Role of tumor‑associated neutrophils in lung cancer (Review)

Abstract

Lung cancer is the most common malignancy and the leading cause of cancer mortality worldwide; therefore, it is very important to understand the mechanism of its occurrence and progression. It has reported that inflammation is linked to the incidence of various malignancies. Neutrophils not only participate in the inflammatory response, but are also involved in the composition of the tumor microenvironment. Tumor-associated neutrophils (TANs) are infiltrating neutrophils in tumors that directly promote tumor development and progression. Moreover, they regulate the immune microenvironment and affect the therapeutic efficacy and prognosis of lung cancer. In the present review, the role of TANs in lung cancer development/progression and the underlying molecular signaling are evaluated, as well as the possibility of TANs as a potential therapeutic target for lung cancer intervention. Contents 1. Introduction 2. TANs 3. TAN phenotype 4. Neutrophilic extracellular traps (NETS) 5. Mechanism of neutrophil recruitment 6. Regulatory mechanism of TANs on tumor angiogenesis/epithelial-mesenchymal transition (EMT) 7. TAN regulation of T cells 8. Additional mechanisms of neutrophils for facilitating lung cancer progression 9. TAN inhibition of lung cancer 10. TANs and the prognosis of lung cancer 11. Limitations of TAN research and TANs as a potential therapeutic target in lung cancer 12. Conclusions

Construction of a Lung Adenocarcinoma Prognostic Model Utilizing Serine and Glycine Metabolism-Related Genes

“…46 These cells are associated with poor prognosis in breast cancer, 47 colorectal cancer, 48 gastric cancer, 49 and lung cancer. 50,51 Our study supported these conclusions. In addition, the HR group was found to have elevated levels of APC coinhibition and MHC-I, while the LR group had a better HLA and type II IFN immune status.…”

“…In the tumor stroma of different human cancer types, increased mast cell density is linked with either good or poor prognosis, depending on the tumor type and stage. , In most tumors, neutrophils are linked with chronic inflammation and are favorable for the growth and development of invasive phenotypes of tumors . These cells are associated with poor prognosis in breast cancer, colorectal cancer, gastric cancer, and lung cancer. , Our study supported these conclusions. In addition, the HR group was found to have elevated levels of APC coinhibition and MHC-I, while the LR group had a better HLA and type II IFN immune status.…”

Predictive value of PD-L1 and TMB for short-term efficacy prognosis in non-small cell lung cancer and construction of prediction models

“…Most studies have investigated the relationship between neutrophils and the long-term prognosis of ICIs treatment, very few studies have investigated their relationship with the short-term efficacy of ICIs has. Moreover, studies ( 46 ) have shown that neutrophils can stimulate T cell response and increase anti-tumor response in the early stage of immunotherapy. In addition, there exists a heterogeneity of neutrophils and complex responses in the tumor immune microenvironment.…”

Neutrophils recruited by NKX2-1 suppression via activation of CXCLs/CXCR2 axis promote lung adenocarcinoma progression

“…Chemokines secreted by both tumor cells and TME play a central role in regulating the recruitment of immune cells such as neutrophils [31]. Notably, the in ltration of tumor-promoting neutrophils leads to increased tumor progression [31] and is normally associated with high-grade aggressive tumors [32].…”