Role of Up-Regulated Transmembrane Channel-Like Protein 5 in Pancreatic Adenocarcinoma

Gan, Xiang-Yu; Li, Jian‐Di; Chen, Gang; He, Rong‐Quan; Luo, Jia‐Yuan; Zeng, Jingjing; Yang, Zixuan; Ying, Yang; Zhu, Jun; Li, Jianjun; Wei, Dan‐Ming

doi:10.1007/s10620-022-07771-7

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…TMC5 is predicted to be involved in ion transmembrane transport, although its exact functions are still unclear. Previous studies have shown that TMC5 plays a role in the proliferation of prostate cancer and contributes to the poor prognosis of pancreatic adenocarcinoma [40] . However, the molecular mechanism of TMC5 in regulating malignant tumors is still unknown.…”

Section: Discussionmentioning

confidence: 99%

The landscape of Hepatocellular Carcinoma and Tumor-associated Telocytes Integrated Single-nucleus RNA Sequence and Transcriptomics Technology

Xu,

Li,

Zhang

et al. 2023

Preprint

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Background: Hepatocellular carcinoma (HCC) is the main malignant tumor in humans, known for its high metastasis and lethality. However, the molecular mechanisms underlying tumorigenesis in HCC are still unclear. Methods: To address this, we conducted a comprehensive analysis using single nucleus RNA sequencing (snRNA-seq) assay and transcriptomic technology. This approach allowed us to uncover genetic changes in cancer cells and other cells within the tumor microenvironment, leading to the identification of potential hub genes for HCC. Results: Our study analyzed snRNA-seq and transcriptomics data, revealing novel differentially expressed genes (DEGs) in HCC and identifying characteristic biomarkers for telocytes (TCs) through bioinformatics analysis. Notably, STAB2, OIT3, BMPER, MARCO, CRHBP, and FCN2 showed high specificity and sensitivity in predicting the prognosis or development of HCC. Conclusion: TMC5 and TRABD2B were identified as unique biomarkers for TCs in the liver. These DEGs warrant further investigation to validate their potential implications in HCC.

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Section: Discussionmentioning

confidence: 99%

The landscape of Hepatocellular Carcinoma and Tumor-associated Telocytes Integrated Single-nucleus RNA Sequence and Transcriptomics Technology

Xu,

Li,

Zhang

et al. 2023

Preprint

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“…In mammals, the transmembrane channel-like (TMC) family comprises eight members, TMC1–TMC8 ( Yue et al, 2019 ), with approximately ten transmembrane domains and a conserved TMC domain. Members of the TMC family are reportedly associated with several diseases; for instance, TMC8 is a potential biomarker for hepatocellular carcinoma ( Lu et al, 2017 ); TMC5 promotes prostate cancer cell proliferation ( Zhang et al, 2019 ) and is upregulated in pancreatic adenocarcinoma ( Gan et al, 2023 ); and TMC1/TMC2 localising in mouse inner ear hair bundles and converting the mechanical signals of sound into electrical signals, is related to deafness ( Jia et al, 2020 ). Previous studies have reported that TMC is associated with proprioception ( Guo et al, 2016 ; He et al, 2019 ) and texture discrimination in Drosophila sensory systems ( Wu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels

An,

Hu,

Hao

et al. 2024

Front. Pharmacol.

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Introduction: The transmembrane channel-like (TMC) protein family contains eight members, TMC1–TMC8. Among these members, only TMC1 and TMC2 have been intensively studied. They are expressed in cochlear hair cells and are crucial for auditory sensations. TMC6 and TMC8 contribute to epidermodysplasia verruciformis, and predispose individuals to human papilloma virus. However, the impact of TMC on peripheral sensation pain has not been previously investigated.Methods: RNAscope was employed to detect the distribution of TMC6 mRNA in DRG neurons. Electrophysiological recordings were conducted to investigate the effects of TMC6 on neuronal characteristics and M channel activity. Zn2+ indicators were utilized to detect the zinc concentration in DRG tissues and dissociated neurons. A series of behavioural tests were performed to assess thermal and mechanical sensation in mice under both physiological and pathological conditions.Results and Discussion: We demonstrated that TMC6 is mainly expressed in small and medium dorsal root ganglion (DRG) neurons and is involved in peripheral heat nociception. Deletion of TMC6 in DRG neurons hyperpolarizes the resting membrane potential and inhibits neuronal excitability. Additionally, the function of the M channel is enhanced in TMC6 deletion DRG neurons owing to the increased quantity of free zinc in neurons. Indeed, heat and mechanical hyperalgesia in chronic pain are alleviated in TMC6 knockout mice, particularly in the case of heat hyperalgesia. This suggests that TMC6 in the small and medium DRG neurons may be a potential target for chronic pain treatment.

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CellCommuNet: an atlas of cell–cell communication networks from single-cell RNA sequencing of human and mouse tissues in normal and disease states

Ma,

Li,

Zheng

et al. 2023

Nucleic Acids Research

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Cell−cell communication, as a basic feature of multicellular organisms, is crucial for maintaining the biological functions and microenvironmental homeostasis of cells, organs, and whole organisms. Alterations in cell−cell communication contribute to many diseases, including cancers. Single-cell RNA sequencing (scRNA-seq) provides a powerful method for studying cell−cell communication by enabling the analysis of ligand−receptor interactions. Here, we introduce CellCommuNet (http://www.inbirg.com/cellcommunet/), a comprehensive data resource for exploring cell−cell communication networks in scRNA-seq data from human and mouse tissues in normal and disease states. CellCommuNet currently includes 376 single datasets from multiple sources, and 118 comparison datasets between disease and normal samples originating from the same study. CellCommuNet provides information on the strength of communication between cells and related signalling pathways and facilitates the exploration of differences in cell−cell communication between healthy and disease states. Users can also search for specific signalling pathways, ligand−receptor pairs, and cell types of interest. CellCommuNet provides interactive graphics illustrating cell−cell communication in different states, enabling differential analysis of communication strength between disease and control samples. This comprehensive database aims to be a valuable resource for biologists studying cell−cell communication networks.

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Role of Up-Regulated Transmembrane Channel-Like Protein 5 in Pancreatic Adenocarcinoma

Cited by 3 publications

References 57 publications

The landscape of Hepatocellular Carcinoma and Tumor-associated Telocytes Integrated Single-nucleus RNA Sequence and Transcriptomics Technology

The landscape of Hepatocellular Carcinoma and Tumor-associated Telocytes Integrated Single-nucleus RNA Sequence and Transcriptomics Technology

The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels

CellCommuNet: an atlas of cell–cell communication networks from single-cell RNA sequencing of human and mouse tissues in normal and disease states

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