Role of Tissue Liver X-Receptors Level in Skin Diseases

Bedewi, Ahmed El; Awad, Mohamed M.; Nada, Eman

doi:10.1007/s10989-013-9349-9

Cited by 2 publications

(2 citation statements)

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“…LXRs regulate different metabolic functions, such as cholesterol metabolism, − lipogenesis, , carbohydrate metabolism, and energy metabolism. Moreover, LXRs regulate inflammation and immune function in many cell types and have been identified as anti-inflammatory transcription factors. , LXRs are also involved in the regulation of cell growth, development, reproduction, and homeostasis. , Consequently, LXR ligands may have utility for the treatment of skin diseases, , rheumatoid arthritis, antithrombotic, Alzheimer’s disease (AD), ,, Parkinson’s disease (PD), dyslipidemia, atherosclerosis, − and multiple sclerosis (MS) …”

Section: Introductionmentioning

confidence: 99%

“…22,23 LXRs are also involved in the regulation of cell growth, development, reproduction, and homeostasis. 24,25 Consequently, LXR ligands may have utility for the treatment of skin diseases, 26,27 rheumatoid arthritis, 28 antithrombotic, 29 Alzheimer's disease (AD), 7,8,30 Parkinson's disease (PD), 31 dyslipidemia, 32 atherosclerosis, 33−36 and multiple sclerosis (MS). 37 In cancer biology, LXR ligands have shown antiproliferative effects on different cancer cell types; the activation of LXRs decreases proliferation by reducing the intracellular cholesterol level necessary for lymphocytes to synthesize its cellular membrane during proliferation, 38 and in glioblastomas, the activation of LXRs decreases cholesterol levels and hence promotes tumor cell death.…”

Section: ■ Introductionmentioning

confidence: 99%

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Recent Advances in the Medicinal Chemistry of Liver X Receptors

et al. 2018

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Nuclear hormone receptors represent a large family of ligand-activated transcription factors that include steroid receptors, thyroid/retinoid receptors, and orphan receptors. Among nuclear hormone receptors, the liver X receptors have emerged as very important drug targets. These receptors regulate some of the most important metabolic functions, and they were also identified as anti-inflammatory transcription factors and regulators of the immune system. The development of drugs targeting liver X receptors continues to be a challenge, but advances in our knowledge of receptor structure and function move us forward, toward achieving this goal. This review highlights the latest advances in the development of synthetic LXR modulators in the primary literature from 2013 to 2017. In this review, we place great emphasis on the structure and function of LXRs because of their essential role in the drug design process. The structure-activity relationships of the most active and promising synthetic modulators are discussed.

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