Role of vitamin C on lead acetate induced spermatogenesis in swiss mice

Acharya, Usha; Rathore, Raja Mansingh; Mishra, Monalisa

doi:10.1016/s1382-6689(02)00107-2

Cited by 41 publications

(16 citation statements)

References 40 publications

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“…It is well-known that ROS could cause chromosomal aberrations by mutating certain gene segments, resulting in abnormal sperm population and/or dramatically reduce in sperm count (Eyden et al, 1978;Hartwing et al, 1990;Hsu et al, 1998). For instance, chromosomal aberrations, increased sperm abnormalities and decreased sperm count profile in lead-exposed mice (Usha et al, 2003).…”

Section: Leadmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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Section: Leadmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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“…artichoke extract, daily for 6 weeks by stomach tube. The fourth group, vitamin C-protected group as a positive herbal antioxidant group (Acharya et al, 2003;Vij et al, 1998) received 500 mg lead acetate/kg diet and 1 mg vitamin C/100 g b.w., daily for 6 weeks by stomach tube (Shalan et al, 2005). At the end of the experimental period, fasted animals were anesthetized with chloroform and their blood samples were collected in test tubes.…”

Section: Experimental Designmentioning

confidence: 99%

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Heidarian

Rafieian-Kopaei

2013

Pharmaceutical Biology

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Context: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it has antitoxic activity. Objective: Lead (Pb) is a dangerous environmental toxicant that induces a broad range of dysfunctions in human. This study evaluated the protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with lead-containing diet. Materials and methods: Thirty-two rats were randomly divided into four groups. The first (control) group received standard diet. The second, third and fourth groups received 500 mg lead/kg diet, 500 mg lead/kg diet plus 300 mg/kg b.w. artichoke extract daily, and 500 mg lead/ kg diet plus 1 mg vitamin C/100 g b.w. daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), malondialdehyde (MDA) and liver histopathology assessments were conducted. Results: Serum lead, triglyceride (TG), VLDL, ALT, AST, ALP and MDA levels decreased significantly (p50.05) in the artichoke-treated group (35.85, 38.26, 38.38, 21.90, 12.81, 26.86 and 46.91%, respectively) compared to lead-intoxicated rats without treatment. No significant change was observed in serum lead, ALP and ALT between artichoke and vitamin C-treated groups (p40.05). Furthermore, the liver histopathology in rats treated with artichoke showed a mild degree of lymphocyte infiltration that was relatively comparable to the control and vitamin C-treated groups. Discussion and conclusion: These results clearly show that the artichoke extract in lead-poisoned rats has suitable chelating properties for the reduction of blood lead levels.

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“…Lead has been one of the most important heavy metals because of its common usage in various industrial products, and therefore, is considered as a serious occupational hazard throughout the world (Ahmed et al 2012). It is well known that testes are very sensitive to oxidative stress due to its higher polyunsaturated fatty acid content (Acharya et al 2003). It has been show that lead exposure enhances intracellular ROS production and lipid peroxidation, including tissue damage in animal reproductive systems (Wang and Jia 2009).…”

Section: Introductionmentioning

confidence: 99%

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

Apaydın

Kalender

Baş

et al. 2014

Braz. arch. biol. technol.

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Role of vitamin C on lead acetate induced spermatogenesis in swiss mice

Cited by 41 publications

References 40 publications

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite

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