Role of vitamin D in chronic hepatitis C

Kim, Tae Yeob

doi:10.3350/kjhep.2011.17.2.170

Cited by 1 publication

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“…The allele frequencies of the gene polymorphic loci studied revealed that the A allele of CYP27B1 was found to be slightly more frequent (66.67%) in patients than in controls, while C allele is more frequent in controls but yet again the difference between two groups was not significant. This result is in agreement with those of previous study that have reported that SVR rates were significantly higher in patients with CYP27B1-1260 genotype AA and AC compared to CYP27B1-1260 genotype CC (77% and 65% versus 42% respectively; P= 0.02) [27] . This finding is in consistent with the study of Lange et al , which reported that the genotype CC was more frequent in patients with chronic hepatitis C compared to healthy populations in European cohort of patients with chronic hepatitis C. Results of the current study show that there was no statistically significant difference between patients with chronic hepatitis C and normal controls according to allelic distribution (p>0.05).…”

Section: Discussionsupporting

confidence: 93%

Association of Serum Vitamin D and Cytochrome P450 27B1 Gene Polymorphism in Viral Hepatitis C Patients

2015

Egyptian Journal of Pure and Applied Science

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Hepatitis C virus (HCV) is a leading cause of chronic liver disease in the world, making this disease a significant cause of morbidity and mortality. This study aimed to evaluate the interrelation between the vitamin D serum level and the functional polymorphism of 1-alpha hydroxylase (CYP27B1) in the response of chronic HCV patients to treatment. The study was conducted in the Medical Research Centre, Faculty of Medicine, Ain Shams University, and included thirty patients diagnosed as chronic hepatitis C who were treated with pegylated interferon (PEG-IFN) and ribavirin (RBV) combination therapy. Twenty healthy subjects were also included as a control group. These patients were divided into two groups; responders (10 patients) and non-responders (20 patients). The blood samples were taken for assay of vitamin D level and CYP27B1 polymorphism. The results revealed that chronic HCV patients were suffering from deficiency of both 25(OH)-vitamin D and 1,25 dihydroxyvitamin D (1,25(OH) 2 D), but with respect to CYP27B1 genetic polymorphism, no specific genotype for chronic HCV patient. However, responders with genotype AA of the CYP27B1 had higher serum concentrations of 1,25(OH) 2 D than the responders with genotypes AC and CC. In conclusion, HCV-infected patients carrying homozygous AA of the CYP27B1 have higher chances to respond to (PEG-IFN)-based treatment.

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Section: Discussionsupporting

confidence: 93%

Association of Serum Vitamin D and Cytochrome P450 27B1 Gene Polymorphism in Viral Hepatitis C Patients

2015

Egyptian Journal of Pure and Applied Science

View full text Add to dashboard Cite

show abstract

Role of vitamin D in chronic hepatitis C

Cited by 1 publication

References 16 publications

Association of Serum Vitamin D and Cytochrome P450 27B1 Gene Polymorphism in Viral Hepatitis C Patients

Association of Serum Vitamin D and Cytochrome P450 27B1 Gene Polymorphism in Viral Hepatitis C Patients

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