepatitis causing viruses, hepatitis B and C are primarily transmitted via contaminated blood. Hepatitis A and E, which gets transmitted primarily via the feco-oral route, are the leading cause of acute viral hepatitis. Although vaccines are available against some of these viruses, new cases continue to be reported. There is an urgent need to devise a potent yet economical antiviral strategy against the hepatitis-causing viruses (denoted as hepatitis viruses) for achieving global elimination of viral hepatitis. Although zinc was known to mankind for a long time (since before Christ era), it was identified as an element in 1746 and its importance for human health was discovered in 1963 by the pioneering work of Dr. Ananda S. Prasad. A series of follow up studies involving zinc supplementation as a therapy demonstrated zinc as an essential element for humans, leading to establishment of a recommended dietary allowance (RDA) of 15 milligram zinc [United States RDA for zinc]. Being an essential component of many cellular enzymes and transcription factors, zinc is vital for growth and homeostasis of most living organisms, including human. Importantly, several studies indicate potent antiviral activity of zinc. Multiple studies have demonstrated antiviral activity of zinc against viruses that cause hepatitis. This article provides a comprehensive overview of the findings on antiviral activity of zinc against hepatitis viruses, discusses the mechanisms underlying the antiviral properties of zinc and summarizes the prospects of harnessing the therapeutic benefit of zinc supplementation therapy in reducing the disease burden due to viral hepatitis.

show abstract

Role of zinc metalloprotease (ZMPSTE24) in porcine reproductive and respiratory syndrome virus (PRRSV) replication in vitro

Cited by 2 publications

References 19 publications

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Contact Info

Product

Resources

About