Role of Type I Interferons in the Pathogenesis of Bluetongue Virus in Mice and Ruminants

Saminathan, Mani; Singh, Kulwant; Rajasekar, Ramanujam; Malik, Y. P. S.; Dhama, Kuldeep

doi:10.18006/2019.7(6).513.520

Cited by 6 publications

(28 citation statements)

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“… 2014 ; Saminathan et al. 2019 ). Pattern recognition receptors (PRRs; located in the subcellular compartments, namely, endosomal and cytoplasmic) of the host recognizes the pathogen-associated molecular patterns (PAMPs) of pathogen (BTV dsRNA).…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2019 ), resulted in activation of different signalling [Janus kinase (JAK)/signal transducer and activator of transcription (STAT)] pathways leading to the production of type I and type III IFNs, and other pro-inflammatory cytokines (Ortego et al. 2014 ; Vitour et al.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2018 , 2019 ). Although, more than 40 years ago, induction of IFN-Is by BTV infection was reported, the mechanism of IFN-Is induction has remained unknown for several years.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2018 , 2019 ). The IFN-α/β was detected in the serum of sheep at 2 and 6 dpi inoculated with BTV-8.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2019 ). Infection of IFNAR (−/−) mice with BTV strongly induces the production of IFN-α/β.…”

Section: Mouse Models To Study Btv Infectionmentioning

confidence: 99%

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An updated review on bluetongue virus: epidemiology, pathobiology, and advances in diagnosis and control with special reference to India

Saminathan

Singh

Khorajiya

et al. 2020

Veterinary Quarterly

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Bluetongue (BT) is an economically important, non-contagious viral disease of domestic and wild ruminants. BT is caused by BT virus (BTV) and it belongs to the genus Orbivirus and family Reoviridae. BTV is transmitted by Culicoides midges and causes clinical disease in sheep, white-tailed deer, pronghorn antelope, bighorn sheep, and subclinical manifestation in cattle, goats and camelids. BT is a World Organization for Animal Health (OIE) listed multispecies disease and causes great socio-economic losses. To date, 28 serotypes of BTV have been reported worldwide and 23 serotypes have been reported from India. Transplacental transmission (TPT) and fetal abnormalities in ruminants had been reported with cell culture adopted live-attenuated vaccine strains of BTV. However, emergence of BTV-8 in Europe during 2006, confirmed TPT of wild-type/field strains of BTV. Diagnosis of BT is more important for control of disease and to ensure BTV-free trade of animals and their products. Reverse transcription polymerase chain reaction, agar gel immunodiffusion assay and competitive enzyme-linked immunosorbent assay are found to be sensitive and OIE recommended tests for diagnosis of BTV for international trade. Control measures include mass vaccination (most effective method), serological and entomological surveillance, forming restriction zones and sentinel programs. Major hindrances with control of BT in India are the presence of multiple BTV serotypes, high density of ruminant and vector populations. A pentavalent inactivated, adjuvanted vaccine is administered currently in India to control BT. Recombinant vaccines with DIVA strategies are urgently needed to combat this disease. This review is the first to summarise the seroprevalence of BTV in India for 40 years, economic impact and pathobiology.

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Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%