Role of vitamin D and sFlt-1/PlGF ratio in the development of early- and late-onset preeclampsia

Álvarez-Fernández, Indira; Prieto, Belén; Rodríguez, Verónica; Ruano, Yolanda; Escudero, Ana I; Álvarez, Francisco V.

doi:10.1515/cclm-2014-1039

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…In our study setting, one of the common indications for caesarean section is pre-eclampsia, the prevalence of which has been associated with VDD. [39][40][41] The low…”

Section: Research Discussionmentioning

confidence: 99%

Maternal and neonatal vitamin D status at birth in black South Africans

et al. 2019

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“…In our study setting, one of the common indications for caesarean section is pre-eclampsia, the prevalence of which has been associated with VDD. [39][40][41] The low…”

Section: Research Discussionmentioning

confidence: 99%

Maternal and neonatal vitamin D status at birth in black South Africans

et al. 2019

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“…In a prospective study, biochemical and/or biophysical markers of PE development did not differ among first trimester gravidae with or without low vitamin D status [ 43 ]. Nonetheless, retrospective analysis has shown an increased risk of late-onset, but not early-onset, PE among women with low vitamin D status at clinical presentation despite no difference in first trimester 25(OH)D concentrations between PE complicated and non-PE complicated pregnancies [ 44 ]. The decrease in 25(OH)D status in late pregnancy among the PE group contrasts to the increase observed for the undiagnosed group, again emphasising the possibility that vitamin D is implicated in PE development in late gestation, independent of differences in the multiple mechanistic pathways of PE pathogenesis in early pregnancy [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy

O'Callaghan

Kiely

2018

Nutrients

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This narrative systematic review evaluates growing evidence of an association between low maternal vitamin D status and increased risk of hypertensive disorders. The inclusion of interventional, observational, and dietary studies on vitamin D and all hypertensive disorders of pregnancy is a novel aspect of this review, providing a unique contribution to an intensively-researched area that still lacks a definitive conclusion. To date, trial evidence supports a protective effect of combined vitamin D and calcium supplementation against preeclampsia. Conflicting data for an association of vitamin D with gestational hypertensive disorders in observational studies arises from a number of sources, including large heterogeneity between study designs, lack of adherence to standardized perinatal outcome definitions, variable quality of analytical data for 25-hydroxyvitamin D (25(OH)D), and inconsistent data reporting of vitamin D status. While evidence does appear to lean towards an increased risk of gestational hypertensive disorders at 25(OH)D concentrations <50 nmol/L, caution should be exercised with dosing in trials, given the lack of data on long-term safety. The possibility that a fairly narrow target range for circulating 25(OH)D for achievement of clinically-relevant improvements requires further exploration. As hypertension alone, and not preeclampsia specifically, limits intrauterine growth, evaluation of the relationship between vitamin D status and all terms of hypertension in pregnancy is a clinically relevant area for research and should be prioritised in future randomised trials.

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“…A retrospective fully blinded cohort study of 257 pregnant women in an obstetric emergency service in Spain also found no association between SFlt-1/PIGF and 25(OH)D levels in women with PE. However, this study found a greater risk of late-onset PE among women with low 25(OH)D level (<50 nmol/L) (OR 4.6, 95% CI 1.4–15) and increased risk of both early- and late-onset PE when sFlt-1/PIGF ratios were above corresponding cut-points (ORs 58 [95% CI 11–312] and 12 [95% CI 5.0–27], respectively) [90]. …”

Section: Resultsmentioning

confidence: 99%

“…Studies reported varying degrees of risk for clinical subtypes of PE among women with low vitamin D levels [79, 90]. In order to guide the clinical recommendations, investigators must use a standard set of definitions for the disease and clinical subtypes in future research.…”

Section: Discussionmentioning

confidence: 99%

The role of vitamin D in pre-eclampsia: a systematic review

Purswani

Gala

Dwarkanath

et al. 2017

BMC Pregnancy Childbirth

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BackgroundThe etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D is known to have anti-inflammatory properties and there is evidence of an inverse relationship between dietary calcium intake and the incidence of PE. Evidence of the role of vitamin D status and supplementation in the etiology and prevention of PE is reviewed in this article along with identification of research gaps to inform future studies.MethodsWe conducted a structured literature search using MEDLINE electronic databases to identify published studies until February 2015. These sources were retrieved, collected, indexed, and assessed for availability of pregnancy-related data on PE and vitamin D.ResultsSeveral case-control studies and cross-sectional studies have shown an association between vitamin D status and PE, although evidence has been inconsistent. Clinical trials to date have been unable to show an independent effect of vitamin D supplementation in preventing PE.ConclusionsThe included clinical trials do not show an independent effect of vitamin D supplementation in preventing PE; however, issues with dose, timing, and duration of supplementation have not been completely addressed.Electronic supplementary materialThe online version of this article (doi:10.1186/s12884-017-1408-3) contains supplementary material, which is available to authorized users.

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Role of vitamin D and sFlt-1/PlGF ratio in the development of early- and late-onset preeclampsia

Abstract: Low vitamin D status in women with suspected late-onset PE increases the risk of imminent development of the disease.

Cited by 15 publications

References 13 publications

Maternal and neonatal vitamin D status at birth in black South Africans

Maternal and neonatal vitamin D status at birth in black South Africans

Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy

The role of vitamin D in pre-eclampsia: a systematic review

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