Role of Urinary Zinc and Copper on Calcium Oxalate Stone Formation

Özgürtaş, Taner; Yakut, Gurer; Güleç, Mahir; Serdar, Muhittin; Kutluay, Türker

doi:10.1159/000077122

Cited by 26 publications

(24 citation statements)

References 11 publications

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“…However the others, found significantly higher amounts of Cu in urinary excretion of stone patients [1,6,7]. Some studies showed that serum levels of Cu do not show any difference between stone patients and heathy controls [3,7,8]. In the present study, the mean urinary Cu levels in stone patients was 0.16 ± 0.5 ppm and was significantly higher than healthy controls.…”

Section: Discussioncontrasting

confidence: 53%

“…Meyer and Angino [5] observed the inhibitory effect of Cu on calcium phosphate stones but they also reported that Cu did not affect the crystal growth of calcium oxalate. Some authors detected no differences relating to Cu urinary excretion between stone patients and healthy controls [3,8,13,14]. However the others, found significantly higher amounts of Cu in urinary excretion of stone patients [1,6,7].…”

Section: Discussionmentioning

confidence: 96%

“…Meyer et Angino observed the inhibitory effect of Zn on calcium phosphate stones but not on calcium oxalate growth [5]. Some studies showed significantly higher amounts of Zn in urinary excretion of stone patients [1,[6][7][8][9][10][11][12]. Some authors detected no differences relating to Zn urinary excretion between healthy controls and stone patients [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors detected no differences relating to Zn urinary excretion between healthy controls and stone patients [13][14][15]. There have also been some studies showing that serum levels of Zn does not show any significant difference between healthy controls and stone patients [7,8]. In some studies, serum Zn is lower in stone patients than healthy controls [1,9,15].…”

Section: Discussionmentioning

confidence: 99%

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Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients

et al. 2007

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Many theories have been put forward to explain the mechanism of stone formation and growth. The aim of this study was to investigate the urinary, serum and stone levels of zinc, iron, magnesium, and copper in patients with calcium oxalate stones and to investigate urinary and serum element levels in healthy controls and to find a possible connection between the elements and calcium oxalate stone formation. A total of 104 patients with calcium oxalate stones ranging in age from 3 to 79 years (mean 44.0 +/- 18.1) and 77 healthy controls ranging in age from 18 to 77 (mean 44.2 +/- 17.9) were included in this study. The mean urinary iron and copper levels in stone patients were significantly higher than healthy controls (P = 0.000). The mean urinary zinc and magnesium levels in healthy controls were significantly higher than stone patients (P = 0.000). There was no significant difference in the serum levels of magnesium and copper in stone patients and healthy controls. Serum zinc and iron level were significantly high in healthy controls as compared to stone patients. Each stone had all 4 elements. Zn and Mg have inhibitory effect on calcium oxalate stone formation. Fe and Cu could be promotor of the calcium oxalate stone formation.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients

et al. 2007

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“…We made the hypothesis these groups of proteins are more important in the process of crystal formation based on previous published work. [20][21][22][23] We have previously looked into a different cohort of flies for the corresponding transcriptive changes (data not shown), but the candidate proteins cannot be correlated at the mRNA level.…”

Section: Discussionmentioning

confidence: 99%

Proteomic changes in response to crystal formation inDrosophilaMalpighian tubules

Chung

Konietzny

Charles

et al. 2016

Fly

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Kidney stone disease is a major health burden with a complex and poorly understood pathophysiology. Drosophila Malpighian tubules have been shown to resemble human renal tubules in their physiological function. Herein, we have used Drosophila as a model to study the proteomic response to crystal formation induced by dietary manipulation in Malpighian tubules. Wild-type male flies were reared in parallel groups on standard medium supplemented with lithogenic agents: control, Sodium Oxalate (NaOx) and Ethylene Glycol (EG). Malpighian tubules were dissected after 2 weeks to visualize crystals with polarized light microscopy. The parallel group was dissected for protein extraction. A new method of Gel Assisted Sample Preparation (GASP) was used for protein extraction. Differentially abundant proteins (p<0.05) were identified by label-free quantitative proteomic analysis in flies fed with NaOx and EG diet compared with control. Their molecular functions were further screened for transmembrane ion transporter, calcium or zinc ion binder. Among these, 11 candidate proteins were shortlisted in NaOx diet and 16 proteins in EG diet. We concluded that GASP is a proteomic sample preparation method that can be applied to individual Drosophila Malpighian tubules. Our results may further increase the understanding of the pathophysiology of human kidney stone disease.

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The role of zinc in urinary stone disease

Negri

2018

Int Urol Nephrol

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In recent years, the role of trace elements in lithogenesis has received steadily increasing attention. It is well documented that some trace elements can influence the morphology and speed of the crystallization process. Zinc has been found in significant amounts in calcium stones relative or organic stones (uric acid and cystine), probably substituting calcium in crystals because of their similarity in charge and size. High Zn levels are present in carbapatite of Randal's plaques suggesting that zinc could promote calcium phosphate deposition in the medullar interstitium. Large-scale epidemiological studies have found an association of increased dietary zinc intake with increased risk of nephrolithiasis in adults but not in adolescents. Most studies examining urinary zinc levels in adults have reported increased urinary Zn excretion in stone formers. In an experimental model of organic crystal formation produced by silencing xanthine dehydrogenase in Drosophila fly, maneuvers that reduce Zn excretion have shown to reduce crystal formation in the lumen of the Malpighian tubules. This is curious because this is not a model of calcium stone formation. Finally, zinc supplementation has been associated with increased admissions for urinary lithiasis in men, but no change in calcium stone formation in children. Perhaps, some of these contradicting findings can be explained in part by the in vitro effect of zinc on the type and amount of calcium phosphate formed: At low concentrations, Zn inhibited the crystal growth of dicalcium phosphate dihydrate, octacalcium phosphate, and apatite, and at higher concentrations, it promoted the formation of amorphous calcium phosphate. Thus, further studies are needed to see whether manipulation of Zn metabolism can inhibit calcium stone formation.

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Role of Urinary Zinc and Copper on Calcium Oxalate Stone Formation

Cited by 26 publications

References 11 publications

Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients

Serum, urinary and stone zinc, iron, magnesium and copper levels in idiopathic calcium oxalate stone patients

Proteomic changes in response to crystal formation inDrosophilaMalpighian tubules

The role of zinc in urinary stone disease

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