Role of vitamin A in health and illness

Marzęda, Paweł; Łuszczki, Jarogniew J.

doi:10.26444/jpccr/112376

Cited by 9 publications

(11 citation statements)

References 71 publications

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“…We can find them in sweet potatoes, carrots, melons, peppers, apricots, nectarines, tomatoes, mangoes and corn. They are also present in spinach, peas, parsley, pistachios, kale, broccoli and Swiss chard, where green chlorophyll masks the carotenoid pigment [1,10].…”

Section: Food Sources Of Vitamin Amentioning

confidence: 99%

“…Their concentrations reflect vitamin A status and provide us with an insight into its metabolism, homeostasis and help us to overcome pathological conditions associated with altered vitamin A metabolism [1]. Excess (hypervitaminosis) or deficiency (hypovitaminosis) of vitamin A can both be harmful [1,10,12].…”

Section: Food Sources Of Vitamin Amentioning

confidence: 99%

“…The disease can be acute if very high doses are ingested in a short time, or chronic, if the ingestion of excessive doses occurs over a longer period. In the acute form, the symptoms appear a few hours after the intake, and may include dizziness, disturbances of consciousness, irritability, nose bleeding, headache, nausea, vomiting, and abdominal pain [9,10,13]. Early signs of chronic hypervitaminosis include thinning of hair and eyebrows, cracked lips, and dry and rough skin.…”

Section: Hypervitaminosis Amentioning

confidence: 99%

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The Role of Vitamin A in Retinal Diseases

Sajovic

Meglič

Glavač

et al. 2022

IJMS

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Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. This review provides a comprehensive overview of diseases that are directly or indirectly connected with vitamin A pathways in the retina. It includes the pathophysiological background and clinical presentation of each disease and summarizes the already existing therapeutic and prospective interventions.

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Section: Food Sources Of Vitamin Amentioning

confidence: 99%

Section: Food Sources Of Vitamin Amentioning

confidence: 99%

Section: Hypervitaminosis Amentioning

confidence: 99%

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The Role of Vitamin A in Retinal Diseases

Sajovic

Meglič

Glavač

et al. 2022

IJMS

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“…Vitamin A is obtained once β-carotene breaks down symmetrically, so each carotene molecule gives rise to two vitamin A molecules. Vitamin A is important in the regulation of redox homeostasis in diverse physiological events related to vision, growth and development, among others [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO)

Guevara

Domínguez-Anaya

Ortigosa

et al. 2021

IJMS

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Plant species are precursors of a wide variety of secondary metabolites that, besides being useful for themselves, can also be used by humans for their consumption and economic benefit. Pepper (Capsicum annuum L.) fruit is not only a common food and spice source, it also stands out for containing high amounts of antioxidants (such as vitamins C and A), polyphenols and capsaicinoids. Particular attention has been paid to capsaicin, whose anti-inflammatory, antiproliferative and analgesic activities have been reported in the literature. Due to the potential interest in pepper metabolites for human use, in this project, we carried out an investigation to identify new bioactive compounds of this crop. To achieve this, we applied a metabolomic approach, using an HPLC (high-performance liquid chromatography) separative technique coupled to metabolite identification by high resolution mass spectrometry (HRMS). After chromatographic analysis and data processing against metabolic databases, 12 differential bioactive compounds were identified in sweet pepper fruits, including quercetin and its derivatives, L-tryptophan, phytosphingosin, FAD, gingerglycolipid A, tetrahydropentoxylin, blumenol C glucoside, colnelenic acid and capsoside A. The abundance of these metabolites varied depending on the ripening stage of the fruits, either immature green or ripe red. We also studied the variation of these 12 metabolites upon treatment with exogenous nitric oxide (NO), a free radical gas involved in a good number of physiological processes in higher plants such as germination, growth, flowering, senescence, and fruit ripening, among others. Overall, it was found that the content of the analyzed metabolites depended on the ripening stage and on the presence of NO. The metabolic pattern followed by quercetin and its derivatives, as a consequence of the ripening stage and NO treatment, was also corroborated by transcriptomic analysis of genes involved in the synthesis of these compounds. This opens new research perspectives on the pepper fruit’s bioactive compounds with nutraceutical potentiality, where biotechnological strategies can be applied for optimizing the level of these beneficial compounds.

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“…Vitamin A is obtained once -carotene breaks down symmetrically, so each carotene molecule gives rise to two vitamin A molecules. Vitamin A is important in the regulation of redox homeostasis in diverse physiological events related to vision, growth and development, among others [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (<em>Capsicum annuum</em> L.) Fruits and Their Modulation by Nitric Oxide (NO)

Guevara¹,

Domínguez-Anaya²,

Ortigosa³

et al. 2021

Preprint

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Plant species are precursors of a wide variety of secondary metabolites that, besides having useful activity for themselves, can also be used by humans for their consumption and economic benefit. Pepper (Capsicum annuum L.) fruit is not only a common food and spice source, but it also stands out for containing high amounts of antioxidants (such as vitamins C and A), polyphenols and capsaicinoids. Particular attention has been paid to capsaicin, whose anti-inflammatory, antiproliferative and analgesic activities, have been proven. Due to the potential interest in pepper metabolites for human use, in this project, we carried out an investigation to identify new bioactive compounds of this crop is carried out. To achieve this, we developed a metabolomic approach, using an HPLC (high-performance liquid chromatography) separative technique coupled to metabolite identification by high resolution mass spectrometry (HRMS). After chromatographic analysis and data processing against metabolic databases, 12 differential bioactive compounds were identified in sweet pepper fruits, including quercetin and its derivatives, L-tryptophan, phytosphingosin, FAD, gingerglycolipid A, tetrahydropentoxylin, blumenol C glucoside, colnelenic acid and capsoside A. The abundance of these metabolites varied depending on the ripening stage of the fruits, either immature green or ripe red. We also studied the variation of these 12 metabolites upon treatment with exogenous nitric oxide (NO), a free radical gas involved in a good number of physiological processes in higher plants such as germination, growth, flowering, senescence, and fruit ripening, among others. Overall, it was found that the content of the analysed metabolites was modulated by the ripening stage and by the presence of NO. The metabolic pattern followed by quercetin and its derivatives, as a consequence of the ripening stage and NO treatment, was also corroborated by transcriptomic analysis of genes involved in the synthesis of these compounds. This opens new research windows on the pepper fruit’s bioactive compounds with nutraceutical potentiality, where biotechnological strategies can be applied for optimizing the level of these beneficial compounds.

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Role of vitamin A in health and illness

Cited by 9 publications

References 71 publications

The Role of Vitamin A in Retinal Diseases

The Role of Vitamin A in Retinal Diseases

Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO)

Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (<em>Capsicum annuum</em> L.) Fruits and Their Modulation by Nitric Oxide (NO)

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