Role of trimetazidine in carbon tetrachloride induced liver damage in rats

Mate, Vijay Haribhau; Pandit, Vijaya; Wani, Dileep; Dhande, Priti

doi:10.5455/2319-2003.ijbcp20140221

Cited by 1 publication

(4 citation statements)

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“…22 However, the prevalence of hepatic disorders hinders the successful use of DOX and limits the oncologists from achieving the maximum benefit of this 3,7,23 The injury to liver is especially pertinent keeping in view the liver's key role in metabolism of DOX and is reported to occur even in the therapeutic doses. 5,12 This study was designed with an aim of comparing the hepatoprotection by trimetazidine (TMZ) and lovastatin, both commonly known for their cardioprotective benefits, in two different pre-treatment schedules. The drugs were also administered alone in two groups to establish that they themselves did not affect the liver enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…Definitive improvement was exhibited at the dose of 10 mg/kg. 12 So several times and doses of administration for TMZ have been proposed in the literature. Boussaid et al, in their study on hepatic ischemic reperfusion injury have proposed 10 mg/ kg per day for at least 7 consecutive days to be the optimum TMZ dosage for most effective protection at cellular and mitochondrial level.…”

Section: Discussionmentioning

confidence: 99%

“…The membrane damage is also protected by decreased intracellular acidosis and inhibited production of free radicals. 12 In groups 6 and 8, lovastatin was administered in a dose of 10 mg/kg/d orally for five and ten consecutive days respectively. In group 6, the three days pre-treatment conferred significant hepatoprotection as is evident by significant decrease in both the biochemical markers i.e.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Widely known for cardio protection, it is also being studied for its hepatoprotective benefits against various chemotherapeutic drugs including DOX. 2,12,13 Its hepatoprotective benefits in different doses and schedules for diverse causes of hepatic injuries have been studied. 13,14 This study was especially formulated to reach at an optimal pre-treatment dose and duration for TMZ to counter oxidative stress due to DOX.…”

mentioning

confidence: 99%

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Evaluation and comparison of the hepatoprotective effects of trimetazidine and lovastatin against doxorubicin-induced hepatotoxicity

Sikandar¹,

Farhat²,

Hamza³

2019

Int J Basic Clin Pharmacol

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Background: The dosage of highly efficacious anti-cancer drug doxorubicin (DOX) is often constrained as limited data exists on its hepatotoxic potential. The present study not only evaluated the extent of its hepatotoxicity but also aimed at curtailing it, by administration of two drugs i.e. trimetazidine and lovastatin, both of which are otherwise known for their cardioprotective benefits.Methods: The study was a lab-based randomized controlled study on mice. Acute toxicity was introduced with DOX injected intraperitoneally at a dose of 10 mg/kg and it was protected by oral administration of trimetazidine and lovastatin, both in a dose of 10 mg/kg. The protective drugs were both given for five and ten consecutive days in short and long term study designs whereby DOX was administered on the third and eighth days of the respective studies.Results: Doxorubicin administration caused significant hepatotoxicity reflected by markedly raised biomarkers (serum alanine aminotransferase and aspartate aminotransferase) and mild inflammation of liver parenchyma with a score of 4 as per Ishak grading scale. The changes were significantly attenuated by both the protective drugs in the ten days study design. However, in the five days study, lovastatin exhibited more significant hepatoprotection than trimetazidine.Conclusions: Pretreatment with two commonly available, cost effective and safe drugs can effectively prevent a potentially life-threatening adverse effect of DOX. This approach might prove very convenient for the health care providers as well as for the patients without burdening the economics.

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