Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis

Huang, Jing; An, Qi; Ju, Bomiao; Zhang, Jing; Fan, Ping; Wang, Lei

doi:10.1016/j.intimp.2021.108131

Cited by 16 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such multifaceted roles underscore VDR’s potential as a therapeutic target. For example, in the context of lupus nephritis, a notable condition marked by increased disease activity and severity, a correlation has been observed with decreased VDR expression in renal tissues ( Huang et al, 2021 ). This finding is pivotal as it suggests that VDR not only plays a role in disease manifestation but also in its progression.…”

Section: Vdr and Human Diseasesmentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

The Vitamin D receptor (VDR) is a crucial nuclear receptor that plays a vital role in various physiological functions. To a larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin D or its synthetic analogs to treat non-communicable diseases is insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) and bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae and TCM-derived bioactive compounds have shown promise in modulating VDR activities. This review explores the intriguing potential of TCM and bioactive compounds in modulating VDR activity. We first emphasize the latest information on the genetic expression, function, and structure of VDR, providing a comprehensive understanding of this crucial receptor. Following this, we review several TCM formulae and herbs known to influence VDR alongside the mechanisms underpinning their action. Similarly, we also discuss TCM-based bioactive compounds that target VDR, offering insights into their roles and modes of action.

show abstract

Section: Vdr and Human Diseasesmentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Interestingly, calcitriol attenuates TLR-2 signaling as well as the activation of the NLRP3 inflammasome/NF-kB axis in animal and human models of inflammatory and autoimmune diseases (rheumatoid arthritis and systemic lupus erythematosus) [25][26][27][28].…”

Section: Innate Immunity Activation In Covid-19mentioning

confidence: 99%

Vitamin D and COVID-19: Narrative Review after 3 Years of Pandemic

et al. 2022

View full text Add to dashboard Cite

Active vitamin D [1,25(OH)2D3—calcitriol] is a secosteroid hormone whose receptor is expressed on all cells of the immune system. Vitamin D has a global anti-inflammatory effect and its role in the management of a SARS-CoV-2 infection has been investigated since the beginning of the COVID-19 pandemic. In this narrative review, the laboratory and clinical results of a vitamin D supplementation have been collected from both open-label and blinded randomized clinical trials. The results are generally in favor of the utility of maintaining the serum concentrations of calcifediol [25(OH)D3] at around 40 ng/mL and of the absolute usefulness of its supplementation in subjects with deficient serum levels. However, two very recent large-scale studies (one open-label, one placebo-controlled) have called into question the contribution of vitamin D to clinical practice in the era of COVID-19 vaccinations. The precise role of a vitamin D supplementation in the anti-COVID-19 armamentarium requires further investigations in light of the breakthrough which has been achieved with mass vaccinations.

show abstract

“…Treatment of MRL/lpr mice with VDR agonist paricalcitol mitigated lupus nephritis via modulating the NF-κB/NLRP3/caspase-1/IL-1β/IL-18 axis and suppressing NF-κB nuclear translocation ( 337 ).…”

Section: Macronutrients and Autoimmunitymentioning

confidence: 99%

Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era

Abdelhamid

Luo

2022

Front. Immunol.

View full text Add to dashboard Cite

The immune system is an efficiently toned machinery that discriminates between friends and foes for achieving both host defense and homeostasis. Deviation of immune recognition from foreign to self and/or long-lasting inflammatory responses results in the breakdown of tolerance. Meanwhile, educating the immune system and developing immunological memory are crucial for mounting defensive immune responses while protecting against autoimmunity. Still to elucidate is how diverse environmental factors could shape autoimmunity. The emergence of a world pandemic such as SARS-CoV-2 (COVID-19) not only threatens the more vulnerable individuals including those with autoimmune conditions but also promotes an unprecedented shift in people’s dietary approaches while urging for extraordinary hygiene measures that likely contribute to the development or exacerbation of autoimmunity. Thus, there is an urgent need to understand how environmental factors modulate systemic autoimmunity to better mitigate the incidence and or severity of COVID-19 among the more vulnerable populations. Here, we discuss the effects of diet (macronutrients and micronutrients) and hygiene (the use of disinfectants) on autoimmunity with a focus on systemic lupus erythematosus.

show abstract

Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis

Cited by 16 publications

References 57 publications

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Vitamin D and COVID-19: Narrative Review after 3 Years of Pandemic

Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era

Contact Info

Product

Resources

About