Role of Vitamins in Skin Health: a Systematic Review

Dattola, Annunziata; Silvestri, Martina; Bennardo, Luigi; Passante, Maria; Scali, Elisabetta; Patruno, Cataldo; Nisticò, Steven Paul

doi:10.1007/s13668-020-00322-4

Cited by 80 publications

(82 citation statements)

References 55 publications

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“…UVR can affect the human system both positively and negatively. The advantages of exposure to UVR are primarily the synthesis of vitamin D [19,20]. The harmful properties of ultraviolet radiation include mainly the effects of this factor on the skin in the form of sunburn, photodermatosis, photoaging, and the formation of precancerous and neoplastic skin lesions.…”

Section: Ultraviolet Radiation and Skin Components Involved In Inflammationmentioning

confidence: 99%

Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

Ciążyńska

Olejniczak-Staruch

Sobolewska-Sztychny

et al. 2021

Life

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The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironment is a condition leading to tumor formation. Multiple studies focus on the molecular pathways activating tumorigenesis by inflammation and indicate several biomarkers and factors that can improve diagnostic and prognostic processes in oncology and dermatology. Reactive oxygen species produced by ultraviolet radiation, oxidizers, or metabolic processes can damage cells and initiate pro-inflammatory cascades. Considering the potential role of inflammation in cancer development and metastasis, the identification of early mechanisms involved in carcinogenesis is crucial for clinical practice and scientific research. Moreover, it could lead to the progress of advanced skin cancer therapies. We focus on a comprehensive analysis of available evidence and on understanding how chronic inflammation and ultraviolet radiation can result in skin carcinogenesis. We present the inflammatory environment as complex molecular networks triggering tumorigenesis and constituting therapeutic targets.

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Section: Ultraviolet Radiation and Skin Components Involved In Inflammationmentioning

confidence: 99%

Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

Ciążyńska

Olejniczak-Staruch

Sobolewska-Sztychny

et al. 2021

Life

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“…Elevated oxidative stress levels, exaggerated immune response due to the cytokine storm, and uncontrollable liberation of proinflammatory cytokines, along with the activation of pre-coagulating factors, all contribute to severe inflammation, which is exaggerated in acute respiratory distress syndrome [ 4 , 5 ]. Vitamin D is a fat-soluble prohormone steroid that has endocrine, paracrine, and autocrine functions [ 6 ]. Recent studies demonstrated that vitamin D could mediate antiviral activity by many actions, including enhancing apoptosis and autophagy as well as by inducing antimicrobial peptides [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents

et al. 2021

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Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising preliminary results, the focus remains on additional preventive measures to manage COVID-19. Results conflict on vitamin D’s plausible role in preventing and treating COVID-19. We examined the relation between vitamin D status and COVID-19 severity and mortality among the multiethnic population of the United Arab Emirates. Our observational study used data for 522 participants who tested positive for SARS-CoV-2 at one of the main hospitals in Abu Dhabi and Dubai. Only 464 of those patients were included for data analysis. Demographic and clinical data were retrospectively analyzed. Serum samples immediately drawn at the first hospital visit were used to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations through automated electrochemiluminescence. Levels < 12 ng/mL were significantly associated with higher risk of severe COVID-19 infection and of death. Age was the only other independent risk factor, whereas comorbidities and smoking did not contribute to the outcomes upon adjustment. Sex of patients was not an important predictor for severity or death. Our study is the first conducted in the UAE to measure 25(OH)D levels in SARS-CoV-2-positive patients and confirm the association of levels < 12 ng/mL with COVID-19 severity and mortality.

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“…There is also growing evidence to suggest that the impact of vitamin D deficiency in the first few years of life may extend to adulthood, when vitamin D deficiency is associated with cancer, cardiovascular disease, or infections including COVID-19 [ 9 , 10 , 11 ]. Vitamin D and its derivatives are also used in the treatment of various medical conditions [ 12 ]. Understanding the epidemiology of vitamin D deficiency in children, especially young infants, is key to the prevention of a broad range of diseases across the lifespan.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study

et al. 2021

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Early-life vitamin D deficiency is associated with adverse child health outcomes, but the prevalence of vitamin D deficiency and its correlates in infants remains underexplored, particularly in sub-Saharan Africa. We aimed to investigate the prevalence of vitamin D deficiency and its correlates among young infants in South Africa. This study included 744 infants, aged 6–10 weeks from the Drakenstein Child Health Study, a population-based birth cohort. Infants were categorized into distinct categories based on serum 25(OH)D concentration level including deficient (<50 nmol/L), insufficient (50–74 nmol/L), and sufficient (≥75 nmol/L). Using multivariable Tobit and logistic regression models, we examined the correlates of serum 25(OH)D3 levels. The overall prevalence of vitamin D deficiency was 81% (95% confidence intervals (CI]) 78–83). Multivariable regression analysis showed that serum 25(OH)D3 concentration was independently associated with study site, socioeconomic status, and sex. Birth in winter and breastfeeding were the strongest predictors of lower serum 25(OH)D3 concentration levels. Compared to non-breastfed children, children breastfed were at higher risk of vitamin D deficiency (AOR, 1.96; 95% CI, 1.04–3.67) and breastfeeding for more than one month was associated with greater likelihood of vitamin D deficiency (AOR, 5.40; 95% CI, 2.37–12.32) and lower vitamin D concentrations (−16.22 nmol/L; 95% CI, −21.06, −11.39). Vitamin D deficiency in infants is ubiquitous, under-recognised, and strongly associated with season of birth and breastfeeding in this setting. Nutritional interventions with vitamin D supplementation in national health programs in low- and middle-income countries are urgently needed to improve early-life vitamin D status in infants.

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Role of Vitamins in Skin Health: a Systematic Review

Cited by 80 publications

References 55 publications

Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review

COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents

Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study

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