Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice

Li, Jinquan; Chen, Yu‐Shan; Chen, Qiao Yi; Liú, Dan; Xu, Li‐Yan; Cheng, Guirong; Yang, Xu; Guo, Zhenzhong; Zeng, Yan

doi:10.1016/j.envpol.2019.01.091

Cited by 25 publications

(11 citation statements)

References 46 publications

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“…C‐fiber afferents bearing TRPV1 and TRPA1 are implicated in promoting the physiologic features of asthma and experimental models of allergic airway inflammation. C‐fiber neuronal innervation is much denser in asthmatic patients and these neurons exhibit hyperexcitability 26,27 . Further, neuronal TRPV1 expression can be increased following exposure to ozone in the ovalbumin (OVA)‐induced murine asthma model 27 and TRPV1+ c‐fiber ablation alleviates house dust mite (HDM)‐induced lung inflammation 28 .…”

Section: Airway Nociceptors Contribute To Allergic Inflammation and Airway Constrictionmentioning

confidence: 99%

“…C‐fiber neuronal innervation is much denser in asthmatic patients and these neurons exhibit hyperexcitability 26,27 . Further, neuronal TRPV1 expression can be increased following exposure to ozone in the ovalbumin (OVA)‐induced murine asthma model 27 and TRPV1+ c‐fiber ablation alleviates house dust mite (HDM)‐induced lung inflammation 28 . Genetic deficiency or antagonism of TRPA1 can prevent immune cell infiltration and airway hypercontraction 29 .…”

Section: Airway Nociceptors Contribute To Allergic Inflammation and Airway Constrictionmentioning

confidence: 99%

“…In contrast, OVA‐induced allergic inflammation combined with ozone exposure exacerbated airway hypersensitivity and inflammation, which was associated with elevated CGRP levels 27 . Critically, this synergistic activity between OVA and ozone was reversed when TRPV1 neurons were inhibited with capsazepine, which was associated with reduced CGRP and TSLP content in lung tissue 27 .…”

Section: Neuropeptides As Immunoregulatorsmentioning

confidence: 99%

“…C-fiber neuronal innervation is much denser in asthmatic patients and these neurons exhibit hyperexcitability. 26,27 Further, neuronal TRPV1 expression can be increased following exposure to ozone in the ovalbumin (OVA)-induced murine asthma model 27 and TRPV1+ c-fiber ablation alleviates house dust mite (HDM)-induced lung inflammation. 28 29 It should be noted that these nociceptor populations express various receptors for innate immune cell mediators like histamine and cysteinyl leukotriene (cys-LT) and treatment with these molecules can also sensitize neurons 30,31 and promote enhanced neuropeptide release (Fig.…”

Section: Airway Nociceptors Contribute To Allergic Inflammation and A...mentioning

confidence: 99%

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Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease

Jean

Good

Inclan-Rico

et al. 2021

Journal of Leukocyte Biology

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Communication between the nervous and immune systems serves a key role in host‐protective immunity at mucosal barrier sites including the respiratory tract. In these tissues, neuroimmune interactions operate in bidirectional circuits that can sense and respond to mechanical, chemical, and biologic stimuli. Allergen‐ or helminth‐induced products can produce airway inflammation by direct action on nociceptive afferents and adjacent tissues. The activity of nociceptive afferents can regulate innate and adaptive immune responses via neuropeptides and neurotransmitter signaling. This review will summarize recent work investigating the role of neuropeptides CGRP, VIP, neuromedins, substance P, and neurotransmitters dopamine and the B2‐adrenoceptor agonists epinepherine/norepinepherine, each of which influence type 2 immunity by instructing mast cell, innate lymphoid cell type 2, dendritic cell, and T cell responses, both in the airway and the draining lymph node. Afferents in the airway also contain receptors for alarmins and cytokines, allowing their activity to be modulated by immune cell secreted products, particularly those secreted by mast cells. Taken together, we propose that further investigation of how immunoregulatory neuropeptides shape respiratory inflammation in experimental systems may reveal novel therapeutic targets for addressing the increasing prevalence of chronic airway disease in humans.

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Section: Airway Nociceptors Contribute To Allergic Inflammation and Airway Constrictionmentioning

confidence: 99%

Section: Airway Nociceptors Contribute To Allergic Inflammation and Airway Constrictionmentioning

confidence: 99%

Section: Neuropeptides As Immunoregulatorsmentioning

confidence: 99%

Section: Airway Nociceptors Contribute To Allergic Inflammation and A...mentioning

confidence: 99%

See 2 more Smart Citations

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease

Jean

Good

Inclan-Rico

et al. 2021

Journal of Leukocyte Biology

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“…A similar study showed that a pollutant known as trimellitic anhydride can increase TRPV1 expression as well as amplify the levels of IL-13, SP, prostaglandin D2, and nerve growth factor in the lungs of OVA asthmatic mice ( 141 ). In the same experimental model, Li et al identified ozone as an environmental pollutant with similar effects on TRPV1 and the inflammation pattern in asthma as the allergens mentioned above ( 142 ). Small particulate matter can also inflict bronchial mucosal damage and thickening of bronchial smooth muscles in asthmatic mice ( 143 ).…”

Section: Capsaicin In Asthmamentioning

confidence: 97%

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

et al. 2021

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Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects.

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Short-Term Health Effects of Air Pollution

Izah,

Ogwu,

Etim

et al. 2024

The Handbook of Environmental Chemistry

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Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice

Cited by 25 publications

References 46 publications

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease

Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review)

Short-Term Health Effects of Air Pollution

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