Role of Upper Gastrointestinal Surveillance in Patients with Familial Adenomatous Polyposis

Sawada, Toshio; Muto, Tetsuichiro

doi:10.1016/s1052-5157(18)30326-x

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…They are most often confined to the antrum but are occasionally found in the body and fundus. (163,164) The lifetime risk for gastric cancer in FAP is ~0.6%, believed both from fundic gland polyps and adenomatous polyps (138). …”

Section: Lynch Syndrome (Ls)mentioning

confidence: 99%

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Syngal

Brand

Church

et al. 2015

American Journal of Gastroenterology

1,322

1,426

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This guideline presents recommendations for the management of patients with hereditary gastrointestinal cancer syndromes. The initial assessment is the collection of a family history of cancers and premalignant gastrointestinal conditions and should provide enough information to develop a preliminary determination of the risk of a familial predisposition to cancer. Age at diagnosis and lineage (maternal and/or paternal) should be documented for all diagnoses, especially in first- and second-degree relatives. When indicated, genetic testing for a germline mutation should be done on the most informative candidate(s) identified through the family history evaluation and/or tumor analysis to confirm a diagnosis and allow for predictive testing of at-risk relatives. Genetic testing should be conducted in the context of pre- and post-test genetic counseling to ensure the patient's informed decision making. Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers. This guideline specifically discusses genetic testing and management of Lynch syndrome, familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, serrated (hyperplastic) polyposis syndrome, hereditary pancreatic cancer, and hereditary gastric cancer.

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Section: Lynch Syndrome (Ls)mentioning

confidence: 99%

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Syngal

Brand

Church

et al. 2015

American Journal of Gastroenterology

1,322

1,426

View full text Add to dashboard Cite

show abstract

“…7 The majority of FAP patients will have small (<2 mm) polyps and a tendency for slow disease progression with most not progressing to more advanced stages. 5,8,9 Surveillance of the upper gastrointestinal tract to prevent the development of duodenal cancer has been recommended by most authorities. Guidelines for the frequency of surveillance and management of duodenal lesions are not uniform and clinical outcome has been disappointing in some series, which have reported risk of progression to duodenal cancer in the range of 22% to 36% in patients with advanced duodenal polyposis.…”

mentioning

confidence: 99%

Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis

et al. 2015

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“…Gastric, fundic gland polyps occur in 23 to 100 percent of FAP patients. [5][6][7][8] Fundic gland polyps rarely progress to cancer. [9][10][11] Similar polyps, although fewer in number, are sometimes observed in the general population and possibly associated with chronic use of proton pump inhibitors.…”

Section: Cancer Risk In Fapmentioning

confidence: 99%

“…They are most often confined to the antrum but are occasionally found in the body and fundus. 6,14 Endoscopically visible duodenal adenomas are found in 50 to > 90 percent of FAP patients and microadenomas are frequently observed. 8 Adenomas also may occur throughout the small bowel but are concentrated for the most part in the proximal jejunum (50 percent of cases) and distal ileum (20 percent of cases).…”

Section: Cancer Risk In Fapmentioning

confidence: 99%

An Evidence-Based, Multidisciplinary Approach to the Clinical Considerations, Management, and Surveillance of Adrenal Lesions in Familial Adenomatous Polyposis: Report of Three Cases

Ferrández¹,

Pho²,

Solomon³

et al. 2006

Diseases of the Colon &Amp; Rectum

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Adrenal masses are commonly discovered incidentally in patients with familial adenomatous polyposis, and adrenal malignancies have been rarely reported. Individuals with familial adenomatous polyposis frequently undergo abdominal CT-scan examinations for surveillance or symptoms. Adrenal lesions often are detected unexpectedly and are thus becoming a common clinical problem in this population. Adrenal lesions encompass a heterogeneous spectrum of pathologic entities, including primary adrenocortical and medullary tumors, benign or malignant lesions, hormonally active or inactive lesions, metastases, and infections. When an adrenal mass is detected, the clinician needs to address two crucial questions: 1) is the mass malignant? and 2) is it hormonally active? This article presents three new cases of incidental adrenal lesions in familial adenomatous polyposis, reviews the medical literature for this setting, and provides an overview of the diagnostic clinical approach and management of the adrenal findings in familial adenomatous polyposis patients.

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Role of Upper Gastrointestinal Surveillance in Patients with Familial Adenomatous Polyposis

Cited by 10 publications

References 36 publications

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis

An Evidence-Based, Multidisciplinary Approach to the Clinical Considerations, Management, and Surveillance of Adrenal Lesions in Familial Adenomatous Polyposis: Report of Three Cases

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