Role of vitamin D3 supplementation in allergic rhinitis: an outpatient department based prospective analytical observational study

Abstract

Background: Allergic rhinitis is a common disorder characterized by sneezing, rhinorrhoea, nasal congestion, itching and lacrimation which adversely affect quality of life to a substantial degree. Evidence suggests that low serum vitamin D3 has correlation with severity of allergic rhinitis. The objective of the study was to evaluate whether vitamin D3 supplementation has any role to reduce the severity of disease spectrum among allergic rhinitis patients.Methods: This prospective analytical observational study was carried out in 6 months in ENT OPD of Midnapore medical college and Hospital. Only the persistent moderate to severe allergic rhinitis patients as per ARIA-WHO guideline, aged >12 years were included in this study. 64 subjects were randomised into two groups. The test group received oral vitamin D (60000 IU/week for 2 months) along with levocetirizine, fluticasone spray and montelukast while the control group received three drug therapies without vitamin D3. Allergy symptom score (ASS) was assessed at the start and end of the study period.Results: The study population (n=64) was predominantly female (37) and had a mean age of 39.79 years. The ASS score was 14.06±1.01 in Test group and 13.93±1.01 in Control group and the Post treatment ASS score was 2.65±1.12 and 6.06±0.87 respectively. This difference between groups was significant (p<0.001).Conclusions: There was significant reduction in the Allergy symptom score after vitamin D3 supplementation which alters the course of disease towards clinical improvement.

Role of Vitamin D Supplementation in Allergic Rhinitis

“…Our results were supported by study of Hembrom et al, 2019 [12] as they reported that there was no statistically significant difference between their studied groups as regard age and sex. The age of control group was 40.18±7.81years whereas in Test group the mean age± SD was 39.40±7.58 years.…”

“…Our results were supported by study of Hembrom et al, 2019 [12] as they reported that there was no statistically significant difference between their studied groups as regard serum VD3. The serum VD3 level was 21.24±2.30 IU/ml in control group and 18.25±3.34 IU/ml in test group respectively.…”