Role of Ultrasound Elastography in Prediction of Malignancy in Thyroid Nodules

Mansor, Mona; Okasha, Hussein Hassan; Esmat, Serag; Hashem, Ahmed M.; Attia, Khaled Ahmed; Hussein, Hossam El-din

doi:10.3109/07435800.2011.633952

Cited by 21 publications

(20 citation statements)

References 12 publications

(19 reference statements)

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“…Qualitative elastography has been described as a promising new technique in differentiating benign from malignant thyroid nodules [30][31][32][33][34][35][36][37][38][39][40][41][42]. The aim of this systematic review and metaanalysis was to investigate the diagnostic value of qualitative elastography in distinguishing benign from malignant thyroid nodules in patients referred for FNA and, thereby, potentially prevent unnecessary invasive diagnostic procedures.…”

Section: Discussionmentioning

confidence: 99%

Qualitative elastography can replace thyroid nodule fine-needle aspiration in patients with soft thyroid nodules. A systematic review and meta-analysis

Nell

Kist

Debray³

et al. 2015

European Journal of Radiology

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Section: Discussionmentioning

confidence: 99%

Qualitative elastography can replace thyroid nodule fine-needle aspiration in patients with soft thyroid nodules. A systematic review and meta-analysis

Nell

Kist

Debray³

et al. 2015

European Journal of Radiology

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“…There are a number of scientific reports about the diagnostic value of elastography in the differentiation of thyroid nodules in adults; however, there are no studies on the applications of elastography in the diagnosis of thyroid gland in children [19,20,21,22]. …”

Section: Discussionmentioning

confidence: 99%

Practical Application of Elastography in the Diagnosis of Thyroid Nodules in Children and Adolescents

et al. 2016

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Background: Ultrasound elastography is a noninvasive method of imaging based on the estimation of the mechanical properties of tissue. Data in adults indicate that decreased flexibility in comparison to the surrounding healthy tissue is characteristic of malignancy (in most thyroid carcinomas, except for follicular thyroid carcinoma). The purpose of our study was to assess the deformation of thyroid nodules and to evaluate the usefulness of elastography in predicting malignant thyroid nodules in adolescent patients. Methods: We examined 47 children with 62 thyroid nodules. All patients underwent elastography and fine needle aspiration cytology (FNAC). Results: Thirty-seven girls (79%) and 10 boys (21%) were included in the study. A strain ratio <2 was observed in 17 nodules (27% of the study group), a strain ratio between 2 and 4.9 in 34 nodules (55%) and a strain ratio >5 in 11 nodules (18%). According to cytological examination, 3 nodules (4.8% of the study group) were malignant. Two of them were hard (strain ratio ≥5), and 1 nodule had a strain ratio of 2. Conclusions: Our results suggest that elastography can be complementary to conventional ultrasonography and useful while making a decision about FNAC. At the same time, it should not replace the cytological assessment of thyroid nodules in children and adolescents.

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“…A meta-analysis of 8 RTE studies performed between 2005 and 2009 (639 thyroid nodules, 24% malignancies) calculated a pooled sensitivity and specificity of 92% and 90%, respectively [ 16 , 25 , 27 , 30 , 35 , 42 , 44 , 48 , 59 ] . Many reports suggest that RTE is an independent predictor for malignancy, with accuracy results exceeding conventional US criteria [ 17 , 23 , 31 , 33 , 36 , 39 , 46 , 47 , 49 , 54 , 55 ] . For example, Cantisani et al [ 23 ] documented much higher SRs in malignant compared with benign nodules (7.3 ± 4.3 vs. 1.2 ± 0.7), and an SR cut-off ≥2 achieved 97.3% sensitivity, 91.7% specificity, 87.8% positive predictive value (PPV), 98.2% negative predictive value (NPV) and 93.8% accuracy.…”

Section: Use For Evaluation Of Thyroid Nodulesmentioning

confidence: 99%

Ultrasound elastography in the head and neck. Part II. Accuracy for malignancy

Bhatia¹,

Lee²,

Yuen³

et al. 2013

Cancer Imaging

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Ultrasound elastography (USE) describes a variety of ultrasound-based imaging techniques that measure tissue stiffness properties, and is currently under intense investigation for tissue characterization in several anatomic sites. This article summarizes the evidence regarding the accuracy of USE for malignancy in the head and neck. Currently, most published data pertains to small pilot studies with varied methodologies. Encouragingly, most studies have documented promising results for USE in terms of high accuracy for malignancy in thyroid nodules and cervical lymph nodes, which have surpassed conventional sonographic criteria. However, a minority of studies have documented opposite findings. USE seems to be suboptimal for salivary malignancies, and some evidence suggests that USE does not provide useful diagnostic information compared with conventional ultrasonography for miscellaneous neck masses. Further larger studies are required to validate these findings although, in view of the predominance of highly optimistic results for thyroid nodules and cervical lymph nodes, USE may become a useful ancillary technique in the routine diagnostic work-up of lesions in these tissues in the near future.

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Role of Ultrasound Elastography in Prediction of Malignancy in Thyroid Nodules

Abstract: US elastography can be used to increase both the sensitivity and the specificity of US for the detection of malignant thyroid nodules, and so it seems to have great potential as a new tool for the diagnosis of thyroid cancer.

Cited by 21 publications

References 12 publications

Qualitative elastography can replace thyroid nodule fine-needle aspiration in patients with soft thyroid nodules. A systematic review and meta-analysis

Qualitative elastography can replace thyroid nodule fine-needle aspiration in patients with soft thyroid nodules. A systematic review and meta-analysis

Practical Application of Elastography in the Diagnosis of Thyroid Nodules in Children and Adolescents

Ultrasound elastography in the head and neck. Part II. Accuracy for malignancy

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