Role of tissue antioxidant defence in thyroid cancers

Sadani, Geeta R; Nadkarni, G.D.

doi:10.1016/s0304-3835(96)04484-9

Cited by 54 publications

(31 citation statements)

References 21 publications

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“…Results of the studies analyzing the indicators of SOD, GPx and catalase enzymes in thyroid tissue are quite contradictory [11,12,211,212]. The discrepancy may be due to variation in the samples analyzed, grade of hyperthyroidism, methods of determination and result expression (enzyme activity or concentration, expression of enzyme concentration or activity per protein or tissue mass).…”

Section: Antioxidant Statusmentioning

confidence: 99%

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

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Section: Antioxidant Statusmentioning

confidence: 99%

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

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“…Disruption of the equilibrium between the generation and removal of free radicals leads to oxidative stress and changes in the macromolecules, such as nucleic acid, lipids, and proteins (12). Currently, mounting evidence suggests that free radicals play a pivotal role in tissue transformation into malignancy (13,14).…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative damage to cells and tissues may be indicated by the serum level of MDA, marking lipid peroxidation (8). Evidently, free radicals are involved in the physiological and pathological processes in the thyroid gland (13,14). According to previous studies, thyroid cancer is associated with enhanced oxidative stress (15,16).…”

Section: Discussionmentioning

confidence: 99%

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

et al. 2018

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Background: Oxidative stress has been shown to be the most significant influential factor in cancer pathogenesis. Follicular cells are affected in papillary thyroid carcinoma (PTC), which is the most prevalent thyroid cancer associated with oxidative stress. As a noninvasive source of body metabolism, saliva has recently attracted the attention of researchers as an investigative specimen. The present study aimed to evaluate and compare the levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) in the blood and saliva samples of PTC patients and healthy control subjects. Methods: This case-control study was conducted on the patients with PTC referring to Taleghani Hospital in Tehran, Iran. Age-and gender-matched healthy volunteers were selected as the control group. Blood and saliva samples were obtained from all the subjects. Measurement of the MDA and TAC levels was performed using a commercial kit (ZellBio GmbH, Germany) based on colorimetric methods. Data analysis was performed in MedCalc software version 14.8.1.

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“…Total thyroid stimulating hormone (TSH) was assessed using EIA kit (BioCheck) as previously done (Fujita, 2002). Estrogen (estradiol, E2) was determined by using EIA kit as well (Sadani, 1996). Aspartate aminotransferase (AST) and alanine aminotransaminase (ALT) were determined by Reitman-Frankel colorimetric method by using a commercial kit (Crescent Diagnostics; cat.…”

Section: Serum Biochemistrymentioning

confidence: 99%

Comparison of DNA Damage and Homocysteine Content in Blood of Thyroid Carcinoma Patients and Control Subjects in Punjab, Pakistan

et al. 2018

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Background: Thyroid cancers are common endocrine tumors with diverse medical and histological structures. During development/progression from normal to neoplastic cell, there is a gradual increase in the function/activity of proto-oncogenes, transcription factors and metastasis elements. The main objective of this study is to evaluate per-oxidation of lipid content, total oxidative stress, and the profile of homocysteine (and DNA damage) in the erythrocytes of thyroid carcinoma patients as compared with those of control subjects. Methods: All risk variables and biochemical analyses were quantitatively determined using standard methods. Results: A noteworthy increase in malondialdehyde, globulin, and DNA damage in thyroid carcinoma patients were repeatedly observed. In contrast, healthy individuals showed an increased level of HDL-C and total anti-oxidant response. Conclusion: It is suggested that these parameters have a pivotal role in the diagnostic process of determining thyroid carcinoma patients. Oxidized products of macromolecules in the blood of such patients impart major function in causing thyroid carcinoma disease.

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Role of tissue antioxidant defence in thyroid cancers

Cited by 54 publications

References 21 publications

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

Comparison of DNA Damage and Homocysteine Content in Blood of Thyroid Carcinoma Patients and Control Subjects in Punjab, Pakistan

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