Role of transrectal ultrasound elastography in the diagnosis of prostate carcinoma

Kanagaraju, Vikrant; Ashlyin, P V K; Elango, N. M.; Devanand, B

doi:10.4103/jmu.jmu_108_19

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…Benign lesions had lower elastography scores, whereas malignant lesions had higher scores. These findings align with those of Kanagaraju et al 18 , who reported similar results in their study. This correlation can be attributed to the fact that malignant lesions are characterized by replacing glandular tissue with malignant cells, resulting in a higher stiffness than benign lesions.…”

Section: Discussionsupporting

confidence: 93%

Advanced strain elastography is a reliable approach for prostate cancer detection in patients with elevated PSA levels

Almalki,

Mansour,

Ali

et al. 2024

Sci Rep

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This study aimed to examine the validity and reproducibility of strain elastography (SE) for detecting prostate cancer (PCa) in patients with elevated prostate-specific antigen (PSA) levels. The study included 107 patients with elevated PSA levels. All eligible patients underwent transrectal ultrasound (TRUS) with real-time elastography (RTE) to detect suspicious lesions. Two readers independently evaluated the lesions and assigned a strain ratio and elastography score to each lesion. Histopathology was used as a reference standard to estimate the validity of RTE in predicting malignant lesions. An intraclass correlation (ICC) was performed to detect reliability of the strain ratios and elastography scores. TRUS-guided biopsy detected malignancies in 64 (59.8%) patients. TRUS with RTE revealed 122 lesions. The strain ratio index (SRI) cut-off values to diagnose malignancy were 4.05 and 4.35, with sensitivity, specificity, and accuracy of 94.7%, 91.3%, and 93.4%, respectively. An elastography score > 3 was the best cut-off value for detecting malignancy. According to readers, the sensitivity, specificity, and accuracy were 91.3–94.7%, 89.5–93.4%, and 91.3–90.9%, respectively. Excellent inter-reader agreement was recorded for SRI and elastography scores, with ICC of 0.937 and 0.800, respectively. SE proves to be an efficient tool for detecting PCa with high accuracy in patients with elevated PSA levels.

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Section: Discussionsupporting

confidence: 93%

Advanced strain elastography is a reliable approach for prostate cancer detection in patients with elevated PSA levels

Almalki,

Mansour,

Ali

et al. 2024

Sci Rep

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“…Final reports were issued after reaching an agreement. 15,16 Radical surgery and follow-up for PCa: The patients received general anesthesia. Dissociation was performed in the retrorectal space to expose the prostate apex, prevesical space, and etropubic space.…”

Section: Methodsmentioning

confidence: 99%

Predicting Model of Biochemical Recurrence of Prostate Carcinoma (PCa-BCR) Using MR Perfusion-Weighted Imaging-Based Radiomics

Lin

et al. 2023

Technol Cancer Res Treat

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Objective To build a combined model that integrates clinical data, contrast-enhanced ultrasound, and magnetic resonance perfusion-weighted imaging-based radiomics for predicting the possibility of biochemical recurrence of prostate carcinoma and develop a nomogram tool. Method We retrospectively analyzed the clinical, ultrasound, and magnetic resonance imaging data of 206 patients pathologically confirmed with prostate carcinoma and receiving radical prostatectomy at Xiangyang No. 1 People’s Hospital from February 2015 to August 2021. Based on one to 7 years of follow-up (prostate specific antigen [PSA] level≥0.2 ng/mL, indicative of prostate carcinoma–biochemical recurrence), the patients were divided into biochemical recurrence group (n = 77) and normal group (n = 129). The training and testing sets were formed by dividing the patients at a 7:3 ratio. In training set, The magnetic resonance perfusion-weighted imaging–based radiomics radscore was generated using lasso regression. Several predictive models were built based on the patients’ clinical imaging data. The predictive efficacy (area under the curve) of these models was compared using the MedCalc software. The decision curve analysis was conducted using the R to compare the net benefit. Finally, an external validation was carried out on the testing set, and the nomogram tool was developed for predicting prostate carcinoma–biochemical recurrence. Result The univariate analysis confirmed that Tumor diameter, tumor node metastasis classification stage of tumor, lymph node metastasis or distance metastasis, Gleason grade, preoperative PSA, ultrasound (peak intensity, arrival time, and elastography grade), and magnetic resonance imaging-radscore1/2 were predictors of prostate carcinoma–biochemical recurrence. On the training set, the combined model based on the above factors had the highest predictive efficacy for prostate carcinoma–biochemical recurrence (area under the curve: 0.91; odds ratio 0.02, 95% confidence interval: 0.85-0.95). The predictive performance of the combined model was significantly higher than that of the model based on general clinical data (area under the curve: 0.74; odds ratio 0.04, 95% confidence interval: 0.67-0.81, P < .05), contrast-enhanced ultrasound (area under the curve: 0.61; odds ratio 0.05 95% confidence interval: 0.53-0.69, P < .05), and the magnetic resonance imaging–based radiomics model (area under the curve: 0.85; odds ratio 0.03, 95% confidence interval: 0.78-0.91, P = .01). The decision curve analysis also indicated the maximum net benefit derived from the combined model, which agreed with the validation results on the testing set. The nomogram tool developed based on the combined model achieved a good performance in clinical applications. Conclusion The magnetic resonance imaging texture parameters extracted by magnetic resonance perfusion-weighted imaging Lasso regression could help increase the accuracy of the predictive model. The combined model and the nomogram tool provide support for the clinical screening of the populations at a risk for biochemical recurrence.

