Role of titanium in bio implants and additive manufacturing: An overview

Grover, Tarun; Pandey, Anamika; Kumari, Soni; Awasthi, Ankita; Singh, Bharat; Dixit, Pradipkumar; Singhal, Piyush; Saxena, Kuldeep K.

doi:10.1016/j.matpr.2020.02.636

Cited by 58 publications

(29 citation statements)

References 42 publications

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“…The relation between the printing parameters and the resulting surface quality, especially for convoluted structures, is still under investigation [39,40]. So far, the powder bed fusion (PBF) techniques, Selective Laser Melting (SLM) and electron beam melting (EBM), are used the most for the fabrication of customized metal implants [41][42][43]. In recent years, many researchers have devoted their studies to 3D printing of Ti6Al4V titanium alloy for biomedical applications [44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

et al. 2020

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The 3D printing process offers several advantages to the medical industry by producing complex and bespoke devices that accurately reproduce customized patient geometries. Despite the recent developments that strongly enhanced the dominance of additive manufacturing (AM) techniques over conventional methods, processes need to be continually optimized and controlled to obtain implants that can fulfill all the requirements of the surgical procedure and the anatomical district of interest. The best outcomes of an implant derive from optimal compromise and balance between a good interaction with the surrounding tissue through cell attachment and reduced inflammatory response mainly caused by a weak interface with the native tissue or bacteria colonization of the implant surface. For these reasons, the chemical, morphological, and mechanical properties of a device need to be designed in order to assure the best performances considering the in vivo environment components. In particular, complex 3D geometries can be produced with high dimensional accuracy but inadequate surface properties due to the layer manufacturing process that always entails the use of post-processing techniques to improve the surface quality, increasing the lead times of the whole process despite the reduction of the supply chain. The goal of this work was to provide a comparison between Ti6Al4V samples fabricated by selective laser melting (SLM) and electron beam melting (EBM) with different building directions in relation to the building plate. The results highlighted the influence of the process technique on osteoblast attachment and mineralization compared with the building orientation that showed a limited effect in promoting a proper osseointegration over a long-term period.

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Section: Introductionmentioning

confidence: 99%

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

et al. 2020

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“…Electron beam melting (EBM) employs an electron beam in a high vacuum chamber at a very high temperature to melt the metal powder and fabricate metal parts layer-by-layer [ 26 , 43 , 44 ]. Typical materials used in the EBM process for surgery applications are commercially pure titanium (CP-Ti), titanium alloys, stainless steel, magnesium alloys, and nickel alloys [ 37 , 43 , 45 , 46 ].…”

Section: Additive Manufacturing Techniquesmentioning

confidence: 99%

Anatomical Engineering and 3D Printing for Surgery and Medical Devices: International Review and Future Exponential Innovations

Cornejo¹,

Cornejo-Aguilar

Vargas

et al. 2022

BioMed Research International

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Three-dimensional printing (3DP) has recently gained importance in the medical industry, especially in surgical specialties. It uses different techniques and materials based on patients’ needs, which allows bioprofessionals to design and develop unique pieces using medical imaging provided by computed tomography (CT) and magnetic resonance imaging (MRI). Therefore, the Department of Biology and Medicine and the Department of Physics and Engineering, at the Bioastronautics and Space Mechatronics Research Group, have managed and supervised an international cooperation study, in order to present a general review of the innovative surgical applications, focused on anatomical systems, such as the nervous and craniofacial system, cardiovascular system, digestive system, genitourinary system, and musculoskeletal system. Finally, the integration with augmented, mixed, virtual reality is analyzed to show the advantages of personalized treatments, taking into account the improvements for preoperative, intraoperative planning, and medical training. Also, this article explores the creation of devices and tools for space surgery to get better outcomes under changing gravity conditions.

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“…Titanium is widely used not only in surgical dentistry and maxillofacial surgery, but also in other areas of surgery and implantology [5][6][7]. A large number of works [8][9][10] are devoted to the study of titanium surface treatment methods.…”

Section: The Choice Of Materials Samples For the Experimentsmentioning

confidence: 99%

“…It is well known that titanium is useful as a substrate for cell culture. The biocompatibility of titanium implants has been tested on various cells, for example fibroblasts, osteoblasts, chondrocytes, and bone marrow stromal cells [7][8][9][10]. To improve the interaction of cells with titanium implants, their surface has been modified in various ways [11].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Various Variants of the Nanostructured Surface of Titanium with MSCs Isolated from Adipose Tissue

et al. 2021

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Titanium has been successfully used in dental implantology for a long time. Due to the osseointegration process, titanium implants are able to withstand the chewing load. This article is devoted to the study of surface treatment methods of titanium alloys and the study of their interaction with mesenchymal stem cells (MSCs). The surface microrelief can influence MSC differentiation in different ways, which subsequently gives it osteogenic potential. The paper proposes modes of surface modification of titanium alloys on Grade 4 and Grade 1 by chemical and electrochemical (anodizing) etching. The possibility of modifying the surface of titanium alloys using the synthesis of graphene layers has been proposed in this paper for the first time. The osteogenic potential of a particular surface was assessed by the number of mesenchymal stem cells cultured on them under identical conditions.

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Role of titanium in bio implants and additive manufacturing: An overview

Cited by 58 publications

References 42 publications

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

Anatomical Engineering and 3D Printing for Surgery and Medical Devices: International Review and Future Exponential Innovations

Interaction of Various Variants of the Nanostructured Surface of Titanium with MSCs Isolated from Adipose Tissue

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