Role of vitamin D in urogenital health of geriatric participants

Abstract

Introduction:Role of Vitamin D is very well known for the functioning of many body organs. However, its role in the postmenopausal women in relation to various genitourinary disorders has been recognized recently. The main objective of this study was to evaluate role of Vitamin D in vaginal health, prolapse, bladder and bowel function, and bacterial vaginosis (BV).Materials and Methods:This was a randomized controlled study in which 200 geriatric female patients of 65–78 years of age divided into two groups comprising study and control group with 100 participants in each. Detailed obstetrical, gynecological, and clinical history was elicited. Detailed examination regarding the prolapse, urinary and bowel functions, and bacterial infections was done followed by follow-up of 3 and 6 months each. Chi-square and independent t-test used for data analysis.Results:Mean modified vaginal health index (MVHI) among patients with pelvic floor diseases was statistically significant with P = 0.0472. There was a visible increasing trend in Vitamin D deficiency with increase in time since menopause (P = 0.1193). Patients with pelvic floor disease had mean Vitamin D statistically significant with P = 0.0462. With increase in Vitamin D levels, MVHI was found to be better. The association of mean Vitamin D levels among patients with urinary incontinence as compared to controls was significant with P = 0.0460. Association of mean Vitamin D levels in patients with fecal incontinence and BV as compared to controls was not statistically significant with P = 0.6304 and 0.79, respectively. Low Vitamin D levels were associated with high mean parathyroid hormone (PTH) levels statistically significant with P = 0.034. MVHI was found to increase significantly with Vitamin D supplementation at 3 and 6 months' follow-up. There was increase in Vitamin D and calcium levels and fall in serum PTH levels at 3 and 6 months.Conclusions:Vitamin D levels were associated with a decreased risk of pelvic floor disorders, improved MVHI in women in geriatric age group.

The Serum Level of Vitamin D in Women With Urinary Incontinence Due to Pelvic Floor Disorder and Prolapse: A Regional Case-Control Study on Iranian Population

“…Contrary to this hypothesis regarding that serum levels of vitamin D should be lower in patients in the case group, namely, those with PFD as compared to the control group (without PFD), the results showed that the mean serum level of the control group and the frequency of vitamin D deficient patients were higher in the control group. These results do not match the results of previous studies on the association of PFD and serum level of vitamin D (26)(27)(28), and also the correlation between the serum levels of vitamin D and urogenital disorders such as UI (20,37) and overactive bladder (21), which have determined lower serum levels of vitamin D in patients with PFD or UI problems. In this study, it was assumed that the patients were of the same social class as they referred to one center and that their dietary nutrition was also similar.…”

“…Also 47% of all the refugees in the world and 50% of asylum seekers and displaced people are women and girls and 44% refugees and asylum seekers are children under the age of 68 muscular dysfunction in pathophysiology of the UI, some studies have investigated the association of vitamin D and urogenital disorders such as UI (20) and overactive bladder (21) while others have focused on the effect of vitamin D supplementation on treatment of UI symptoms (22,23). However, based on the review studies (24), the few investigations exploring this association (25)(26)(27)(28) have several limitations and further studies are required to determine the definite correlation between vitamin D and PFD. Moreover, the prevalence of vitamin D hypovitaminosis and PFD are high among Iranian women and the relationship between these 2 variables has not been investigated in the Iranian population.…”

Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women

“…The study also highlighted a dose-response relationship between the level of 25(OH)D and the occurrence of BV [120]. However, Kaur et al found no association between serum vitamin D levels and BV [121]. Ginkel et al concluded that women on estrogen replacement therapy are less likely to have vaginal colonization with anaerobic bacteria and that estrogen may potentiate the effects of lactobacilli on vaginal pH [122].…”

Resolution of the national interdisciplinary council of experts "High-dose vitamin D (Devilam) in the practice of an obstetrician-gynecologist"

“…Более того, уровень витамина D был обратно пропорционален тяжести пролапса тазовых органов [ 105 ][ 106 ]. Повышение уровня витамина D было связано с уменьшением риска расстройств тазового дна, улучшением среднего модифицированного индекса здоровья влагалища у женщин в возрастной группе 65–78 лет [ 107 ].…”

“…Витамин D может быть полезен при вагинальном дискомфорте у женщин в период менопаузы [ 107 ][ 115 ], однако некоторые экспериментальные результаты противоречивы [ 118 ][ 119 ]. В исследовании 2017 г. было показано, что витамин D обладает фунгицидной активностью в отношении Candida Albicans.…”