Role of Urodynamics in the Evaluation of Urinary Incontinence and Prolapse

Nager, Charles W.

doi:10.1007/s13669-013-0048-5

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…In 2011, FDA published a safety communication in response to concerns over surgical complications involving the use of transvaginal mesh for POP [ 10 ], and FDA ultimately banned the production and sale of these devices on April 16, 2019 [ 11 ]. Additionally, several countries (e.g., Australia and New Zealand) and companies have recently banned or paused the use of synthetic meshes [ 12 ]. Currently, these meshes are facing unprecedented challenges.…”

Section: Introductionmentioning

confidence: 99%

Development of a cellulose-based prosthetic mesh for pelvic organ prolapse treatment: In vivo long-term evaluation in an ewe vagina model

Lai

Zhang

Chen

et al. 2021

Materials Today Bio

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The use of vaginal surgical mesh to treat pelvic organ prolapse (POP) has been associated with high rates of mesh-related complications. In the present study, we prepared new kinds of meshes based on bacterial cellulose (BC) and collagen-coated BC (BCCOL) using a laser cutting method and perforation technique. The mechanical properties of pre-implanted BC meshes, including breaking strength, suture strength and rigidity, were equal to or exceeded those of available clinically used polypropylene meshes. An in vitro cellular assay revealed that BCCOL meshes exhibited enhanced biocompatibility by increasing collagen secretion and cell adhesion. Both BC and BCCOL meshes only caused weak inflammation and were surrounded by newly formed connective tissue composed of type I collagen after implantation in a rabbit subcutaneous model for one week, demonstrating that the novel mesh is fully biocompatible and can integrate into surrounding tissues. Furthermore, a long-term (ninety days) ewe vaginal implantation model was used to evaluate foreign body reactions and suitability of BC and BCCOL meshes as vaginal meshes. The results showed that the tissue surrounding the BC meshes returned to its original physiology as muscle tissue, indicating the excellent integration of BC meshes into the surrounding tissues without triggering severe local inflammatory response post-implantation. The collagen coating appeared to induce a chronic inflammatory response due to glutaraldehyde remnants. The present exploratory research demonstrated that the developed BC mesh might be a suitable candidate for treating POP.

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Section: Introductionmentioning

confidence: 99%

Development of a cellulose-based prosthetic mesh for pelvic organ prolapse treatment: In vivo long-term evaluation in an ewe vagina model

Lai

Zhang

Chen

et al. 2021

Materials Today Bio

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“…The only benefit of urodynamic study is when it changes clinical diagnosis and the final diagnosis based on UDS requires an entirely different line of treatment. 1 As a diagnostic test that also can provide prognostic information, urodynamics are requested when there is a specific question that needs to be answered. Urodynamic studies (UDS) are used to help in the diagnosis of storage or emptying problems (urinary incontinence, voiding dysfunction, obstruction, etc.).…”

Section: Introductionmentioning

confidence: 99%

Key Messages of Urodynamic Studies in Cases of Urinary Incontinence and Pelvic Organ Prolapse: A Retrospective Review

Chughtai¹,

Rizvi²,

Kashif³

2016

Journal of South Asian Federation of Obstetrics and Gynaecology

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Objectives: There is conflicting evidence regarding the indications of urodynamic studies (UDS) and various guidelines. American urogynecologic Society (AUGS), National Instititute of Health and Care Excellence (NICE), and WHO provide variant indications for UDS testing. For developing countries, there are no data to support the usefulness of UDS. Considering the cost, invasiveness, and expertise required for UDS, we planned to review UDS performed at Aga Khan University and Hospital (AKUH) from 2007 to 2014. Our purpose of study was to derive important conclusive messages as a guideline for future practices. Study design: This is a cross-sectional retrospective review of 500 patients undergoing UDS from 2007 to 2014. Results: Comparison between clinical diagnoses and urodynamic diagnoses was done and frequencies were computed. The mean age of the patients was 61.1 years, the mean body mass index was 25 and mean parity was 4.1. There was a matching between clinical and urodynamic findings of stress urinary incontinence (SUI) and overactive bladder (OAB), but disparity was observed in cases of mixed urinary incontinence (MUI) and lower urinary tract symptoms (LUTS). Occult SUI was found in 33% of patients with POP. Conclusion: Key messages were derived for future practice stating that for cases of SUI and OAB, UDS are not required, but patients with complex MUI, chronic LUTS, and neurogenic bladder warrant UDS.

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Concomitant Management of Occult and Symptomatic Stress Urinary Incontinence

Weissbart

Smith

2017

The Use of Robotic Technology in Female Pelvic Floor Reconstruction

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Role of Urodynamics in the Evaluation of Urinary Incontinence and Prolapse

Cited by 4 publications

References 39 publications

Development of a cellulose-based prosthetic mesh for pelvic organ prolapse treatment: In vivo long-term evaluation in an ewe vagina model

Development of a cellulose-based prosthetic mesh for pelvic organ prolapse treatment: In vivo long-term evaluation in an ewe vagina model

Key Messages of Urodynamic Studies in Cases of Urinary Incontinence and Pelvic Organ Prolapse: A Retrospective Review

Concomitant Management of Occult and Symptomatic Stress Urinary Incontinence

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