Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling

Tan, Quanhui; Ma, Siyuan; Hu, Jianjun; Chen, Xiaohua; Yu, Yongsheng; Zang, Guoqing; Tang, Zhenghao

doi:10.1016/j.biopha.2016.11.004

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…More importantly, our KEGG analysis results show that 3.4.14.10 tripeptidyl peptidase II (TPPII) is significantly enriched in the intestine of plateau zokors. TPPII has demonstrated independent enzymatic activity involved in a wide range of activities, including antigen processing, apoptosis, DNA damage repair and cell division (Rockel et al, 2012;Tan et al, 2016). Studies have shown that in several malignant cell lines, TPPII translocates into the nucleus after γ-irradiation and ROS production and is involved in DNA repair (Preta et al, 2009(Preta et al, , 2010.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment

Wang²,

Liu³

et al. 2023

Front. Microbiol.

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Gut microbiota not only helps the hosts to perform many key physiological functions such as food digestion, energy harvesting and immune regulation, but also influences host ecology and facilitates adaptation of the host to extreme environments. Plateau zokors epitomize successful physiological adaptation to their living environment in the face of the harsh environment characterized by low temperature, low pressure and hypoxia in the Tibetan plateau region and high concentrations of CO2 in their burrows. Therefore, here we used a metagenomic sequencing approach to explore how gut microbiota contributed to the adaptive evolution of the plateau zokor on the Qinghai-Tibet Plateau. Our metagenomic results show that the gut microbiota of plateau zokors on the Tibetan plateau is not only enriched in a large number of species related to energy metabolism and production of short-chain fatty acids (SCFAs), but also significantly enriched the KO terms that involve carbohydrate uptake pathways, which well address energy uptake in plateau zokors while also reducing inflammatory responses due to low pressure, hypoxia and high CO2 concentrations. There was also a significant enrichment of tripeptidyl-peptidase II (TPPII) associated with antigen processing, apoptosis, DNA damage repair and cell division, which may facilitate the immune response and tissue damage repair in plateau zokors under extreme conditions. These results suggest that these gut microbiota and their metabolites together contribute to the physiological adaptation of plateau zokors, providing new insights into the contribution of the microbiome to the evolution of mammalian adaptation.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment

Wang²,

Liu³

et al. 2023

Front. Microbiol.

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“…Aminopeptidases are an important class of biomolecules that cleave peptide bonds at the N-terminal end of a protein or peptide. They are involved in many physiological and pathological processes, like angiogenesis, liver fibrosis, cancer development, diabetes mellitus, and immune response . Therefore, several aminopeptidases are potent therapeutic targets used for screening of drugs.…”

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confidence: 99%

“…To demonstrate this approach, we choose to work with dipeptidyl peptidase-4 (DPP-4, CD26), which is a major target for the treatment of T2DM. − It also plays an important role in many other biological processes such as T-cell activation, apoptosis, and cancer metastasis. Therefore, currently many pharmaceutical companies and research institutes are focusing on developing inhibitors of DPP-4. , The most widely used method for DPP-4 quantification is based on in vitro fluorescent enzymatic assays. − However, this assay is limited to ex vivo applications, as well as time-consuming and tedious, making the drug discovery process complex and inefficient.…”

mentioning

confidence: 99%

“…They are involved in many physiological and pathological processes, like angiogenesis, 1 liver fibrosis, 2 cancer development, 3 diabetes mellitus, 4 and immune response. 5 Therefore, several aminopeptidases are potent therapeutic targets used for screening of drugs. One such example is dipeptidyl peptidase-4 (DPP-4, CD26), a major target for the treatment of Type 2 diabetes mellitus (T2DM).…”

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confidence: 99%

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A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

et al. 2018

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Aminopeptidases, such as dipeptidyl peptidase-4 (DPP-4, CD26), are potent therapeutic targets for pharmacological interventions because they play key roles in many important pathological pathways. To analyze aminopeptidase activity in vitro (including high-throughput screening [HTS]), in vivo, and ex vivo, we developed a highly sensitive and quantitative bioluminescence-based readout method. We successfully applied this method to screening drugs with potential DPP-4 inhibitory activity. Using this method, we found that cancer drug mitoxantrone possesses significant DPP-4 inhibitory activity both in vitro and in vivo. The pharmacophore of mitoxantrone was further investigated by testing a variety of its structural analogues.

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Bioorthogonal chemistry in bioluminescence imaging

Godinat

Bazhin

Goun

2018

Drug Discovery Today

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Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling

Cited by 4 publications

References 43 publications

Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment

Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

Bioorthogonal chemistry in bioluminescence imaging

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