Role of Vitamin B-12 in chronic low backache: A comparative study

Abstract

Background: Chronic low backache is a commonly affecting problem in our population; it has an economic impact due to the consumption of health expenses in its treatment and rehabilitation. Backache interferes with daily activities of life without discriminating age, gender or race, etc. Our study aimed to determine the role of vitamin B-12 in relieving chronic low backache.
 Methodology: A comparative study was conducted at Baqai University and Fatima Hospital, Karachi, from May 2019 to April 2020. A total of 496 patients were enrolled and divided into two groups; group I was treated with vitamin B-12 (n=256), and group II (n=240) did not receive vitamin B-12 treatment. Pre-treatment Visual Analog Scale (VAS) score and Oswestry Disability Index (ODI) scores were evaluated. Group II was given calcium supplements and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for one month, while group I was given intramuscular injections of vitamin B-12 (500 mcg) on an alternate day for a month along with calcium supplements and NSAIDs.
 Results: Pre-treatment mean VAS and ODI scores were 6.68 ± 1.45 and 30.11 ± 12.7, while post-treatment VAS and ODI scores were subsequently 3.50 ± 2.07 and 17.73 ± 12.7, respectively. At the end of treatment, a remarkable decrease in ODI and VAS scores was observed after treatment with vitamin B-12 (p<0.05).
 Conclusion: Concurrent use of vitamin B-12 in the treatment of chronic backache had a better impact in relieving backache symptoms than those treated without vitamin B-12.

Knowledge of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and their Adverse Effects among Medical and Non-Medical Students

“…NSAIDs are usually considered comparatively safe medications by the community as they are readily available over the counter without any prescriptions, which might have contributed to the increased consumption of NSAIDs in the past few years 9,10 . However, they have the most frequent and severe side effects related to GIT, about which prior studies suggest that people using over-the-counter (OTC) analgesics do not have sufficient awareness and appropriate health literacy about these drastic effects, which can lead to severe complications due to their lack of knowledge about NSAIDs people usually do not consult their physicians before using them 11,12 .…”