Role of Toll-like receptors in cervical, endometrial and ovarian cancers: A review

Husseinzadeh, Nader; Davenport, Sara

doi:10.1016/j.ygyno.2014.08.013

Cited by 45 publications

(40 citation statements)

References 38 publications

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“…gynecologic cancers. 34 Interestingly, we also found an important gene of DPT, whose downregulation is reportedly related to UL. 14 Herein, DPT was also decreased (FDR = 5.62E-13).…”

Section: Identification Of Differentially Expressed Genessupporting

confidence: 51%

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Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas

Xia

Liu

et al. 2016

J of Obstet and Gynaecol

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“…gynecologic cancers. 34 Interestingly, we also found an important gene of DPT, whose downregulation is reportedly related to UL. 14 Herein, DPT was also decreased (FDR = 5.62E-13).…”

Section: Identification Of Differentially Expressed Genessupporting

confidence: 51%

“…LGALS3 was related to endometrial carcinoma . TLR3 was a critical immunomodulator that played an important role in the development of gynecologic cancers . Interestingly, we also found an important gene of DPT, whose downregulation is reportedly related to UL .…”

Section: Resultsmentioning

confidence: 51%

Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas

Xia

Liu

et al. 2016

J of Obstet and Gynaecol

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“…Pathogens in the vagina can promote TLR and integrin protein expression in the cervix, thereby inducing the occurrence of cervical cancer, confirming that inflammation is an important trigger factor for cervical cancer [24]. In recent years, the role of TLRs in tumorigenesis has attracted more and more attention.…”

Section: Discussionmentioning

confidence: 99%

Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection

Rao

Jin

et al. 2017

BioMed Research International

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Human papillomavirus (HPV) can activate Toll-like receptor (TLR)/nitric oxide (NO) signaling pathways; however, whether the TLR/NO pathway is involved in cervical cancer caused by high-risk HPV (HR-HPV) remains unclear. In this study, 43 HR-HPV-positive patients with cervical cancer (CC group), 39 HR-HPV-positive patients with a healthy cervix (HR-HPV group), and 33 HR-HPV-negative controls were recruited. NO concentration in cervical canal and expression of inducible NO synthase (iNOS) in cervical tissues were detected. Expressions of key TLR/NO pathway genes (TLR3/4/7/8, NF-κB p65, and iNOS) in cervical epithelial cells were detected by quantitative reverse transcription PCR. Expressions of TLR4, NF-κB p65, and iNOS in CaSki, HeLa, and C33a cells were determined by Western blot. NO concentration in cervical canal of CC group was significantly higher than in other groups (P < 0.05). Positive rates of iNOS in cervical tissues were 72.1%, 28.2%, and 3.1% in the CC group, HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4, TLR7, TLR8, NF-κB p65, and iNOS in cervical epithelial cells were higher in CC group than in other groups (P < 0.05). Both mRNA and protein levels of TLR4, NF-κB p65, and iNOS were higher in HPV-positive HeLa and CaSki cells than in HPV-negative C33a cells (P < 0.05). Together, these results suggest that TLR/NO signaling pathway may be involved in pathogenesis of cervical cancer caused by HR-HPV.

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“…However, there are few reports on immune-related gene signature associated with cancer prognosis. and TLR5 were reported to be highly expressed in normal and neoplastic ovarian epithelium (36).…”

Section: Discussionmentioning

confidence: 99%

Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Ovarian Cancer

Wang

Bao

Nie

et al. 2020

Preprint

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Background: Ovarian cancer (OV) is the most common gynecological cancer and is a major cause of cancer-related death among women worldwide. Immunotherapy has recently been of great interest, and it has been proven to be an effective treatment strategy. For this reason, the work here attempts to produce a prognostic immune-related gene pair (IRGP) signature to estimate OV patient survival. Methods: The Gene ExpressionOmnibus (GEO) and the Cancer Genome Atlas (TCGA) databases provided the genetic expression profiles and clinical data of OV patients, whose samples were divided into training, validation, and testing sets. The InnateDB database and the least absolute shrinkage and selection operator (LASSO) regression model, were used to build an IRGP signature. The functional enrichment analysis was performed to investigate the biological activities of IRGPs. Then, the correlation between risk scores and clinicopathological parameters was further analyzed. Finally, we compared our signature and four existing signatures for OV. Results: We first identified a 17-IRGP signature significantly associated with survival based on LASSO regression model. The average area under the curve (AUC) values of the training, validation, and all

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Role of Toll-like receptors in cervical, endometrial and ovarian cancers: A review

Cited by 45 publications

References 38 publications

Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas

Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas

Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection

Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Ovarian Cancer

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