Role of Transplantation in the Treatment of Benign Solid Tumors of the Liver

Alagusundaramoorthy, Sayee Sundar; Vilchez, Valery; Zanni, Anthony; Sourianarayanane, Achuthan; Maynard, Erin; Shah, Malay B.; Daily, Michael F.; Peña, Luis; Gedaly, Roberto

doi:10.1001/jamasurg.2014.3166

Cited by 26 publications

(16 citation statements)

References 19 publications

(18 reference statements)

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“…1). In general, the surgical armamentarium consists of liver resection -including hypertrophy concepts like preoperative portal vein embolization, enucleation, hepatic artery ligation, and liver transplantation [27][28][29][30][31][32]. The choice of the procedure depends on HH size, number, and location, the surgeon's experience, and the institutional resources.…”

Section: Surgerymentioning

confidence: 99%

“…Published studies are mainly limited to small case series. However, Sundar Alagusundaramoorthy et al [30] analyzed the results of liver transplantations for benign solid tumors of the United Network of Organ Sharing. Of 87,280 transplantations, 25 have been performed for HH, and their overall survival rates were 87.8, 81.5, and 74.8% at 1-, 3-, and 5-year follow-ups, respectively.…”

Section: Surgerymentioning

confidence: 99%

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Benign Liver Tumors

et al. 2020

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Background: Due to the frequent use of medical imaging including ultrasonography, the incidence of benign liver tumors has increased. There is a large variety of different solid benign liver tumors, of which hemangioma, focal nodular hyperplasia (FNH), and hepatocellular adenoma (HCA) are the most frequent. Advanced imaging techniques allow precise diagnosis in most of the patients, which reduces the need for biopsies only to limited cases. Patients with benign liver tumors are mostly asymptomatic and do not need any kind of treatment. Symptoms can be abdominal pain and pressure effects on adjacent structures. The 2 most serious complications are bleeding and malignant transformation. Summary: This review focuses on hepatic hemangioma (HH), FNH, and HCA, and provides an overview on clinical presentations, surgical and interventional treatment, as well as conservative management. Treatment options for HHs, if indicated, include liver resection, radiofrequency ablation, and transarterial catheter embolization, and should be carefully weighed against possible complications. FNH is the most frequent benign liver tumor without any risk of malignant transformation, and treatment should only be restricted to symptomatic patients. HCA is associated with the use of oral contraceptives or other steroid medications. Unlike other benign liver tumors, HCA may be complicated by malignant transformation. HCAs have been divided into 6 subtypes based on molecular and pathological features with different risk of complication. Key Message: The vast majority of benign liver tumors remain asymptomatic, do not increase in size, and rarely need treatment. Biopsies are usually not needed as accurate diagnosis can be obtained using modern imaging techniques.

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Section: Surgerymentioning

confidence: 99%

Section: Surgerymentioning

confidence: 99%

Benign Liver Tumors

et al. 2020

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“…The risk for complications for patients with multiple HCAs is primarily driven by the size of the largest nodule, so management of these patients is driven by the size of the largest tumor. HCA is a rare indication for liver transplantation, but this can be considered in cases of HCA who are at increased risk for malignant transformation (e.g., β‐catenin activation or glycogen storage disease) who are not amenable to surgical resection (e.g., multiple HCA lesions) 11 …”

Section: Casementioning

confidence: 99%

“…HCA is a rare indication for liver transplantation, but this can be considered in cases of HCA who are at increased risk for malignant transformation (e.g., β-catenin activation or glycogen storage disease) who are not amenable to surgical resection (e.g., multiple HCA lesions). 11 Given the hormone-responsive nature of HCA, pregnancy can induce significant growth of HCA. However, pregnancy does not need to be discouraged, particularly for women with HCAs smaller than 5 cm, and an individualized approach using shared decision making is recommended.…”

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confidence: 99%

Evaluation and Management of Hepatocellular Adenomas

Mittal

Gopal

Khatri

et al. 2021

Clinical Liver Disease

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“…Считают, что 15-20% потенциальных реципиентов донорской печени погибают в ожидании операции. Боле того, пациенты с таким диагнозом, как амилоидоз, крупные нерезек табельные гемангиомы и кисты печени, в отсутствие подходящих прижизненных доноров могут находиться в листе ожидания неограниченно долгое время, поскольку показатель MELD, на котором основывается положение пациента в листе ожидания, длительное время остается низким [2][3][4][5][6].…”

Section: вве де ниеunclassified

Full-split liver transplantation. The first experience in Russian Federation

Восканян¹,

Колышев²,

Шабалин³

et al. 2021

Ann. hir. gepatol.

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Aim. To present the first successful full-split liver transplantation for two adults recipients in Russia.Materials and methods. The first successful full-split liver transplantation for two adults in ex situ way in Russia was made on 26th of September 2014 in the Burnasyan Federal Medical Biophysical Center of FMBA. The deceased donor was inside UNOS, Lee. The GRWR index in both recipients was near 1. The first recipient had been in a waiting list for 1 year, the second for 4 months. Both recipients had got liver cirrhosis in terminal stage.Results. The surgical procedure length was 650 and 660 min. The overall time of cold ischemia was 510 min. We observed a primary function of each graft. ISGLS B and Clavien-Dindo 3A biliary leak complications were observed in both recipients. Both patients were discharged after 33 and 34 days. Overall survival for this moment is 68 months.Conclusion. Full-split liver transplantation for two adults in ex situ way seems to be a complicated procedure both from the technical and organizing points of view. It demanding good mastership and coordination between surgical team members. At the same time, that treatment method has to be spread widely to improve treatment of patients with end-stage cirrhosis results.

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Role of Transplantation in the Treatment of Benign Solid Tumors of the Liver

Cited by 26 publications

References 19 publications

Benign Liver Tumors

Benign Liver Tumors

Evaluation and Management of Hepatocellular Adenomas

Full-split liver transplantation. The first experience in Russian Federation

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