Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohnʼs disease patients

Pousa, Inés D.; Maté, José; Salcedo-Mora, Xamila; Abreu, María T.; Moreno–Otero, Ricardo; Gisbert, Javier P.

doi:10.1002/ibd.20269

Cited by 37 publications

(29 citation statements)

References 27 publications

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“…53,67,72 These findings were supported by the data from human studies in CD. 73,74 Understanding the regulation and dysregulation of those angiogenic factors may provide insight to the pathogenesis and treatment of CD. Blood vessels and their endothelia play a crucial role in mucosal immune homeostasis through the tight regulation of leukocyte migration from the intravascular space to the interstitial space.…”

Section: Blood Vesselsmentioning

confidence: 99%

The Role of the Mesentery in Crohnʼs Disease

Zhu

Zuo

et al. 2016

Inflammatory Bowel Diseases

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Crohn's disease (CD) is a complex gastrointestinal disorder involving multiple levels of cross talk between the immunological, neural, vascular, and endocrine systems. The current dominant theory in CD is based on the unidirectional axis of dysbiosis-innate immunity-adaptive immunity-mesentery-body system. Emerging clinical evidence strongly suggests that the axis be bidirectional. The morphologic and/or functional abnormalities in the mesenteric structures likely contribute to the disease progression of CD, to a less extent the disease initiation. In addition to adipocytes, mesentery contains nerves, blood vessels, lymphatics, stromal cells, and fibroblasts. By the secretion of adipokines that have endocrine functions, the mesenteric fat tissue exerts its activity in immunomodulation mainly through response to afferent signals, neuropeptides, and functional cytokines. Mesenteric nerves are involved in the pathogenesis and prognosis of CD mainly through neuropeptides. In addition to angiogenesis observed in CD, lymphatic obstruction, remodeling, and impaired contraction maybe a cause and consequence of CD. Lymphangiogenesis and angiogenesis play a concomitant role in the progress of chronic intestinal inflammation. Finally, the interaction between neuropeptides, adipokines, and vascular and lymphatic endothelia leads to adipose tissue remodeling, which makes the mesentery an active participator, not a bystander, in the disease initiation and precipitation CD. The identification of the role of mesentery, including the structure and function of mesenteric nerves, vessels, lymphatics, and fat, in the intestinal inflammation in CD has important implications in understanding its pathogenesis and clinical management.

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Section: Blood Vesselsmentioning

confidence: 99%

The Role of the Mesentery in Crohnʼs Disease

Zhu

Zuo

et al. 2016

Inflammatory Bowel Diseases

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“…11 VEGF is elevated in the tissue and serum of patients with IBD. 12–14 In addition, soluble ICAM-1 is elevated in patients with IBD with active disease.…”

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confidence: 99%

Combined Serological, Genetic, and Inflammatory Markers Differentiate Non-IBD, Crohnʼs Disease, and Ulcerative Colitis Patients

Plevy¹,

Silverberg²,

Lockton³

et al. 2013

Inflammatory Bowel Diseases

114

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Background-Previous studies have demonstrated that serological markers can assist in diagnosing inflammatory bowel disease (IBD). In this study, we aim to build a diagnostic tool incorporating serological markers, genetic variants, and markers of inflammation into a computational algorithm to examine patterns of combinations of markers to (1) identify patients with IBD and (2) differentiate patients with Crohn's disease (CD) from ulcerative colitis (UC).

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“…In this preliminary study, and as previously described in patients with Crohn's disease [31], it appears that the molecules that favor the stability and maturation of vascular networks during developmental angiogenesis such a Ang1 were under-expressed in UC patients. On the contrary, destabilizing ligand Ang2 and the most critical regulator of the angiogenic process, VEGF, were up-regulated, at least at the level of circulating proteins.…”

Section: Discussionmentioning

confidence: 66%

“…Their concentrations were determined by the standard curve obtained when using the standards supplied with the kit and according to manufacturer instructions. Inter-and intra-assay precision was determined and calculated in-house as previously described [10,31].…”

Section: Determination Of Soluble Angiogenic Factorsmentioning

confidence: 99%

Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients

et al. 2010

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VEGF, Ang1, and Ang2 levels showed statistically significant differences between UC patients and healthy controls. Although determination of PlGF serum levels before corticosteroid treatment might be helpful to anticipate the response by UC patients, no angiogenic pattern that could accurately predict "a priori" this response to corticosteroid treatment was observed. Corticosteroids altered temporarily circulating levels of VEGF, angiopoietins and Tie2. No correlation was found between systemic levels of angiogenic factors and the clinical activity of UC.

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Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohnʼs disease patients

Abstract: In comparison with healthy controls, CD patients were found to have an active angiogenic profile, as detected by significant alterations in levels of angiogenesis soluble markers. These patients did not differ in serum levels of angiogenic factors according to phenotypic disease behavior.

Cited by 37 publications

References 27 publications

The Role of the Mesentery in Crohnʼs Disease

The Role of the Mesentery in Crohnʼs Disease

Combined Serological, Genetic, and Inflammatory Markers Differentiate Non-IBD, Crohnʼs Disease, and Ulcerative Colitis Patients

Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients

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