Role of tissue and circulating microRNAs and DNA as biomarkers in medullary thyroid cancer

Chiacchiarini, Martina; Trocchianesi, Sofia; Besharat, Zein Mersini; Pò, Agnese; Ferretti, Elisabetta

doi:10.1016/j.pharmthera.2020.107708

Cited by 8 publications

(4 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the increasing interest in circulating biomarkers offers a new perspective for earlier NENs diagnosis [ 59 ]. Furthermore, some studies have been conducted to emphasize the potential of miRNAs as biomarkers and for easier grade stratification and tissue discrimination in GEP-NENs [ 54 , 60 – 62 ] and as promising diagnostic and prognostic factors in MTC [ 63 – 65 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

et al. 2022

View full text Add to dashboard Cite

Background Neuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the ability to secrete peptide hormones and biogenic amines but other reliable biomarkers are lacking, making diagnosis and identification of the primary site very challenging. While in some NENs, such as the pancreatic ones, next generation sequencing technologies allowed the identification of new molecular hallmarks, our knowledge of the molecular profile of NENs from other anatomical sites is still poor. Methods Starting from the concept that NENs from different organs may be clinically and genetically correlated, we applied a multi-omics approach by combining multigene panel testing, CGH-array, transcriptome and miRNome profiling and computational analyses, with the aim to highlight common molecular and functional signatures of gastroenteropancreatic (GEP)-NENs and medullary thyroid carcinomas (MTCs) that could aid diagnosis, prognosis and therapy. Results By comparing genomic and transcriptional profiles, ATM-dependent signaling emerged among the most significant pathways at multiple levels, involving gene variations and miRNA-mediated regulation, thus representing a novel putative druggable pathway in these cancer types. Moreover, a set of circulating miRNAs was also selected as possible diagnostic/prognostic biomarkers useful for clinical management of NENs. Conclusions These findings depict a complex molecular and functional landscape of NENs, shedding light on novel therapeutic targets and disease biomarkers to be exploited.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Circulating mi-RNAs can be easily obtained from MTC patients, and their levels correlate with clinical-pathological features and disease prognosis [ 83 ]. Zhang et al analyzed the expression of serum mi-RNA in 15 patients with aggressive MTC.…”

Section: Liquid Biopsy In Medullary Thyroid Cancermentioning

confidence: 99%

Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer

Romano

Martorana

Pennisi

et al. 2021

IJMS

View full text Add to dashboard Cite

Thyroid cancer is the most common malignancy of the endocrine system, encompassing different entities with distinct histological features and clinical behavior. The diagnostic definition, therapeutic approach, and follow-up of thyroid cancers display some controversial aspects that represent unmet medical needs. Liquid biopsy is a non-invasive approach that detects and analyzes biological samples released from the tumor into the bloodstream. With the use of different technologies, tumor cells, free nucleic acids, and extracellular vesicles can be retrieved in the serum of cancer patients and valuable molecular information can be obtained. Recently, a growing body of evidence is accumulating concerning the use of liquid biopsy in thyroid cancer, as it can be exploited to define a patient’s diagnosis, estimate their prognosis, and monitor tumor recurrence or treatment response. Indeed, liquid biopsy can be a valuable tool to overcome the limits of conventional management of thyroid malignancies. In this review, we summarize currently available data about liquid biopsy in differentiated, poorly differentiated/anaplastic, and medullary thyroid cancer, focusing on circulating tumor cells, circulating free nucleic acids, and extracellular vesicles.

show abstract

“…Non-coding RNAs (ncRNAs), once regarded as “non-functional,” have now been established as both oncogenic drivers and tumor suppressors across various major cancer types, providing a novel direction for understanding the diverse phenotypic manifestations of cancer [ 9 – 12 ]. Circular RNAs (circRNAs), a distinct subtype of ncRNAs, are generated by alternative splicing and occurs widely found in cancers.…”

Section: Introductionmentioning

confidence: 99%

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer

Zhou,

Li,

Jiang

et al. 2024

Cancer Gene Ther

View full text Add to dashboard Cite

Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancers grow slowly, they can become refractory, leading to a high mortality rate once they exhibit recurrence, metastasis, resistance to radioiodine therapy, or a lack of differentiation. However, the mechanisms underlying these malignant characteristics remain unclear. Circular RNAs, a type of closed-loop non-coding RNAs, play multiple roles in cancer. Several studies have demonstrated that circular RNAs significantly influence the development of thyroid cancers. In this review, we summarize the circular RNAs identified in thyroid cancers over the past decade according to the hallmarks of cancer. We found that eight of the 14 hallmarks of thyroid cancers are regulated by circular RNAs, whereas the other six have not been reported to be correlated with circular RNAs. This review is expected to help us better understand the roles of circular RNAs in thyroid cancers and accelerate research on the mechanisms and cure strategies for thyroid cancers.

show abstract

Role of tissue and circulating microRNAs and DNA as biomarkers in medullary thyroid cancer

Cited by 8 publications

References 138 publications

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer

Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer

Contact Info

Product

Resources

About