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“…The important aspect from human literature to be considered to implement sonoelastography in canine prostate evaluation is that both SE and 2D‐SWE have been proven to be highly sensitive not only to distinguish the healthy from diseased parenchyma but also to guide tissues biopsies, thus reducing the need for a systematic prostate sample and improve the accuracy of diagnosis, distinguish the lesions to be sampled with suspicion of malignancy from more benign lesions (Anbarasan et al, 2021; Kanagaraju et al, 2020; Secasan et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Canine prostatic serum esterase and strain and 2D‐shear wave sonoelastography for evaluation of normal prostate in dogs: Preliminary results

Bucci

Signore

Vignoli

et al. 2023

Reprod Domestic Animals

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Canine prostatic serum esterase (CPSE) is considered a useful tool to identify prostate disorders in dogs, with increasing interest in ultrasound (US)‐based sonoelastography to non‐invasively detect prostate disorders. Since no report is available about a possible correlation between these diagnostic tools, we aimed to investigate a possible correlation between strain elastography (SE) and 2D‐shear wave elastography (SWE) and CPSE. Twenty‐one dogs were included and, on each animal, CPSE was evaluated followed by a complete US examination and SE and 2D‐SWE application. Healthy dogs were identified based on the CPSE results. All the dogs included were characterized by normal CPSE values (<52.3 ng/mL) and normal US prostate appearance. The prostate was characterized by intermediate stiffness with SE (pattern III – 84.7% for the left lobe and 79.27% for the right lobe) and softer than the abdominal wall (SR 0.6 for the left lobe and 0.56 for the right lobe), with low values for both m/s and kilopascals (kPa) for 2D‐SWE, pointing that the healthy tissue is not hard. 2D‐SWE results were, respectively, 13.51 ± 5.55 kPa and 2.31 ± 0.42 m/s for the left lobe and 18.05 ± 6.47 kPa and 2.39 ± 0.43 m/s for the right lobe. The significant difference between the right and left measurements expressed with kPa, not evidenced with m/s, can be considered indicative of m/s as the most reliable measurement to be considered regarding the prostate parenchyma. Even though no linear correlation was detected between CPSE and elastography values, these preliminary results evidence that the healthy prostates were characterized by a similar elastographic pattern, thus pointing that these techniques can be potentially useful to be applied in case of prostatic disorders to improve the accuracy of the final diagnosis in a non‐invasive way.

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Role of transrectal ultrasound elastography in the diagnosis of prostate carcinoma

Cited by 12 publications

References 31 publications

Advanced strain elastography is a reliable approach for prostate cancer detection in patients with elevated PSA levels

Advanced strain elastography is a reliable approach for prostate cancer detection in patients with elevated PSA levels

Predicting Model of Biochemical Recurrence of Prostate Carcinoma (PCa-BCR) Using MR Perfusion-Weighted Imaging-Based Radiomics

Canine prostatic serum esterase and strain and 2D‐shear wave sonoelastography for evaluation of normal prostate in dogs: Preliminary results

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