Role of Urinary Albumin in the Prediction of Preeclampsia

Fatema, Kaneez; Khatun, Mst. Afifa; Akter, Shirin; Ali, L

doi:10.3329/fmcj.v6i1.7404

Cited by 9 publications

(11 citation statements)

References 6 publications

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“…We found that the spot urinary ACR at 20-28 weeks of gestation was significantly higher in women who subsequently developed pre-eclampsia with mean value of 51.95 ± 18.78 mg/mmol and then in those who remain normotensive with mean value of 19.26 ± 7.99 mg/mmol. Baweja et al [9] and Fatema et al [11] found the similar results in their studies. The sensitivity of ACR at cut-off value of C35.5 mg/mmol as screening test to predict pre-eclampsia in our study was found to be 87.5% which is comparable to the studies done by Baweja et al [9] (83.3%) and Fatema et al [11] (80%).…”

Section: Discussionsupporting

confidence: 73%

Evaluation of Spot Urinary Albumin–Creatinine Ratio as Screening Tool in Prediction of Pre-eclampsia in Early Pregnancy

Mishra

Goyal

Roy

et al. 2016

J Obstet Gynecol India

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Section: Discussionsupporting

confidence: 73%

Evaluation of Spot Urinary Albumin–Creatinine Ratio as Screening Tool in Prediction of Pre-eclampsia in Early Pregnancy

Mishra

Goyal

Roy

et al. 2016

J Obstet Gynecol India

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“…11,12 The sensitivity of spot UPCR at the cut-off value of ≥ 35.5 mg/mmol as a screening test to predict preeclampsia in our study was found to be 80% which is comparable to the studies done by Baweja et al, (83.3%), Fatema et al, (80%) and Mishra et al, (87.5%). [11][12][13] In the present study abnormal uterine artery doppler indices (RI > .0.7/PI > 1.4/ presence of diastolic notch) were associated with increased risk of developing preeclampsia in later part of pregnancy. The cut-off value of RI and PI was similar with the study of Sahoo et al 14 Razieh DF et al, found that 23 pregnancies (85.2%) with preeclampsia had RI more than 0.7 and only 4 (14.8%) had RI < 0.7 (p = 0.001).…”

Section: Discussionsupporting

confidence: 86%

Prediction of preeclampsia by a combination of maternal spot urinary protein-creatinine ratio and uterine artery doppler

Modak¹,

Pal²,

Pal³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia (PE) is heterogeneous disorder. The aim of the study was to observe the role of a spot urinary protein - creatinine ratio (UPCR) and uterine artery doppler velocimetry measured between 20-24 weeks of gestation in prediction of preeclampsia.Methods: Prospective observational study conducted on 120 pregnant mothers with singleton pregnancy between 20-24 weeks of gestational age in two tertiary teaching hospitals in eastern India. A spot urinary protein creatinine ratio (UPCR) was determined in a mid- stream urine sample and estimation of protein was done by immunoturbidimetric micro albumin method and creatinine by modified Jaffe’s method. Doppler velocimetry was also determined at 20-24 weeks of gestation. A notch in uterine artery, unilateral or bilateral; or RI > 0.7 and PI of > 1.45 were considered to have an abnormal result. Women were followed-up and relationship between variables was assessed by Chi- square test.Results: Women who subsequently developed preeclampsia had significantly higher UPCR (median 44.8 mg/mmol) when compared with women of unaffected groups (median 26.6 mg/mmol). The optimum spot urinary UPCR to predict preeclampsia was 35.5 mg/mmol and the cut-off value >35.5 mg/mmol had a test sensitivity (80%), specificity (94.06%), PPV (66.76%) and NPV (96.94%).The area under curve (AUC) of spot UPCR in ROC curve was 0.949 (95% CI,0.891 - 1.000). For predicting preeclampsia, the mean uterine artery RI had to be >0.7 having sensitivity (60%), specificity (97.03%), PPV (75%) and NPV (94.23%). The area under curve (AUC) was 0.856 (95% CI, 0.742 - 0.971).Conclusions: Second trimester UA doppler is a useful screening test for prediction of preeclampsia. This test works best when combined with a spot UPCR and accuracy of both the methods for prediction of preeclampsia was 92.24%.

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“…They concluded that the test was sufficient enough to predict the possibility of pre-eclampsia. Although their inference was comparable with the ones presented by Baweja S. et al 15 (83.3% sensitivity) and Fatema K et al 16 (80% sensitivity), but the study consisted of a very small sample size.…”

Section: Discussionsupporting

confidence: 85%

Urinary Albumin to Creatinine Ratio as a Predictor of Preclampsia Among Pregnant Women at a Tertiary Care Hospital

2019

JMPB

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Objective:To determine the diagnostic accuracy of point urinary albumin to creatinine ratio at 20 +0 and 28 +0 weeks of gestation for predicting the possibility of developing pre-eclampsia, late in pregnancy. Study Design:A prospective cross sectional study. Place and Duration of Study: Gynecology Outpatients DepartmentMethodology: Age, weight, gravidity and Body Mass index was documented for total 250 patients included for study. Patients were divided on the basis of development of pre-eclampsia and their mean Albumin to creatinine ratio was compared by applying Student's t-test considering p≤0.05 statistically significant. Test positive and test negative patients were noted. The association of urinary albumin to creatinine ratio with pre-eclampsia was calculated. SPSS v.23 software was used to analyze the data. Results:Mean urinary albumin to creatinine ratio was 22.77±12.42 mg/mmol in normotensive women and 46.87±15.13 mg/mmol in pre-eclamptic women which was significantly higher in pre-eclamptic patients (p<0.001). The sensitivity of point urinary albumin to creatinine ratio at a cutoff value of 35.5mg/mmol is 73.91%; the specificity is 91.56%; the positive predictive value (PPV) is 72.34%; and negative predictive is 92.16%. Conclusion:Our study concluded that solitary point urinary albumin creatinine ratio values equal to or higher than 35.5mg/mmol, when quantified early during the second trimester had a higher specificity than the sensitivity and it can be safely used to rule out the possibility of developing pre-eclampsia, late in pregnancy.

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Role of Urinary Albumin in the Prediction of Preeclampsia

Cited by 9 publications

References 6 publications

Evaluation of Spot Urinary Albumin–Creatinine Ratio as Screening Tool in Prediction of Pre-eclampsia in Early Pregnancy

Evaluation of Spot Urinary Albumin–Creatinine Ratio as Screening Tool in Prediction of Pre-eclampsia in Early Pregnancy

Prediction of preeclampsia by a combination of maternal spot urinary protein-creatinine ratio and uterine artery doppler

Urinary Albumin to Creatinine Ratio as a Predictor of Preclampsia Among Pregnant Women at a Tertiary Care Hospital

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