Role of titrated low dose oral misoprostol solution in induction of labour

Antil, Sarvottma; Gupta, Usha

doi:10.18203/2320-1770.ijrcog20160583

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…[6][7][8][9][10][11][12] Misoprostol has advantages of being easy to use, various routes administration like the vaginal, sublingual and oral and having a longer shelf life. 13 Misoprostol could be one of the best options for labour induction, as titrated low-dose oral solution seems to be the safest in terms of caesarean section risk, while vaginal misoprostol tablets are the most effective in achieving vaginal delivery within 24 hours of induction. 14 Since detailing the use of misoprostol for cervical ripening and labour induction, there has been growing interest in this agent.…”

Section: Introductionmentioning

confidence: 99%

Oral misoprostol solution in comparison to vaginal misoprostol for induction of labour in a randomized controlled trial

Abbas

Thabet

Gamrah

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: With more than 15% of all gravid women requiring prostaglandins in cervical ripening and labour induction. However, evidence is not clear about the preferred route or dose of the drug. So, this study was designed with objectives to compare the induction delivery interval and safety of titrated oral misoprostol solution with vaginal misoprostol for labour induction in term primigravida women.Methods: This randomized controlled clinical trial was conducted on a total of 100 patients randomly selected among primigravida at term women undergoing induction of labour for obstetric or medical indication for labour induction in Ain Shams University Maternity Hospital. They were divided into two Groups: Group I: patients undergoing induction of labour using misoprostol oral solution and Group II: patients undergoing induction of labour using vaginal misoprostol.Results: Oral misoprostol solution has less induction delivery duration and less side effects than vaginal misoprostol. The induction-delivery time with the oral route compared to the vaginal one (15.2 versus 20.3 hours respectively) with significant p-value (<0.001).Conclusions: Titrated oral misoprostol is safe and effective for labour induction in primigravida patients with unfavorable cervix.

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Section: Introductionmentioning

confidence: 99%

Oral misoprostol solution in comparison to vaginal misoprostol for induction of labour in a randomized controlled trial

Abbas

Thabet

Gamrah

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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“…Certain disadvantages are associated with oxytocin use like need to administer it by intravenous route, lack of stability at room temperature, shorter shelf life, and being relatively expensive. Misoprostol has advantages of being easy to use, convenient administration by various routes like the vaginal, sublingual and oral, being stable at room temperature, having a longer shelf life, and being relatively inexpensive [17].…”

Section: Introductionmentioning

confidence: 99%

Oral Misoprostol Solution for Induction of Labour

Deshmukh

Rajamanya

Yelikar

2016

J Obstet Gynecol India

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“…Antil has commented that low dose oral misoprostol solution in titrated doses can be used as a safe and effective alternative in induction of labour as it has lower uterine hyperactivity with good neonatal outcome. Oxytocin has its own disadvantages in terms of intravenous use, expensive, shorter shelf life, misoprostol takes the upper hand in these aspects and misoprostol is as effective as oxytocin for induction of labour [3] The BJOG review article suggests that titrated low dose oral misoprostol solution was identified to be the most cost effective method with a favourable safety profile [11] . Ashokan has used increment doses of misoprostol solution was used for induction of labour and compared with oxytocin infusion for induction of labour.…”

Section: Discussionmentioning

confidence: 99%

“…Tachysystole is the presence of at least 6 contractions in 10 minutes, over at least two 10 mins windows. Hyperstimulation was defined as tachysystole or hypertonus with non reassuring fetal heart rate patterns like late decelerations, prolonged decelerations, tachycardia or reduced fetal heart rate variability needing intervention [3] . Induction failure was defined as not entering into the active phase after 24 hours of misoprostol treatment.…”

Section: Methodsmentioning

confidence: 99%

“…Oxytocin use as an inducing agent has certain disadvantages like its intravenous route of administration, restricted ambulation of the patient, lack of stability at room temperature make its use cumbersome [2] . Prostaglandins are still the single most effective means and are widely recognized as standard methods of induction of labour [3] . Misoprostol (PGE1) is a synthetic analogue (15 deoxy 16 hydroxy 16 methyl PGE1) causes uterine contractions and ripening of the cervix.…”

Section: Introductionmentioning

confidence: 99%

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Simplifying induction of labour

Pujar¹,

As²,

Gl³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Labour induction is one of the most common procedure in obstetrics .Oxytocin is one of the time tested drug , but certain disadvantages associated with oxytocin can be countered by using misoprostol as labour inducing agent. Objectives: 1. To know the efficacy of oral Misoprostol solution in inducing labour 2. To calculate the induction delivery interval 3.To know the maternal and fetal outcome in the study population. Methodology: A prospective observational hospital based study involving 200 term pregnant patients getting admitted to the labour ward. All of them were induced with oral misoprostol in solution form at a static dose regimen, second hourly (20 ug) for a total of five doses. Labour monitored as per the labour room protocol, reassessed after five doses or earlier as per clinical progress. Results: 200 patients were included, the efficacy of its use was excellent, mean number of doses required was 5, with the average induction delivery interval of 13.65 hrs, with 77.5% of vaginal delivery rate and 22.5% of caesarean rate, 30% needed oxytocin augmentation and 6.5% of the babies had meconium staining of liquor, of them 23.08% showed signs of meconium aspiration syndrome and one perinatal death was noted in the study. Conclusion:Oral misoprostol solution in static dosage is a simple, safe and effective method for induction of labour at term.

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Role of titrated low dose oral misoprostol solution in induction of labour

Cited by 6 publications

References 9 publications

Oral misoprostol solution in comparison to vaginal misoprostol for induction of labour in a randomized controlled trial

Oral misoprostol solution in comparison to vaginal misoprostol for induction of labour in a randomized controlled trial

Oral Misoprostol Solution for Induction of Labour

Simplifying induction of labour

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